Basic Information

Gene Symbol
RREB1
Assembly
GCA_036937285.1
Location
JAUPFZ010000024.1:7267523-7288014[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.85 1.2e+02 4.7 0.3 1 23 93 116 93 116 0.92
2 12 0.61 87 5.2 0.3 1 13 151 163 151 172 0.77
3 12 0.02 2.8 9.9 0.1 1 23 299 321 299 321 0.97
4 12 0.0011 0.15 13.9 0.4 1 23 330 352 330 352 0.99
5 12 0.00066 0.095 14.5 2.0 1 23 358 381 358 381 0.97
6 12 0.0027 0.38 12.6 1.6 1 23 731 754 731 754 0.96
7 12 0.00022 0.032 16.0 1.3 2 23 945 966 944 966 0.97
8 12 0.023 3.3 9.7 5.3 1 23 972 995 972 995 0.97
9 12 0.19 27 6.8 0.9 1 23 1025 1049 1025 1049 0.90
10 12 0.05 7.2 8.6 0.5 1 23 1071 1094 1071 1094 0.94
11 12 0.02 2.9 9.8 0.3 2 23 1134 1155 1133 1155 0.92
12 12 0.025 3.6 9.5 5.3 1 23 1161 1183 1161 1183 0.97

Sequence Information

Coding Sequence
ATGCAGGGAGCCGCAAGTGCACCCGCGCCTCCCGCGGCCGAACCGCCTGGGTCGCAACAAATCAAAACAGAGGTTATCAGCGAGGCCAAAGTCGAGACGGATAATCAGGAAGACCACATGAAAATTGAACAACAAGAAATGCGTGCGACGCGCACGACCAGCATCGATAGTGACAACAGATCAGACAGGAGTGAAGAGGAGGATTGCAGGCGAGCTCGGAAGAGAGCCGCATCGACGTCACCATCACCTATACCATTAGATAAAAAAACGACGCGTTTTGAGTGCCCCAATTGCTTACAGCGATTTGATTCAATAAACGCCTATGATCTTCATCGTTTCACGGCACACGGGGACGAAACCAGATCCGGGTATGATGACTATGTAGACTACTCCGGCAAGAAATTCGCAGATATGTTAAAAAGCCCTCACGTGTCTATCTCAGAGCAACGTTTTCGCTGCGAACATTGCTCTCGAGAATTTCcatctgtacaaatattagaTGTGCATAGGAAAACGTGTACTTCATCTACAAGGATCTGTAGTCCTGATCATGATCGGAGAGAAGATTTTTTCGCTAAATTGGATCTTAGAAATAGATCTTTTGGTTTACCAGGTACATTGACCCCACCGATGGATCGCTTCACACCTAAATTTGATGACGGTCACCTCACTAATGGTGTTAGACATATGGACGCCGCCAGAGACTTGGCAGATATTCAGTCTATTTTAAGCGTTACTTCTGCTGGAAGTCTCTTAGAAAGACTGACAGGAACGAAAGTTGCACTGGAAAATGCTGTTTTAACACCTCCCGATACAATTTGTAAAGAGCGCGAGCCTGATGAATCTCAGGACAATTTTGCAGCGGAGTTCAGACGAATGAAACTACGCGGTGAATTCCCGTGTCGATTGTGTCCCGCAAAATTTCCGAACCTACGAGCTCTGAAAGGTCACAACAGAGTTCACCTAAGTGGGACTGGTCCTGGCCCCTACCAGTGCAACATGTGCCCTCATGCATCATTAGACAAAGCTGCTCTGGTTCGACACATGCGCACACATAATGGAGACAGACCGTATGAATGTGCTGTTTGTAATTATGCCTTTACTACGAAGGCTAATTGCGAACGTCACTTACGTAATCGTCACGCCAAAGTAACGAGAGAAGATGTAAAACGCTCAATAATTTATCATCCATCGGAAGATCCTAATAATGATGAGGTTAACTCTAAAATAGCTAGAGATGAAGTTAAGAGATCGCTTGCTTTCCACACACCAGAAAATGAAAGACGCAGCGAACCTACGGGACGAAGCACACCGCTGACCCACTACAATCCTAGTTTCATACCCGATAGACATCCACTAACTTCACTCACTAAATCATTACCTGATTCACCCGCATTAACTCCCAGAGAATCGGAACCAATAATGCCTAGAATCAAAGTGAAGGGTATCGGACAACTCACACAAATACCTGAGTTTAGAACACCACAAATTTCGTTTAAATCGAACGATATACAACCGGAAACCTATAATGATGACGCTCCAGTTGATCTTAGAACAAGTGATACCAATAGTTGTGATGTATTAGATCTCAGCAAGAAAAAACGCGATACAGATGACGATGAGCCTAAGGCCGCATCACGCCCAGCTTTTGATAATTCAACATCTGTTGCAGCGACAGCTGCAGCAGCAGCTTTTGAAAAAACAAGATTACTTCTTGCTCAGCAAAGATTCATCGAAAACTCTTTTCCTAAAATAGATTCTACGTTATATGTAAATCAGTTATCACAACTCTACGCCAGTGCAGTGCCTGGTCTGCCTGGTCTACCTCTTCCACCTTCATTTCCAATCAATCCATACTTTCTTCAAACATCTTTTTTTCCACACCCAACCGATTCTCAGGAAATTGCAGAAATTAAGCAAAAAATACAGAAAGAAATCATTCGAGGGCTTAGTATGTCTGGGGGAAGATTAGTTAACGCTGAATCTGAAATTCAGCCAAAACAAGAACCTGAAGAAGAAGAACAAAAGCCTATTCATGTTTCCACAACGCCAACCCCACCTCCCCACTCAGAATCTCCACTTCCGATAACTAACAATGTTATTTCTCAAAACGATTCCGTGAAAATGGTGATAAAAAACGGTATTCTTATGCCCAAACAAAAGCAAAGACGTTATCGCACTGAAAGGCCATTTTCCTGCTCACAATGTTCAGCCCGGTTCACACTACGATCAAACATGGAACGTCACGTAAAACAGCAGCATCCTCAGCATTGGAGTGTCAGACGTCCAGCGCCGAGAGCGCCTCCGCCGTATCCAACTAATGACACATTGGCCGATCGTGTCAAATACGCGTTGCTGGCTCGTCATTTGGAAAGACCAATGCCCTCTGACCGCTCACCTGTCAGGAGAGATTCGGACGAAGTTGCTGACAATGAAGAAGATGAGGATGATACGTTAGTTATCGATGAGGAACCAGATGACCAGAAACCAGGTGAACATTCAGCCGCACATCGAGCTGCAGCGGAAATCCTCATGGCTACACGTCAGCAAGAAATGCATAAGGACTTTGATCTAAAAATAGCCGGGAACCTCATTAATAAACCAATCCCAATAACTACAGATAAAACCGAAACGGGAACAGATCCAATTTTAAGTCAAGATAATGTTCCGGTGGTACCAACTCGCAGTGACGAAGAAGAAGACGAAGAAGGCCTGGTCGCGTCTACTAGCGAGGGAAATAACTCTGGAAGTGATGAAAACAAGTCAGAATCTGATACTGGCACGCAACCACCGAAAAAGAAATCCGCGTATAGCCTTGCACCAAACCGCGTATCCTGTCCCTACTGTCATCGAAAATTTCCCTGGTCTTCATCCCTCCGACGTCACGTCCTAACTCACACTGGGCAAAAGCCTTTCAAATGTCCCCACTGCCCGCTGCTTTTTACCACGAAGTCTAACTGTGACCGCCACTTGCTGAGAAAACATGGAGGATCAGCTAAAGCCATATTGGCAGAACCTATCCGAGACTCCATGACCCCACAATCGAACGACAGAAGCGTACCAGAGAGACCATTTAAGTGCGCCTCATGTCCTACAAGCACATTTTCGTCCATGGAAACTTTGAAAAAACACATGGCCTCTAGACACGGGACAGGGGAATCTCAGCCAAGTTCGCCAAATCCTGAAGAAGAGGTAGATGGAAGCTTAGTCTTTAAGTGTCATCTCTGCGAGGGTTCGTTCAGTGACAGGACAGCGGCTTTGGAACACTTGGCTTCGACGCATGCGTCTGAATATGAACAGTTGGTCAGCAAGGGTGCCTTGGACGCTGCCAGCGATCGCAGTGAAAgcgctgatgatgatgatagagGAAAATTTCCTGACCATGCAAATAGAAAGGTCGTCTGCGCGTTTTGCATTCGTCGGTTCTGGTCAGCGGAAGATTTGCGTCGCCACATGAGAACTCATTCCGGTGAAAGGCCCTTTGCCTGTGACTTGTGTAGGCGACGGTTCACATTAAAACATTCTATGTTAAGACATAGAAAGAAACACAAAGACGAAACTGACGATGAAGAGTCACCACGAGAGGACACCACAAATGGTTATCGTTACCAAGAAGATGACGGCTCCGGCAACGAGATCCCTAGCAACGTGAACAACAACAACTCACCGCCATCCGCGCCCTTTGACAAGAAACTCAAACTGGAAATGACGTCGCGCAAATATTCATCTGAAACCGAAAATGATACTGAAAACGGAGGTGATCTTATCGGGAAACTACTTGGCATTCCCGACAAAACGATCATAAACAAACTACTTTCTTCAGCAGACGAAGCCGCTAAATTCCTCGGAGTAAACAAATGA
Protein Sequence
MQGAASAPAPPAAEPPGSQQIKTEVISEAKVETDNQEDHMKIEQQEMRATRTTSIDSDNRSDRSEEEDCRRARKRAASTSPSPIPLDKKTTRFECPNCLQRFDSINAYDLHRFTAHGDETRSGYDDYVDYSGKKFADMLKSPHVSISEQRFRCEHCSREFPSVQILDVHRKTCTSSTRICSPDHDRREDFFAKLDLRNRSFGLPGTLTPPMDRFTPKFDDGHLTNGVRHMDAARDLADIQSILSVTSAGSLLERLTGTKVALENAVLTPPDTICKEREPDESQDNFAAEFRRMKLRGEFPCRLCPAKFPNLRALKGHNRVHLSGTGPGPYQCNMCPHASLDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHAKVTREDVKRSIIYHPSEDPNNDEVNSKIARDEVKRSLAFHTPENERRSEPTGRSTPLTHYNPSFIPDRHPLTSLTKSLPDSPALTPRESEPIMPRIKVKGIGQLTQIPEFRTPQISFKSNDIQPETYNDDAPVDLRTSDTNSCDVLDLSKKKRDTDDDEPKAASRPAFDNSTSVAATAAAAAFEKTRLLLAQQRFIENSFPKIDSTLYVNQLSQLYASAVPGLPGLPLPPSFPINPYFLQTSFFPHPTDSQEIAEIKQKIQKEIIRGLSMSGGRLVNAESEIQPKQEPEEEEQKPIHVSTTPTPPPHSESPLPITNNVISQNDSVKMVIKNGILMPKQKQRRYRTERPFSCSQCSARFTLRSNMERHVKQQHPQHWSVRRPAPRAPPPYPTNDTLADRVKYALLARHLERPMPSDRSPVRRDSDEVADNEEDEDDTLVIDEEPDDQKPGEHSAAHRAAAEILMATRQQEMHKDFDLKIAGNLINKPIPITTDKTETGTDPILSQDNVPVVPTRSDEEEDEEGLVASTSEGNNSGSDENKSESDTGTQPPKKKSAYSLAPNRVSCPYCHRKFPWSSSLRRHVLTHTGQKPFKCPHCPLLFTTKSNCDRHLLRKHGGSAKAILAEPIRDSMTPQSNDRSVPERPFKCASCPTSTFSSMETLKKHMASRHGTGESQPSSPNPEEEVDGSLVFKCHLCEGSFSDRTAALEHLASTHASEYEQLVSKGALDAASDRSESADDDDRGKFPDHANRKVVCAFCIRRFWSAEDLRRHMRTHSGERPFACDLCRRRFTLKHSMLRHRKKHKDETDDEESPREDTTNGYRYQEDDGSGNEIPSNVNNNNSPPSAPFDKKLKLEMTSRKYSSETENDTENGGDLIGKLLGIPDKTIINKLLSSADEAAKFLGVNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00986645;
90% Identity
iTF_00825108;
80% Identity
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