Basic Information

Gene Symbol
IBTK
Assembly
GCA_036937285.1
Location
JAUPFZ010000016.1:13632921-13648705[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 4.7e-18 3.2e-15 57.6 0.0 6 79 550 621 545 625 0.91
2 4 9.1 6.3e+03 -1.3 0.0 86 106 695 715 686 718 0.81
3 4 7.4e-11 5.1e-08 34.4 0.0 9 106 744 845 738 849 0.76
4 4 6.4 4.4e+03 -0.8 0.1 79 106 850 877 846 880 0.87

Sequence Information

Coding Sequence
atgaataaaataagagAACTAGATTGTACAAAGAATTGTAAATCGAGACAACATGGTCATTCACTCACAAGTGCAATAACAAAGAGATCTGTCAGCGATGAGTCTCTTgccagttttattaaaaacaccTGTGCTAACTTTTCAAAGGCTTTTGACTTTGAgGGCCGCACAGCTCTACACATGGCAGCATCTAGAGGCAGGAATGCATTAATGGAATGGTTAATACGTCATTCCTCTGATGCATTTATAAATGCAAGAGATCGAGAATCTGGATACACACCATTACATCGAAGTATTTTCTATGGACAAATACATTCAGCGGTTTCTCTcatgaaacttgGCGTCAACACAGATATTTTGGATAAGGATGACTATAAGGCCTTAGAGCATGCTATGCTCGATAAGCACTATATGTACAAACTGTCAGGCTCGGAGCCTTGTGATACTTATGTCTGGGGCAGCAACTCCAATTACACCCTTGGCACTGGTTCTCATCAGCCACGGAATATTCCAGATCTTTTAACTAGCTTCAGTCGCGTTAAAGCCAATGTTAAACAGGTTTGTCTCGGTAAATTCCATAGTGTATGGGTGTGTGGTAGCGATGTGGGTGAAGTGTGGTGCGCAGGTCAACCTGCTCGAGCCGGGGGTCCGCACACAACAGCTCTGCGGCCCGTGCCTTTGAAACTCCCTGAACCATGCATACAAGCCGCTATTACATTGACTTCTACTGTGTTTCTGTTGCAAAGTGGTGCGGTAATCCAGTATACACTAAATAATACAGAAAATCCCAGTCCATCGACGGCtaaaaatccaacgacaattaaaCTAGCGTCAGTCAAGCCACTTATAAAGATATCCGAACCTTTGGGTATTTGCTCGGGACGGTGCCACGCAGTCGTATGGAACAAGCATGCTGTATACACGTGGGGAATAAATTTGGGACAATTGGGACATCCAGAAAaggataaaattatttctactcCGAAAAGGGTGGggatatcaataaataataaagaagaagCGAGCCTCCAACTAGTGGACGCGTCGGACGCTGCCACAGTGATCACGACCAGTCGGGGCGACGTTTATCTCTTACACAAGTTTTTGTGCAAGAAGATCGCTATCAAGCAAATAAATTTGCGTCAGGTATGCGTAGAAGCAAAAGTGAGCGAACAAGGATCATATTCTCGCGTCACCGTACTCCTTCTAACAAACGTTGGTCAACTTATGATATGGCAAGACACCACTAACAAACTGACTAGATGCGTATTCGGTATAAACCACCAAACAATAATTACTCATGTCGCACTCACACACGACGCTCTCTACTTCACGACTGTGCACGGCGAGGCGTACATTGGCAATATATCCCGCAAGACCACGCCCCCTCCCTCGCAGCCAATCAGGAAAGAGAAGGAAAAAGACAACAAATCCTCTCTTGTCACGTTTTTGAAAAAGGATGACTGTACTTCTGTTAGGATCACAAAGATTCCGAATATACATAGAGCGATTGCGATAAGTGTTGATAGTGAAGGACTTAATTTTGCTTGCCTTCAGATAAAACCAACATGTGGTTTGACATCACTGCCAGATTTATCACCATCAAATTTCTCAAAGCACATGCAATGTCTTCTTGAGACTGCTGCGGAAGATGATATTGTACATGATGTTGTATTTAAGGTTGGAGCAAAACATTTCCCAGCTCACATGTTCATAATCGCGTCAAGCAGTGACTATTTACACAAATTATACAAAGAAACAAGCACAAATGAGCACAAACCTACGATTATTCTAGAAAATGTCCATCCGGAAGTATTTGAAAGAATTATTCGTTTCATGTACACCGGAACTTGTGATGTGGCTGAATTAGGACCATGTGGGTTGAAGATAAGGAAAGAAGATCTGATTGGAGGgaataagaaagaaaaagaagatgTTGATAATGAAATTGATTTATTAGACAATCCTGCAGAAATATCAGCATTCGAAGTTTACAAGAAACAAGATAAAAAGAAAGGCAGTAAACGTCGTAACACTGAAACTCCACCTCGCACACATATGTACTGCGACCCAATTAAATTAGTTCAAGCAACGGCCAAAAGATTACAAGTTATGGGATTGCATAAATTGCTCGAAAAATTctattaCAGGGACGGAAATGTGTGCCTTAAAGAAAGCGCTACTTATTCAAAAAATGCACCTCTTACTTGGGATAGGGAGAGTTATCCCGAATTAGTGGATACCAATGTATTGTCTAAAGATGGTATACTGATACCGGCTCATAAATGTATCCTAGCTGCTAGGCTGGAGTACTTCCATGGCATGTTCATGCATTCTTGGACTGAGAGTAAACTGCTATCAAAAGTATCTCTACCATTCAATCATGGAATTCTTCAACCGGTTATAAATTTCTTGTACACCGATAAATGTCCAGACATTGAAAATTCAGACAGTATTGACTTTATATGCAGTATGCTCATTGTATCCGATCAACTTTTTATTGGTCGACTCAGGGAAATGTGCGAAATCGCTCTCGCAAATTTAATAACGTTGAAAAACTGCACTGAACTCTGTCAATTTGCCCACACGTATAACGCTACTCAGCTAAAACGGTGTTGCATGGAGTATATATCTCTTAACATATGCAGTATCCTTGAAAATAGATCATTGGACCCGCTAGAAGAAACGTTACTTGGAGATATTTCGAAAtactattgtaaatttaatCCCATTATGTCATCTCGAGTGATAACACCTTTCTACAATTCGCCTAGCGATGAAATCATCAAGGAATGCTCCAAAAACTTTCCAGTAGATTTAGATGTTTTGGACGAAGATGTCAAAAAAGACGACAGCCTCGTTGaagtaattaaaaagaaaaaaaagaaaatcgagTACACTGAAAACGAGAAAGCGAGGATGAGATATGAATCAGTTAGCTCTGTGAATTCATTGGACCTGTCTCATGATACCTCCGGTGACGTCACACTATCACTCAATGCCATTTCTAGGAACGGAGAGAATAAATCTCAAGATACAGGTAAATGGACAGAAGTCCCGACATCTCAACAGAAGCAACAAAAAGTTGTGCAAGCTCGTTTGAAGGCGATATCTTCTGCTAAAGACATTCTTAATGAAAGTCCTGCCAATTCTTTTACTAAACTTACCAAGAATAATTCTTATAGTGCCATTATACAGGAATCTCCAACACCAACTACTTCTCGCATGTCTGTATCTCCTAAAGATTCACCATTATCTGAATCTAGTTGGGGTCAAGGAAATCTAGTCATTAATCATGTCGGGCCTAAGCTCTCTCAAAAGCAAAGAAAGAAATTGGGGACTGAACAAACATCTACCCAGACACTGGATAATTACTTCAATAAACTGAACATTGGTAGTCCACCAGACAAACCAAAGAATCCTTGGAAGATTTGTGAAACACCAGTCGCCAATAGCAGCCCAAATAAACCAAATGCCATggaatttgataaaatattagcTGATCAGAAAAAACAGAAGAATGATTTTTCAAGAATCATGACAAAACCACTCACTTTAACACAGCTCGAAGATAAAGCTATTGAGGAATTGGAAAGATTCTACAATATACATGATGTTGATGATGAATTGATAACAGTGAGGCGTATTGAATTACAAGTATCGTCTCCACAATGGATCCATGCTGCCCCAAAGTGA
Protein Sequence
MNKIRELDCTKNCKSRQHGHSLTSAITKRSVSDESLASFIKNTCANFSKAFDFEGRTALHMAASRGRNALMEWLIRHSSDAFINARDRESGYTPLHRSIFYGQIHSAVSLMKLGVNTDILDKDDYKALEHAMLDKHYMYKLSGSEPCDTYVWGSNSNYTLGTGSHQPRNIPDLLTSFSRVKANVKQVCLGKFHSVWVCGSDVGEVWCAGQPARAGGPHTTALRPVPLKLPEPCIQAAITLTSTVFLLQSGAVIQYTLNNTENPSPSTAKNPTTIKLASVKPLIKISEPLGICSGRCHAVVWNKHAVYTWGINLGQLGHPEKDKIISTPKRVGISINNKEEASLQLVDASDAATVITTSRGDVYLLHKFLCKKIAIKQINLRQVCVEAKVSEQGSYSRVTVLLLTNVGQLMIWQDTTNKLTRCVFGINHQTIITHVALTHDALYFTTVHGEAYIGNISRKTTPPPSQPIRKEKEKDNKSSLVTFLKKDDCTSVRITKIPNIHRAIAISVDSEGLNFACLQIKPTCGLTSLPDLSPSNFSKHMQCLLETAAEDDIVHDVVFKVGAKHFPAHMFIIASSSDYLHKLYKETSTNEHKPTIILENVHPEVFERIIRFMYTGTCDVAELGPCGLKIRKEDLIGGNKKEKEDVDNEIDLLDNPAEISAFEVYKKQDKKKGSKRRNTETPPRTHMYCDPIKLVQATAKRLQVMGLHKLLEKFYYRDGNVCLKESATYSKNAPLTWDRESYPELVDTNVLSKDGILIPAHKCILAARLEYFHGMFMHSWTESKLLSKVSLPFNHGILQPVINFLYTDKCPDIENSDSIDFICSMLIVSDQLFIGRLREMCEIALANLITLKNCTELCQFAHTYNATQLKRCCMEYISLNICSILENRSLDPLEETLLGDISKYYCKFNPIMSSRVITPFYNSPSDEIIKECSKNFPVDLDVLDEDVKKDDSLVEVIKKKKKKIEYTENEKARMRYESVSSVNSLDLSHDTSGDVTLSLNAISRNGENKSQDTGKWTEVPTSQQKQQKVVQARLKAISSAKDILNESPANSFTKLTKNNSYSAIIQESPTPTTSRMSVSPKDSPLSESSWGQGNLVINHVGPKLSQKQRKKLGTEQTSTQTLDNYFNKLNIGSPPDKPKNPWKICETPVANSSPNKPNAMEFDKILADQKKQKNDFSRIMTKPLTLTQLEDKAIEELERFYNIHDVDDELITVRRIELQVSSPQWIHAAPK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01507342;
90% Identity
iTF_00985273; iTF_00986360;
80% Identity
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