Eedi005998.1
Basic Information
- Insect
- Euphydryas editha
- Gene Symbol
- tc1a
- Assembly
- GCA_036937285.1
- Location
- JAUPFZ010000005.1:1710741-1711760[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.4e-07 0.00017 22.8 2.2 21 125 10 109 4 109 0.88
Sequence Information
- Coding Sequence
- ATGGGAAAAGTTCCGGAAATTAGTGTTGAAACGCGATCTGCCATCGTTGTTCTCCACAACGAAGGCAAATCTGAACGTCAGATAGCGAGTCAACTCAAGTTATCGAAGACTGGTGTTCATCGCACTATTGTGCGCTACAAACAAACCGGCAGTAATCAAGATCGTCCGCGCTCTGGGAGACCAAAAGCTACAACTTCTAGTGAAGACAAATTTATTGTGGTGACCAGCAAGCGGAATAGACGTCTGACAGCCCCAGAAATTCGTGTAGAAGTCAACAAATCTCGGGAAAAACCTGTGTCAGTGTCTACAGTGCAAAGACGATTGCGAGACGCCAAGTTGTTGGGCCGCGTTGCTGTGCGTAAACCTCTGTTAAAACCGCAGAATAAAAAGAAACGGATGCAATGGGCCCTAACCCATCGAGACTGGACCGAAGAAGACTTCAGAAAAGTTCTTTGGAGTGACGAATCAAAATTAGAAGTGTTCGGGTCAAAAAGAAGAATTTTCGTCCGACGCTCCGCCGAAGAAAAGATGATGCCGCAGTGTGTAGTGCCGACTGTCAAGCAAGGTGGCGGATCTGTTATGGTCTGGGGTTGTTTCTCTGGCTATGGGATTGGAAATCTAGTCCAAATCAAAGGCATAATGAAAAAGGAGcaatataaagaaattttggAGAAAAACGCCATTCCCTCCGGACTAAAGTTAATCGGCCGTGGATTTATTTTCCAACAGGACAATGATCCAAAACATAGTTCGAAATTATGTAGAAGCTATTTAGACAAAAAACAGTCGGAAAAAGTATTAGAAAACATGACCTGGCCACCTCAAAGCCCCGATCTTAATCCCATTGAACTTTTGTGGGAAGAGCTCGATCGAAACGTTCGGGAACAGTGTCCATCTTCACAGCAGGCCATGTGGAATGCATTGGAGGAAAGCTGGAATAATATCTCGCAAGAGACTATAGATAAATTAATTGCTCGCATGCCTAGATTAGTAAAAGAAGTCAAAAAGTGCAGTGTGTGA
- Protein Sequence
- MGKVPEISVETRSAIVVLHNEGKSERQIASQLKLSKTGVHRTIVRYKQTGSNQDRPRSGRPKATTSSEDKFIVVTSKRNRRLTAPEIRVEVNKSREKPVSVSTVQRRLRDAKLLGRVAVRKPLLKPQNKKKRMQWALTHRDWTEEDFRKVLWSDESKLEVFGSKRRIFVRRSAEEKMMPQCVVPTVKQGGGSVMVWGCFSGYGIGNLVQIKGIMKKEQYKEILEKNAIPSGLKLIGRGFIFQQDNDPKHSSKLCRSYLDKKQSEKVLENMTWPPQSPDLNPIELLWEELDRNVREQCPSSQQAMWNALEESWNNISQETIDKLIARMPRLVKEVKKCSV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00960900;
- 90% Identity
- iTF_00695524; iTF_00695537; iTF_00695538; iTF_01127362; iTF_00695557; iTF_00695528; iTF_00166891; iTF_01127371; iTF_00695565; iTF_00695536; iTF_00695539; iTF_00695540; iTF_00695541; iTF_00695542; iTF_00695543; iTF_01127360; iTF_00695571; iTF_00458015;
- 80% Identity
- -