Basic Information

Gene Symbol
ZEB2
Assembly
GCA_900480035.1
Location
UELX01001753.1:32056-38486[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.00087 0.098 13.7 7.0 1 21 289 309 289 310 0.96
2 14 0.00035 0.039 15.0 2.0 1 22 327 348 327 350 0.91
3 14 0.11 13 7.0 0.5 2 21 359 378 358 379 0.92
4 14 0.0014 0.16 13.0 0.4 1 20 390 409 390 411 0.94
5 14 0.081 9.2 7.5 1.8 1 23 419 442 419 442 0.95
6 14 0.009 1 10.5 1.8 2 21 452 471 451 472 0.94
7 14 0.0037 0.42 11.7 4.9 1 23 480 503 480 503 0.97
8 14 1.7 1.9e+02 3.4 3.7 1 21 724 744 724 745 0.94
9 14 0.0014 0.16 13.1 2.5 1 23 753 776 753 776 0.95
10 14 0.00022 0.025 15.6 0.5 1 21 785 805 785 806 0.94
11 14 0.0017 0.19 12.8 1.5 2 23 815 837 814 837 0.95
12 14 5.3e-05 0.0059 17.5 0.4 1 21 845 865 845 866 0.95
13 14 0.057 6.4 8.0 0.2 2 23 875 898 874 898 0.95
14 14 0.058 6.6 8.0 5.4 1 21 907 927 907 928 0.94

Sequence Information

Coding Sequence
ATGATGGACCCTAAAACCATCGAATACCGGGCGATCCTGCGCTACAACTACAGTCGCGGCCTCAGTTTCGGCGACTGCCACGCCGAGATGCGCAACGTGCTAGGATCGGATTGTCCGGCTCGCGACACTGTTTATCGCTGGTACAAGCAGTTCGCCAGCGGTTGCTTCAGCATCAGCGACAGTCCACGCAAGGGCCGACCACCTAAAGCTGTTACTCCAGAGAAGGTGGCGGAAGTGAAGAGGCTCGTTGAAGAGGATGCGAGAGTTACTTATAAGCAGATCGAGGCAAGGCTGAAGATAGGTGCACCGGCGGTTAGGACGATACTTAGAGATCTCGGATTGAGGAAGAAGGGTTTGAGGTGGGTAGCTTCGCAGAGGAGCGTGGCGTTGGAGGATCGAGAGCGCGAGGATCCAGatgTAGGAAATGAATTCTTCTTCAAAACTGAAAATGACAATGACATAAATAACAAAGACAATCAAGCTAATACTAGTCAAATATATGATCATCAAAATAGCTCGAACATAAATTTAGAAAgtgaaagttttattgttgtaaaagaagaaattgaTGAGAATGTAGTAAATAACAACGAAGATTTTTCATGttctaatacaaatatttcaatttctgcCCCCATTAAAGAAGAAGATCCACTCGACATTATTGACGAAAACTTATCTGAAATTGATACAAATGACATTACTAATGTTAATATACGAATAAAAACGGAAAACCTTCATGACGAATGTTTgactaaaaataacaatgatacTGAAACTGGCAGTGACCGGTCCAACCAAACTTTAGCACAAAAAAGCTCGCCAACGTCGTCAAAGGGCGAGCATTCGACCAGCGAGAAGCGATATCCCTGCAAGTATTGCAAGAAGACCTACAAGCACAAGACCCATGCGAATCGCCACATGAAGCACGAGTGCTGGGTGGCTAGGGTAAAGCAGGGCGACACAGACAGGGCGCGTTACAGCTGCGAGCTTTGCAATGCCAACTTCACGTCGAATTACAGCTTGACTCGGCATCGGTTCTTTCTGCACTCGGACGGCCGCCGCAATAAGACTTCGTGCGGCGTCTGTCTGAAGCTGTTTTCCTCGCAGAATTCGCTCGATCATCACCTCAGCAGCAAGAGGTGCGGCGGAGCGCCGGCCAACGAGTTTGTCTGCGGTACCTGCAACAGGCGATACCGCGACATGACGAGCCTGCGTCGCCACGTGAGCAACGAATGTGGCAAGGAACCGCGCTTTAGTTGCGCACATTGCGACTACCGCAGTCTACAAAAAATCAATCTGGTCAGGCACTTGTCACGCATGCACGGTACCCAGTTTGAACTGATCAAGGTCTCCTGTCCAAGCTGTTTTAAAGTCTACAAAAACGAGTGTACCCTGAAGCGCCACCTACAGTTCGAGTGTGGCAAGGAGCCGTCGTTCGCCTGCAAGCTCTGCAGCTATAAAACCAAACGAAAGTCTTGCCTTACATCGCATGTTAAAACCTTGCATTCTAAAAAGGAATTCAAGAaaGGCGCTGTAAACAAAACAATTCGGACTACAGAAGCAGTCCAGATAAAAGTTGAAGACGTCAGTATCTCAGATGATTCATTGATACTTGATACATCTAATGacttaaatgAAGAAGAAAATTGTACCAATGTATTTGAAACAAGCCGGACTGATATCGAGTTTATAGATACAGATGCCTTATACGAAATTTCAGAGAATTTAGataaaataatacaaaagaaatttgaatgCAAGAAAAAAGTactcaaaaataagaaaaaatctggAATCCCcacttacaaaataataaacaccaGAAAATCTGTAAGAGACAGCAACAAAGATGTAAATACGAAACAACCGATAAAAGACAGTACCAAAGTTATGAGCGCGAAGAAATCGACAAGAGGCTGTAACAAAGATGTGAGTCCGCAAAAACCGGAAAAAGACAGTGACAAAGTTGTTGATACACAAAGACCGATAGAAGACAGAAACGAAaatgtagaaaagaaaaaaatttcaacaaaaagaaTGACGGCAGCAactaaattttATCTTCATAACTTGCTAGTACTGTATTGCCAAAAATGCGACGTggttcaaaaaaaaatctacggGAAGAAGCAGATCAATTGTCCACGGTGTGATGAGTCTCTACAATACCAGTGTATTAAATGTTCTAAGCGATACCGTAACTATTGTGACATGACAATGCACCTGAAGTACGACTGCGGTAAACCCAAGGGGTTTTTTTGCAACATATGTGACTACAAGACATCGAGAAAGAGTCGGCTCAATGATCACTTTAAGTCTGTGCACACATTCTATAATCACAATGATCTATTCAACTGCGCGGTGTGCGGTAAAACCTTTAAGTTGCTCAGATACCTCAGATGGCATCAGAATCGTGAATGCGGCCTAACTGAGCATCTTCAGTGTCCTTATTGTGACTTCAAAACCAAGTATACCAACTCGCTACGTAAACACGTTAAAAATATCCACAATCGGGACGAAAACGCATTTTTCGACTGCGAGAAGTGCGGGAAGGTGTACAAAACGAGGGGAGCCCTGTTAAATCATGTGAGACATCTATGTGGCAAAGAGCCGCGCCTGACGTGCGATTATTGTGGTTATAAAGCCTTTCAAAAGTATCCGCTCTTGGCTATCCACATACAAAGAAACCATCCCGACGCCTTTCCCGAGAAGGAGTTCTTCTGCAAGCATTGCAACACAAACTATCATAATTACTACGGACTGACCCGCCATTACAAGATGGCTCTCATATGTCGTTTGAAAGAGAAGAGTTtgaagagaaagaagaattaG
Protein Sequence
MMDPKTIEYRAILRYNYSRGLSFGDCHAEMRNVLGSDCPARDTVYRWYKQFASGCFSISDSPRKGRPPKAVTPEKVAEVKRLVEEDARVTYKQIEARLKIGAPAVRTILRDLGLRKKGLRWVASQRSVALEDREREDPDVGNEFFFKTENDNDINNKDNQANTSQIYDHQNSSNINLESESFIVVKEEIDENVVNNNEDFSCSNTNISISAPIKEEDPLDIIDENLSEIDTNDITNVNIRIKTENLHDECLTKNNNDTETGSDRSNQTLAQKSSPTSSKGEHSTSEKRYPCKYCKKTYKHKTHANRHMKHECWVARVKQGDTDRARYSCELCNANFTSNYSLTRHRFFLHSDGRRNKTSCGVCLKLFSSQNSLDHHLSSKRCGGAPANEFVCGTCNRRYRDMTSLRRHVSNECGKEPRFSCAHCDYRSLQKINLVRHLSRMHGTQFELIKVSCPSCFKVYKNECTLKRHLQFECGKEPSFACKLCSYKTKRKSCLTSHVKTLHSKKEFKKGAVNKTIRTTEAVQIKVEDVSISDDSLILDTSNDLNEEENCTNVFETSRTDIEFIDTDALYEISENLDKIIQKKFECKKKVLKNKKKSGIPTYKIINTRKSVRDSNKDVNTKQPIKDSTKVMSAKKSTRGCNKDVSPQKPEKDSDKVVDTQRPIEDRNENVEKKKISTKRMTAATKFYLHNLLVLYCQKCDVVQKKIYGKKQINCPRCDESLQYQCIKCSKRYRNYCDMTMHLKYDCGKPKGFFCNICDYKTSRKSRLNDHFKSVHTFYNHNDLFNCAVCGKTFKLLRYLRWHQNRECGLTEHLQCPYCDFKTKYTNSLRKHVKNIHNRDENAFFDCEKCGKVYKTRGALLNHVRHLCGKEPRLTCDYCGYKAFQKYPLLAIHIQRNHPDAFPEKEFFCKHCNTNYHNYYGLTRHYKMALICRLKEKSLKRKKN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00690582;
90% Identity
-
80% Identity
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