Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00017 4.3 9.6 0.0 17 51 39 73 34 76 0.92

2 6 0.0005 13 8.0 0.2 26 47 85 106 73 112 0.82

3 6 0.011 2.8e+02 3.8 1.2 27 46 132 151 128 153 0.89

4 6 0.00091 24 7.2 0.1 21 49 154 182 150 185 0.90

5 6 2 5.2e+04 -3.5 0.0 21 30 211 220 203 228 0.72

6 6 3.9e-05 1 11.6 0.6 15 51 289 325 282 327 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00017	4.3	9.6	0.0	17	51	39	73	34	76	0.92
2	6	0.0005	13	8.0	0.2	26	47	85	106	73	112	0.82
3	6	0.011	2.8e+02	3.8	1.2	27	46	132	151	128	153	0.89
4	6	0.00091	24	7.2	0.1	21	49	154	182	150	185	0.90
5	6	2	5.2e+04	-3.5	0.0	21	30	211	220	203	228	0.72
6	6	3.9e-05	1	11.6	0.6	15	51	289	325	282	327	0.86

Coding Sequence: GCGTCTCCGTCGCCACCGCCGTCGCCATCGCCTTCTTCAACGCCCTCGCAGAATCAACAGAAACAAGAAAACACCTCGGCCGATGAAGAAACCGAGATCGAAGCGGAGGATTATTCAGAGTCGCAGCAGGAATTTACATACATGTGCGGCGTGTGCGATCAGCTGTACGACGAAGAGCTTCAATTGATCCGTCACCTGCGTCTAGAGCATAACGCGAGGGCCAGCGACGGCTCTTCCAAGCCTGTACGCTACGAGTGTAACATCTGCAGCAAGAGCTTCCCGCAGAAACAGAACTTGCTCAGGCATCTGAAGATGCACGAACGTGAGGAACCCTCCGATGTCAAAGCTTGCAATGATGCCAAGGTCATGGTGAACAATATGATGTGCTACAAATGCAAGCAGTGCAACCAAATACTGACCAATCGTCGAAACTTTCAGCGTCACTTGCGTGTCCACTCAGGTGAGCGGCCGATCATCTGCCACTTTTGCGGCAAAAGTTACCGAGCTACGGACGACCTGAAGCGCCATATCGACGACGTGCATTACAAAATCAAGCGCTTCTCGTGCGATATCTGCGGCACGTCGTTTGCCGCCAAGGCGACCCGTGACGCTCATCGAAGAATTCATACGGGTGAAAAGCCGTTCATGTGCGCACAATGCGGCAAGAATTTCAGGTCTATAAATCTGCTGGGCATACACAAGCGCACGCACACCGATTACAGGCCGCACAAATGCAGTTACTGCGAAAAGGCGTTTAGAGTCAAACAGAAGCTGACAATTCACGAAACCATTCACACTGGAGTTAGGCCCTTCGCCTGCGACGTCTGTGGCAGGATGTTCTCCGCTAAGGGTGAGCTCGGCAGGCACCGGAGCGTACACTTCGATGAAAGGCCTCATCAGTGTTCCCTCTGCGGCGTGGGATTCAGGTTGCGTCGCTATCTTAGGACTCATTTTAAGATACACCACAAGGATAAGGCTGACGAGCTGCTCAAGGCCCTGGATGatcgttaa
Protein Sequence: ASPSPPPSPSPSSTPSQNQQKQENTSADEETEIEAEDYSESQQEFTYMCGVCDQLYDEELQLIRHLRLEHNARASDGSSKPVRYECNICSKSFPQKQNLLRHLKMHEREEPSDVKACNDAKVMVNNMMCYKCKQCNQILTNRRNFQRHLRVHSGERPIICHFCGKSYRATDDLKRHIDDVHYKIKRFSCDICGTSFAAKATRDAHRRIHTGEKPFMCAQCGKNFRSINLLGIHKRTHTDYRPHKCSYCEKAFRVKQKLTIHETIHTGVRPFACDVCGRMFSAKGELGRHRSVHFDERPHQCSLCGVGFRLRRYLRTHFKIHHKDKADELLKALDDR

Sequence clustering based on sequence similarity using MMseqs2