Basic Information

Gene Symbol
RREB1
Assembly
GCA_001483705.1
Location
NW:678463-706928[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.0029 0.16 11.7 0.1 1 23 39 61 39 61 0.96
2 16 0.00013 0.0069 16.0 0.1 1 23 75 97 75 97 0.98
3 16 6e-07 3.2e-05 23.3 1.2 1 23 103 126 103 126 0.98
4 16 0.0086 0.47 10.2 0.0 1 23 220 244 220 244 0.95
5 16 0.054 2.9 7.7 3.0 2 23 250 272 250 272 0.95
6 16 1.4 76 3.3 0.6 1 19 328 346 328 348 0.89
7 16 0.15 8.1 6.3 0.1 1 23 462 484 462 484 0.96
8 16 2.1e-05 0.0011 18.4 0.3 1 23 493 515 493 515 0.98
9 16 0.00093 0.05 13.3 2.8 1 23 521 544 521 544 0.97
10 16 0.00034 0.018 14.6 3.0 1 23 922 945 922 945 0.97
11 16 0.00049 0.027 14.1 0.1 3 23 1224 1244 1222 1244 0.97
12 16 0.44 24 4.9 6.0 1 23 1250 1273 1250 1273 0.97
13 16 0.0031 0.17 11.6 2.2 1 23 1311 1335 1311 1335 0.97
14 16 2 1.1e+02 2.8 4.8 1 23 1419 1442 1419 1442 0.94
15 16 0.0084 0.45 10.3 0.4 2 23 1493 1514 1492 1514 0.94
16 16 0.99 53 3.7 8.2 1 23 1520 1542 1520 1542 0.98

Sequence Information

Coding Sequence
ATGGATTACTCGACGAAAGTTACTGTTAAGAGTGGCCCCGATCAGGGACACGAGAACGAAGCACAAGCTGATGCTGCATCGTCACCATCGAGTGTCGAGTTACCAGAAAGCGCGCATCCCTGTCCAGCCTGTCCCACCGTGTTGCCTACCTCCAGGGAGCTGACGAACCACCTTCGTGGCCACAACTCGCCTCGCAGCACAGACTGCAGCGGTGAGGATGACTACAGCTGCGGAGTGTGCAACAAGGTGCTCAGCTCGGCGAGCTCTCTGGACAGGCATGTGCTGGTGCACTCGGGAGAGCGTCCGTTCAAGTGCAAGTATTGCGAAATGGCGTTCACCACGAATGGAAACATGAACAGGCACCTGAGAACGGCGCACAGAGGCGCCTCGCCTCATAGCTGCACGGACTCCGAGGGCAGCAGCGACTCGGAGAAACCGTCCAAGAGGCGCCACCTCGAGGAGTACAACAACAACGAAATCACCAAGAGGAACTCGCCGGACTTCATGGAGAGACGGGATGAAAAGTCGCCGACGTTATCTGGGAAGAGAAAATGTTCGGATTACTTGAGCGATAACGAGGGTCAGAAAAGGCACAAGATTCTCTTGAACAGCTCGAGGACCGAGATGAAATCGAGACCGGATGACAGCCAGAACGTGTACAATTGCCCGGTATGCGGTAGACAGGACTTCGCCACTAGCGCCCTCTTGGAGGCCCACTTGGAACGAAGTCACCCGGAATTCCCGGCTAAGTGCGATACCTGTAACTTGTCCTTCAAGAATCACAGAGTACTGAATCTGCATCGGTTCATGATCCACTTCGCTGAGCATTCCATAGGGAACACCGCGAGGAACTTGAGAAATTCGGTAGTGGGTTTCAATGACTTGACGTTCGTTGATTTCTCGTCGGATAAGTTCCCGGCGATAGCCAGGGCTGTTTGCGAGCAGTCTCTGCACCGACCTGCCTCCGGGGAAGTGGCCAAGTTCCAGTGCTCCAAGTGTCTGCGGGCATTCCCGTGTAGATCCGCGTTGGATGCCCACGAGACAGACTGTGGCACGATAAATTCTCAGATCAGGACGACGGACGACAGTCAGTCACGGAGAGACGACTTCTTCGCTGGTCTGGATCTTCAGAACAAGGCTGCTCTGACGGAAGCCAAAGAGGGGAAAGACCTGGCTGACATACAGAGTATCATATCTGTCACCTCTGGCCCTATTCTTCAGAATTTCCCTCGATCAGACGCTAGCACACCTGAAAATAACATCAAATTCAATCCCAGTGTGAGTTCCTCTGGCTCCTCGGGCACCTATTCGTCAGAGTACCACGAGGAGGAAGCTCAAGATGCGTTCGCCGCTGAGTTCAGGAAGATGAAGCTGAAGGGAGAGTTCCCCTGTAGACTCTGCTCTGCGATATTTCCCAACCTGAGAGCGTTGAAGGGTCACAACAGGGCACACATGGGTGTAGGGCCTGGCGTGCCTTATCCCTGCAACATGTGTCCCTACACCAGCACTGATAAGGCGACCTTGGTTAGACACCTGAGATCCCACAATGGTGACAGACCTTACGAGTGTTCGCTCTGCAATTATGCCTTCACCACTAAGGCAAATTGTGAGCGCCATGTGAGGAATCGACACGGGAAATTGACCAGGGAGGACATCAAGAGCGTTCTGATCTATCATCCAAACGAGGACTCCACGAATGAGAATGTGGAAAGAAGTTCTCCCAGAGTTTTGAAGGACGAAGTGAGGAAGAGTCTCGTTTATCCATCTGAACGCGATGATCTGCAGCATCAGACACAGATGCACTATCCCCCGGTGCCCATGGAGGTTAGGGGAGAGATCAGGATAATAGAGGAGGCGAAGCTGCACAATTCCACGATGTCGATGCACAACTCGAACCACTTCGAGAAGAACGACACGTTTTCGAGGCCAGGCCAGCCCATGGAGCTGATCCAACGGAACGCTGAGGAGGGTAAGCCCGGTCAAGACGCCAAGTCGGACTACTCGAAGCTAGACGATGATTTGGAGTCGAGGTCGTCGGAAGGCAGCGTGTCTCTAGTCAGTGATACCAAATCAGAATCGCACCAAAGAATACAAGCTAGTCCGATGAACTTGAAGAAGGGTCTGAACCTGCCCGAGAATGCCGGCGAAGATGGACCGTTGGATCTCTCTATGGATGTGCTGGACCTCAGCAAAAAGTCGAAAGGGAAGGAAGACAGCGACTTTTCTGCGTCTCACGAACAGTTCGGCAAAAATCAGAAAGACTTGTACAATGCTACCAGTCAGTTACTGTTGACCGAGGCCCTGTTGAAAGCTGGCCAGGGTAGTTCCCAACCTACCTCTCTGGAAGCACTGTACGCTAATGCCATCTATAGGAATTTCAGCACGTTTCCAGCTGGCGTAGGAGGAATTTTGCCACCGTACGTGTTCAATCCTCACGTCTTTGGACAAGACTTCTCTATGAAAGACAGACTGCAAAAGGAATTGGTCAGAGGTCTTCAGTTGACCAGTGGTGGCACTTTAGTGGAGTCATCTATCGGTGGAGCGGCGTTCACTGCTTTTTCCCAAGGCAGAGACATGAATTCTCAGTCCACGACCGAGCAAAACGAATATGCCAAACTGATATCGGCCAAGATGGCGAACAAAGGCCTGTCAAACCGCGACAAACCGGATAACTTACCCTCCTCGAATTCTGTAAAAATGGTAATCAAAAATGGAGTGCTGATGCCCAAGCAGAAGCAACGGCGATACAGAACCGAGAGACCGTTCACCTGTGAGCATTGCTCTGCGAGATTTACCTTGAGGAGCAACATGGAGAGACACATCAAGCAGCAGCATCCTCAACACTGGAGCCAGAGGCCCAGAGGAGGACACTCGACCAGGGGAAGACCGCCTTCCAGCCACCCCACGTTGTTACAGAATCTTGGACAGCCTGCTTCTCAAGTCACCCAGTCATACACCAACATCCTGCCAAAAGTTGAACAGCCAGTGAACTCGGAACTAACGAAGCACTCTATCTCTGACCAAGTGAAGTATGCTATTCTGGCGCAGCAGCTCAAGGCGAACAAAGTGGAAGAAAATGATTCTGAAGAAGAACTAGTGATAGACGAGGACCCACAAGAAAAAGAGAGTCAGGAATCTCAGAATCAGAAGGAGAAAAGTCTATTAAGGGGACAGTTGGAGGGTACAGAATCTACCAAAGAAGCAGCGGTGAAGGAGGAAGCGAAAGAACCGCCGAAAGAAGTCTCACAGGAGACAAATGCCGAGTCTGAAAAAAAGGAAGATACTGATACCGAAGAAACGAAGTCGACTGAGTCGGAGAAGCCCACTGAAACGGAAAAGACAACGGATGAAAGCCCCAGCAGAGTGTTCAAGACAGAGCCGGTTGAAGTGAAGAGCGAGAAAATGGAAGATGGAACAACTGACCTGGCCAGCGTGTCGGAACTATTGGACAACGCTTCTCAACAGTACCAGCAGTTTCAACCGCAATACCTGAGTGACGAGGAAGGTTTAGTGGCGTCCAACAGTGACTGCAATAACTCCGGCAGCGACGAGAAATCCGACTCTGTAAATTCGTCAAACTCGGTAAACACCTCtgcgaaaaaaaagaagaaaaagaagaagaagaagaagaagaagtctGCCTACTCGATGGCACCCAATCGAGTCATCTGTCCGTACTGTGAGCGGCCATTTCCTTGGACCTCGTCTCTCAGAAGACATATCCTCACACACACAGGACAGAAACCTTACCAGTGCGTCCATTGCTCGTTGCTGTTCACCACCAAGTCCAACTGCGACCGTCACTTGCTGAGGAAGCACAAAGCAAACCCCAACAAGATGCGTCGGGTGAGGAACTCCTCTTCTCCCGATTCCCAGGCAGTgagcaacaacaacaactcgTTTTCCATGAGAAACGTACCTGAAAGACCATACAAATGCAATCAATGTCCTAGCTCGACCTTTTCGACGCTGGGTAATCTGAAGAAGCATCGTTCTACTAAACACGCTCGGAAAATAAAGTCCAGATCGGACACTCCATCCAGCGAGCCCCAGAACAGTCCTCAAGAGTGTTCAAAGCAGAACAACGAACAAAGCGACTACGACAGTCAATCCTCTAGCGTGTCCGAAGGCATGGAAACCTCTTCGATGCCGGGACTTCCCAAGTCAAATTCTAACACTTCACCATCGACCAACGACACGCCCAGATCCAGGAGACCTTCGCCGAGGTCGTCACCTGGACCCAGCGATGTACCCTTCAAGTGCCACCTGTGCGACTGCGGTTTCGCAGAGCGACAGGACTGCTTGGAACACATCAAGGTGAATCACAAGAGGTCCTATGAAATGTTAGTGGCAAAAGGAGCTCTGGATATGGACATTGACACGGTAGAGGACCAACAGCAACCACCGCCACAACATCACGCCAGCGATGGAGAGGAGAAGAGAGGACGTTTTCCAGACTACAGTAACAGAAAGGTGGTCTGCGCCTTCTGCATGAGGCGGTTCTGGTCCGCAGAGGATCTTCGTCGCCACATGAGAACTCACACAGGGGAACGACCGTTCTCCTGCGATATCTGCTGTAGAAGGTTCACTCTGAAGCATAGCATGCTACGACACAGGAAGAAGCACGAGTCCATCGACTCGACCATGTATGTTGGCACCAGTGGCGACGAGGAAAATTCGCCGACACAGCCACCTACAATCACTCCGCGAAGCCAGCAGCAACCACCGATCCTGGTGGCGGCGAACAGCGGAAATTCTCGCATTCAGGACAGAATTTCTTTACCGACTGTTGCTCCAGTCGCGACCGGTGATGCAGCGCCAAGCGGACTGATGAGATTCAATCCGTACGAGAAGTTAACTACTCTTACGGGAAAACTAGCCAGTATTCCGCAAAATGTGAATCCAGACGCGAGCGAGAGCACGGACAACGACTTGATTTCTAACCTCCTGGGAATACGGGACAAGAGTTTCATCGACCGAGTACTTCAAGCGTCCGCCGATGACGCCGCCAAGCTATTGGGAGTGAAACGTAGCCATGAGTGA
Protein Sequence
MDYSTKVTVKSGPDQGHENEAQADAASSPSSVELPESAHPCPACPTVLPTSRELTNHLRGHNSPRSTDCSGEDDYSCGVCNKVLSSASSLDRHVLVHSGERPFKCKYCEMAFTTNGNMNRHLRTAHRGASPHSCTDSEGSSDSEKPSKRRHLEEYNNNEITKRNSPDFMERRDEKSPTLSGKRKCSDYLSDNEGQKRHKILLNSSRTEMKSRPDDSQNVYNCPVCGRQDFATSALLEAHLERSHPEFPAKCDTCNLSFKNHRVLNLHRFMIHFAEHSIGNTARNLRNSVVGFNDLTFVDFSSDKFPAIARAVCEQSLHRPASGEVAKFQCSKCLRAFPCRSALDAHETDCGTINSQIRTTDDSQSRRDDFFAGLDLQNKAALTEAKEGKDLADIQSIISVTSGPILQNFPRSDASTPENNIKFNPSVSSSGSSGTYSSEYHEEEAQDAFAAEFRKMKLKGEFPCRLCSAIFPNLRALKGHNRAHMGVGPGVPYPCNMCPYTSTDKATLVRHLRSHNGDRPYECSLCNYAFTTKANCERHVRNRHGKLTREDIKSVLIYHPNEDSTNENVERSSPRVLKDEVRKSLVYPSERDDLQHQTQMHYPPVPMEVRGEIRIIEEAKLHNSTMSMHNSNHFEKNDTFSRPGQPMELIQRNAEEGKPGQDAKSDYSKLDDDLESRSSEGSVSLVSDTKSESHQRIQASPMNLKKGLNLPENAGEDGPLDLSMDVLDLSKKSKGKEDSDFSASHEQFGKNQKDLYNATSQLLLTEALLKAGQGSSQPTSLEALYANAIYRNFSTFPAGVGGILPPYVFNPHVFGQDFSMKDRLQKELVRGLQLTSGGTLVESSIGGAAFTAFSQGRDMNSQSTTEQNEYAKLISAKMANKGLSNRDKPDNLPSSNSVKMVIKNGVLMPKQKQRRYRTERPFTCEHCSARFTLRSNMERHIKQQHPQHWSQRPRGGHSTRGRPPSSHPTLLQNLGQPASQVTQSYTNILPKVEQPVNSELTKHSISDQVKYAILAQQLKANKVEENDSEEELVIDEDPQEKESQESQNQKEKSLLRGQLEGTESTKEAAVKEEAKEPPKEVSQETNAESEKKEDTDTEETKSTESEKPTETEKTTDESPSRVFKTEPVEVKSEKMEDGTTDLASVSELLDNASQQYQQFQPQYLSDEEGLVASNSDCNNSGSDEKSDSVNSSNSVNTSAKKKKKKKKKKKKKSAYSMAPNRVICPYCERPFPWTSSLRRHILTHTGQKPYQCVHCSLLFTTKSNCDRHLLRKHKANPNKMRRVRNSSSPDSQAVSNNNNSFSMRNVPERPYKCNQCPSSTFSTLGNLKKHRSTKHARKIKSRSDTPSSEPQNSPQECSKQNNEQSDYDSQSSSVSEGMETSSMPGLPKSNSNTSPSTNDTPRSRRPSPRSSPGPSDVPFKCHLCDCGFAERQDCLEHIKVNHKRSYEMLVAKGALDMDIDTVEDQQQPPPQHHASDGEEKRGRFPDYSNRKVVCAFCMRRFWSAEDLRRHMRTHTGERPFSCDICCRRFTLKHSMLRHRKKHESIDSTMYVGTSGDEENSPTQPPTITPRSQQQPPILVAANSGNSRIQDRISLPTVAPVATGDAAPSGLMRFNPYEKLTTLTGKLASIPQNVNPDASESTDNDLISNLLGIRDKSFIDRVLQASADDAAKLLGVKRSHE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00625690;
90% Identity
iTF_01424585;
80% Identity
-