Elac022563.1
Basic Information
- Insect
- Eudonia lacustrata
- Gene Symbol
- pax6a
- Assembly
- GCA_947562085.1
- Location
- OX387322.1:13157195-13217916[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 6 2.3e-31 6.5e-28 98.0 0.3 1 59 47 105 47 112 0.95 2 6 1.1e-09 3.1e-06 28.0 0.0 34 57 174 197 158 215 0.87 3 6 7.8e-10 2.1e-06 28.5 0.1 16 54 288 326 275 337 0.91 4 6 2.4e-07 0.00066 20.5 0.0 30 69 345 385 333 398 0.82 5 6 3.5e-32 9.7e-29 100.7 0.1 45 118 396 468 377 473 0.88 6 6 0.058 1.6e+02 3.1 0.0 107 125 513 530 506 530 0.78
Sequence Information
- Coding Sequence
- ATGCACATGCAGACCAGCCTCCACAGGCTCCACAAGTGTGTTAGTGATCTAGTTCCGTGCGCGAACTCTACCGATGACGATGAGCTGATGCACAGCGCCGCAATGGGTGGGGGCGCCTTATTCGGGTGCTCCTCAGCGGGCCACAGCGGCATCAACCAGTTGGGGGGCGTCTACGTAAACGGGAGGCCGCTGCCGGACTCCACGCGGCAAAAAATCGTGGAGCTGGCGCACTCTGGCGCGCGGCCCTGCGACATCAGCCGAATCCTGCAGGTCTCCAACGGATGCGTGTCCAAGATACTCGGCAGGTCAGTCGCTGCTCAGAGCTATTGCTTCTCGGGGCATGATACCAGCTTGGCAGCACTCAGGTGCAAAACTCTGCAGGACGGTTGCTTGCCCAAGAGAGCTCTCAAAGAAGTCGGTGTCCAGGCTATTTACCAGGTTTGTGGGCGTCTATGTGACGGAGAGGCCGCAGCCAGACTCCACGCGGCAGAAGATCGTGGAGCTAGGGCACTCGGGCGCGTGTGGCCCTGTGACATCAGCCGCATCCTGCAGGTCTCCAACGGATGCGTGTCCAAGATACTCGGCAAGTCAGTCGCTGCTCAGAGATATCAATCTTTGGGTCTCTACCAGCTCGGCAGCAATCAGGTGCAAAGCTCTGTGATATCAGCCGCATCCTGCAGGTCTCCAACGAATGCGTGTCCAAGATACTCGGCAGGTCTCCAACAAATGCGTGTTCTAGATTCTCGGCAGGTCAGTCGCTCCTTAGAGGCGTTGCTTCTCGGGGCACTATACCAGCTTGGCAGCACTCAGGCGCAAAACTCTGCTGGACGGCTGCGTGCCCAAGGTATTCGGCAGATCAGGACGCCGCTGCTGGACCCCACGCGGAAGCAGATCATGGAGCTGGCGCTTTCGGATGCACGGCTCTGCCACATCAGCCGCATCTTGCAGGTCTCCAACAGATGCATGTCCGAGATCTCGGCTGGTCAGTCGCTGCTCAAAGCTATTGCGTCTTGGGGCACGATACCAGCTTGGAAGCATTCAGGAACGAAGTTCTATGACGTCAGCCGCATCCTGGAGGTCTCCAACGGTTGCATGTCCAAGATGCTCGGCAGGTCGTTGCAGCATAGTGCCCTTACACATCAGGGCACTATCGGCTTGGCAGCACTTAGGCGCGACAATATGCAGGTCCCCAAAAATGGGGTGCCCAATGTTCGCAGATATTACGAGACTGGGTCTATCAAGCCCCGAGCCATCGGGGGGTCGAAGCCGCGAGTAGCCACCACGCCGGTGGTGCAGAAGATAGCCGACTATAAGCGAGAGTGCCCCTCGATCTTCGCGTGGGAGATCAGAGACCGCCTCCTCAGCGAAAACGTGTGCAATAACGACAATATCCCTAGTACCCAATACACCGTACTCGTAGAACAAGAGTACGACGAACCGGTTCACACGCGCTCTATACCAGGTACAGACATGTACCTGGGCGTTTCTTTCCACCACCACGACCCGGTCAACCCGCACCACGCACAAGTGCGTGATGCCGTTCCCTCTAGAAAACCTCCGACGGTATCATCAATAAACCGGGTGCTAAGGAACCTCGCGTCCCAAAAAGAGCAGGCGGCATCAGCTCAGAACGACAGCGTCTACGAGAAGCTGAGGATGTTCAACGGCCAGGCTGCCACTGGCTGGTGGTATCCAGGACTGCCAACCGCACCAGCAGCGCCCGCCATACCAGCTCCCTTACCTCCCCAGCTCAACAGGCCGAGCAGTGAAGAGCATAAAAGAGATCCCCTCCAGTCAGAAGCGGGGTCAGACGGGAACAGTGAGCACGCATCATCAGGCGACGAGGACTCGCAGATGAGGCTACGGCTCAAGCGCAAGCTGCAGCGGAACCGCACCAGCTTCACCAACGACCAGATCGACAGCCTGGAGAAAGAGTTCGAGCGCACGCACTACCCGGACGTATTCGCGCGAGAAAGGCTCGCGGAAAAGATCGGATTGCCTGAGGCACGTATCCAGGTCTGGTTCTCCAACCGGAGGGCAAAATGGCGGCGAGAGGAGAAGCTCCGCAGCCAAAGGAGGGACGCGCCAGCGGCTTCGCCCCCCGCGCCGCCCGCGCCCCGCCTGCCCCTCAATGGAGGCTTCAACTCCATGTACAGTCCTATACCGCAGCCAATTGCCACCATGAGCGACTCGTATAGCTCAATGCCGGGCGGGCTATCGTCGTCGTGCCTGCAGCAGCGGGACGGCGGCTACCCCTACATGTTCGGTGACGTGCTCGGCGGCGGCGGGTACTCGCGCGCGCCCGCCGCGCACCAGCAGCACGCAGCCTACTCGCAGCCGCAGACCGCCGCGAGCACAGGTAATCGCAGCCGCAGACCGCCGCGAGCACAGGTGAGCGTGACAGCCAATCTGTACTGGCTAATCAGTTAG
- Protein Sequence
- MHMQTSLHRLHKCVSDLVPCANSTDDDELMHSAAMGGGALFGCSSAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRSVAAQSYCFSGHDTSLAALRCKTLQDGCLPKRALKEVGVQAIYQVCGRLCDGEAAARLHAAEDRGARALGRVWPCDISRILQVSNGCVSKILGKSVAAQRYQSLGLYQLGSNQVQSSVISAASCRSPTNACPRYSAGLQQMRVLDSRQVSRSLEALLLGALYQLGSTQAQNSAGRLRAQGIRQIRTPLLDPTRKQIMELALSDARLCHISRILQVSNRCMSEISAGQSLLKAIASWGTIPAWKHSGTKFYDVSRILEVSNGCMSKMLGRSLQHSALTHQGTIGLAALRRDNMQVPKNGVPNVRRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSENVCNNDNIPSTQYTVLVEQEYDEPVHTRSIPGTDMYLGVSFHHHDPVNPHHAQVRDAVPSRKPPTVSSINRVLRNLASQKEQAASAQNDSVYEKLRMFNGQAATGWWYPGLPTAPAAPAIPAPLPPQLNRPSSEEHKRDPLQSEAGSDGNSEHASSGDEDSQMRLRLKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRSQRRDAPAASPPAPPAPRLPLNGGFNSMYSPIPQPIATMSDSYSSMPGGLSSSCLQQRDGGYPYMFGDVLGGGGYSRAPAAHQQHAAYSQPQTAASTGNRSRRPPRAQVSVTANLYWLIS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00681503;
- 90% Identity
- iTF_00681503;
- 80% Identity
- iTF_00681503;