Basic Information

Gene Symbol
e2f7
Assembly
GCA_947562085.1
Location
OX387341.1:17645157-17646897[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 1.5e-22 2.5e-18 66.4 0.0 1 65 64 130 64 130 0.94
2 4 0.96 1.6e+04 -3.4 0.0 11 28 136 152 135 154 0.64
3 4 6.2e-17 1e-12 48.4 0.0 1 61 165 246 165 256 0.90
4 4 0.58 9.5e+03 -2.7 0.0 21 34 294 307 284 315 0.58

Sequence Information

Coding Sequence
ATGTATGAAAATGACAACATTACCTGCACCCCGAAGCGTTGCGCACTCACAGAACTAACGAATGCATCGAACAATGTTTCTCCTACTGCCAACCTCAAACTATTGACTAGTGTCGCGTTGCAAGAGAACGATCTCGTAAACCACAATGCGTTGCAATACCCGACGCCGCCGCCGAGCGCTGTTCATCGCAAAGAAAAATCCTTGCAGATATTATGCGACAGATTCCTTGAACTGTATCCTCTTCATGGAAAGAGTGCAGTTGAAATTCAATTAGATTGTACTGCAGCACGTTTAGGAGTAGAGAAGAGGCGAATGTATGACATTATAAATATACTAGAAGCAATGCAATGTGCCGTCCATAAGAGAAAAAATACCTATCTGTGGTATGGAGGATCAAGGCTAAATTCTTTCTTAAAGATGCTGAAGAAAGAAGGGGAGAATCTTAAGCTGTCTGATGCATTACGTGGCAAAGCTCCTAAGCCACCTGCTCCTAAACATAAGACTCTTGGAGTGATGGCCCAAAGGTTTCTTATGCTGTTCTTAGTGGAGCCACCGAACACTCTTATAAATCTGGAGATGGCAGTGCGGGTGCTGATCGACACATCTAACAAGAACAGAACAGCACTGTCGCCTGAGCAGCAGGATCGGCAACACAAATCCAAAGTCAGGAGGCTCTATGACATTGCTAATGTATTTATTTCTGTTGGTCTCATTGAAAAGGTATCTGGAAACTCTATATTGAAAAAGCCAGTCTTCAAGTATGCAGGACCTTTTAAAATTAAAAAGTCTGATGAGGTTTTTGACACACCTCCAATCACACCATTGACCGTGTTTGGGCAACGGACACCATGCCATGTCTTTGCCAGCAAGTCCAAACGAAAATTGGAGTTCACAACTTCTAATGTCTGCAAGCAACTAAAATTTGGCATTAACACACAAATAAATGCACCATCGCACAAGTGGAATGACATTTTGCTTGTTGCAAACATGGAATTGACTAAAATTAATAATGGCAAAATGTTGTGA
Protein Sequence
MYENDNITCTPKRCALTELTNASNNVSPTANLKLLTSVALQENDLVNHNALQYPTPPPSAVHRKEKSLQILCDRFLELYPLHGKSAVEIQLDCTAARLGVEKRRMYDIINILEAMQCAVHKRKNTYLWYGGSRLNSFLKMLKKEGENLKLSDALRGKAPKPPAPKHKTLGVMAQRFLMLFLVEPPNTLINLEMAVRVLIDTSNKNRTALSPEQQDRQHKSKVRRLYDIANVFISVGLIEKVSGNSILKKPVFKYAGPFKIKKSDEVFDTPPITPLTVFGQRTPCHVFASKSKRKLEFTTSNVCKQLKFGINTQINAPSHKWNDILLVANMELTKINNGKML

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01020016;
80% Identity
-