Basic Information

Gene Symbol
foxn3
Assembly
GCA_947034915.1
Location
CAMQQJ010000423.1:91948-100541[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 3.9e-30 7.1e-27 94.6 0.1 1 66 772 836 772 840 0.96
2 7 5.3e-15 9.7e-12 46.1 0.4 34 66 840 871 838 875 0.92
3 7 5.3e-15 9.8e-12 46.1 0.4 34 66 875 906 873 910 0.92
4 7 5e-15 9.2e-12 46.2 0.4 34 66 910 941 908 946 0.91
5 7 5.3e-15 9.7e-12 46.1 0.4 34 66 945 976 943 980 0.92
6 7 8.6e-15 1.6e-11 45.4 0.3 34 66 980 1011 978 1015 0.91
7 7 1.7e-19 3.1e-16 60.5 0.0 34 85 1015 1064 1013 1067 0.91

Sequence Information

Coding Sequence
atggattggaatgtaatgatCCCCAGGTGGAGATCGTCTATAATGAATGCGACCACGTACCCAGGTGCAGATTGTGGAAGCGACCATCAACTACTGGTTGCAACGATGCGATTACGACTTAAAAGAGTTATAAAGTCAAAACCGACTCCAAAGATACACAAAATGGATATTGTCGCATACGAAAACGAAATACAACAGCAACTATCGGAGATACCACGTGAGGACATCTTGGACAGCAATGCTTTTTGGAACACACTGAGAGACACTATTGTTCAAACAGCGAAAAAGTATGCCCTAGCGAAACCTACCATGAAAAGTCATATCTCAGAGGAAACAGCAAAAGTCATAAAAGAACGCCGGGATTTGAAGCAAGGAGGGCTGTCCAGTCCAGATCAGTTCGAGCGATACTCCCAACTAAGCGCCGAGGTTCAGCGGAAATGCAGGCAAGACTACAATGCTTACATCAACAACATCTGTGATGACCTTGAACAGCATGCCTTGAAAAACGAGACGAAAGACCTCTACCAGAAGTTAAAGCTATTAACCAGAGCTAGGCCGACTCAAACTTGTGCCATCAACGATGGAGACGGCCAACTTCTCACGGAAACGGATCAGGTGCTAGAACGCTGGAGGAAGTACTGCGCGTCACTCTACGACTGTACAGAAGATGCCACCTCAACATATTTATGGTCCGCTgacgaacctaacctacttccatcAGAGGTTGGGCAAGCCATTGACGCCCTGAAGAATGGTAAATCACCAGGTAAAGACGGCGTACCAGGAGAACTTCTCAAAAGACTCGGTGAAACAGGCTTATCAGTAATGACCAAGTTATGCAATCTCGTGTGGGAGTCAGGTGTGTGGCCCGAGGAGTGGAGAGAGTCATTATTTATCCCAATTCATAAGAAAGGCTCGACAAAAGACTGTGGCAACTACCGGACTATTGCACTAGTCCCGCATGCGAGTAAAATTCTTCTTCACATAATAAACCAGCGACTGAAGTACTTTCTTAGTAGACAAGTTCCTGAAGAGCAAGCGGGGTTCGTGAAGGGGAAAGGCACTCGAGAACAAATGCTGAACATCCGCCAGATTATTGAAAAAAGTCGAGAGTTCAATAACCCAGTTGTTCTGTGCTTCATCGACTATAcaaaggcatttgattgcgtacACTGGGATAAGCTGTGGTCCGTTCTGGAAGAGATGGGTGCACCAAGACATCTTATAGGTTTAATTCGAAACTTGTATACCGCCAACAGAAGCTTCATAAGAATTGGGTCAGAATGTTCCACATTGTTTCAGACCAAAAGAGGCGTACGACAGGGATGCATATTATCTCCTATGTTGTTTAACATATATGGCGAGTACATAATCCGCAAAACCCTTGAAGGCTGGAACAAAGGGTTTGCTGTTGGTGGGAAGAGAATAAGTAACCTGAGATACGCCGATGACACTGTACTTCTGGCATCTTCGATGTCTGACATGCAAGAACTTGTCAACAGGCTGGAGGTCGAGAGTGAGAGACAGGGTCTTGCAATTAACCGAAGCAAAACAAAGCTCATGGTGGTGGATCGGGCCGGCCTCCTGCCTGTAGCCTGTAAGATTCAAGGCATAGATATTGTGGATGACTTTGTGTATCTGGGGTCTAAAATATGCAAGGATGGTAGCTGTGTGCCCGAGATCAAGAGACGCATAGGAATGGCTAAGGATGCTATGACACGGCTCAAGAAAATCTGGCAAAATCGTGGAGTCTCTAAAAACACCAAAATACGTCTTGTGCGAGCCctagtatttcccattttcacCTATGGAGCTGAAACCTGGACAATCAAAAGCAGAGAGAAACAACGGATCGATGCCTTCGAGATGTGGTGTTGGAGGCGTATGCTGAGAATACCATGGACAGCTAGGCGCACGAACCAATCGATACTGTCGGAACTCAAAATTAACTTGCGATTGTCCACAATCTGCGAACAGCGCCTACTGAGTTACTTTGGCCAtataatgagaaggggagacGAAAGTTTGGAAAACGTGGCGTGCGGCGGCAACGCGGGCAACCTGCCGCCCGCCGACCACGACGACGACCTCACGAGCCTCAGCTGGCTGCAGGACAGGAACCTGCTCCGAGGGATAAATCTAACCAAAGGCGACGTCGAAGATGCAAAGATGATCGGCAGCCAAGTCATCATAAAGACGGAGTgctccacgccgccgccgctggcGCGCGTGGCCTCGCCGCCGCGCACGCCGTGCAAGGCGCCGCCGTCGCCCGGCCTCACGCAGCAACAAcagcaacaacaacaacaacacagCAAGCCGCCGTACTCGTTCTCGTGCCTGATCTTCATGGCGATCgaggcggcgccggcgcgcgcgctgccCGTCAAGGAGATCTACGCGTGGATCGTGCGCCACTTCCCCTACTTCCGCCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGCCACAACCTCTCCCTCAACAAGTGCTTCCACAAGGTCAGTGCCCGCCCGGTGCGCCACTTCCCCTACTTCCGCCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGCCACAACCTCTCCCTCAACAAGTGCTTCCACAAGGTCAGTGCCCGCCCGGTGCGCCACTTCCCCTACTTCCGCCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGCCACAACCTCTCCCTCAACAAGTGCTTCCACAAGGTCAGTGCCCGCCCGGTGCGCCACTTCCCCTACTTCCGCCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGCCACAACCTCTCCCTCAACAAGTGCTTCCACAAGGTCAGTGCCCGCCCGGTGCGCCACTTCCCCTACTTCCGCCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGCCACAACCTCTCCCTCAACAAGTGCTTCCACAAGGTCAGTGCCCGCCCGGTGCGCCGCTTCCCCTACTTCCGCCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGCCACAACCTCTCCCTCAACAAGTGCTTCCACAAGGTCAGTGCCCGCCCGGTGCGCCGCTTCCCCTACTTCCGCCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGCCACAACCTCTCCCTCAACAAGTGCTTCCACAAGGTGGCGGCGGCGCCGGGACTGGGCAAGGGCTCGCTGTGGACGGTAGACCCGCAGCACCGCTCCACTCTTTTGCAGGCGTTCGGGCGGCAGCCGATCCCGGCCATCTCGGCGTGCGGCTCCCCGCCTgtcgccgccgcgccgccgccgacgccgaCCAAGAACTCGCCGGACCCGGCGCTGTTCCCGTTCCTGGCGCGGCGGCTGGGCGCGGCGCGGCCCGAGCCCGGCGCCGACGAGTACCTCGCCGCCGCCACCGTGCTCGCCATGAAGTACGGGCCCGCCGTCCTCGACCAGGTCCGCACCGACACCACACACACACCACACACCCGGCATGTTGGCGCGGCGACCGGCCGCGACTCCAATATTATACAGACtcgttttaataataggacGCTTTACATGCTTTGGCATTTTACAACTGAGACCTGA
Protein Sequence
MDWNVMIPRWRSSIMNATTYPGADCGSDHQLLVATMRLRLKRVIKSKPTPKIHKMDIVAYENEIQQQLSEIPREDILDSNAFWNTLRDTIVQTAKKYALAKPTMKSHISEETAKVIKERRDLKQGGLSSPDQFERYSQLSAEVQRKCRQDYNAYINNICDDLEQHALKNETKDLYQKLKLLTRARPTQTCAINDGDGQLLTETDQVLERWRKYCASLYDCTEDATSTYLWSADEPNLLPSEVGQAIDALKNGKSPGKDGVPGELLKRLGETGLSVMTKLCNLVWESGVWPEEWRESLFIPIHKKGSTKDCGNYRTIALVPHASKILLHIINQRLKYFLSRQVPEEQAGFVKGKGTREQMLNIRQIIEKSREFNNPVVLCFIDYTKAFDCVHWDKLWSVLEEMGAPRHLIGLIRNLYTANRSFIRIGSECSTLFQTKRGVRQGCILSPMLFNIYGEYIIRKTLEGWNKGFAVGGKRISNLRYADDTVLLASSMSDMQELVNRLEVESERQGLAINRSKTKLMVVDRAGLLPVACKIQGIDIVDDFVYLGSKICKDGSCVPEIKRRIGMAKDAMTRLKKIWQNRGVSKNTKIRLVRALVFPIFTYGAETWTIKSREKQRIDAFEMWCWRRMLRIPWTARRTNQSILSELKINLRLSTICEQRLLSYFGHIMRRGDESLENVACGGNAGNLPPADHDDDLTSLSWLQDRNLLRGINLTKGDVEDAKMIGSQVIIKTECSTPPPLARVASPPRTPCKAPPSPGLTQQQQQQQQQHSKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFRHAPQGWKNSVRHNLSLNKCFHKVSARPVRHFPYFRHAPQGWKNSVRHNLSLNKCFHKVSARPVRHFPYFRHAPQGWKNSVRHNLSLNKCFHKVSARPVRHFPYFRHAPQGWKNSVRHNLSLNKCFHKVSARPVRHFPYFRHAPQGWKNSVRHNLSLNKCFHKVSARPVRRFPYFRHAPQGWKNSVRHNLSLNKCFHKVSARPVRRFPYFRHAPQGWKNSVRHNLSLNKCFHKVAAAPGLGKGSLWTVDPQHRSTLLQAFGRQPIPAISACGSPPVAAAPPPTPTKNSPDPALFPFLARRLGAARPEPGADEYLAAATVLAMKYGPAVLDQVRTDTTHTPHTRHVGAATGRDSNIIQTRFNNRTLYMLWHFTTET

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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