Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 5.4e-06 0.15 13.8 0.4 13 44 26 57 15 60 0.85

2 5 0.0056 1.6e+02 4.1 0.0 21 44 62 85 58 89 0.87

3 5 0.01 2.9e+02 3.3 0.0 21 43 90 112 87 118 0.86

4 5 0.0091 2.6e+02 3.4 0.0 21 45 118 142 111 145 0.85

5 5 0.0027 77 5.1 0.0 22 45 147 170 143 175 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	5.4e-06	0.15	13.8	0.4	13	44	26	57	15	60	0.85
2	5	0.0056	1.6e+02	4.1	0.0	21	44	62	85	58	89	0.87
3	5	0.01	2.9e+02	3.3	0.0	21	43	90	112	87	118	0.86
4	5	0.0091	2.6e+02	3.4	0.0	21	45	118	142	111	145	0.85
5	5	0.0027	77	5.1	0.0	22	45	147	170	143	175	0.84

Coding Sequence: ATGCAATTACACTCGGAGGATAGGCCCTATAGGTGTGAGGTGTGTGATGACCGTTTCAAAACCCGCAATGCCTACGAAGGCCATCGTGTAACGCATAATCCTGAAAATCCCAACACCTGTGGAATATGTGGTAAGTCATATCGTCAAGCCCCATCCCTGCGAATTCACATGTTTTCCCATACGGGTGAAAAACcatataaatgtgaaatttgtGGCAAATGTTTAACACAAAAATCGGGCTACAAGAAACACATGTTAACACATACCGGGGAAAAACCATATCCTTGCGATCTGTGCGGGAAGGCATTCCGTATTTCCAGTAATATGTTGGCTCATCGTCGTAGCCATTTGGGTGAAAAGCCTTACGTGTGTCTAGAGTGTGGCAACTCCTTTGGTACTTCGGAGCAATTAAAACGCCATATGATGGTGCATTCCGATGATACACCTTTCTCTTGTGATATTTGCGGCAAACAATTTAAGCGACAGTCGGCCTTGAGAGCACATCTTCAAAGTCATGAGAATCATGTGACTGTCACGCATAAGAAAGTTGGAAAATCGAGTGTTGTAGAAATTATATGA
Protein Sequence: MQLHSEDRPYRCEVCDDRFKTRNAYEGHRVTHNPENPNTCGICGKSYRQAPSLRIHMFSHTGEKPYKCEICGKCLTQKSGYKKHMLTHTGEKPYPCDLCGKAFRISSNMLAHRRSHLGEKPYVCLECGNSFGTSEQLKRHMMVHSDDTPFSCDICGKQFKRQSALRAHLQSHENHVTVTHKKVGKSSVVEII

Sequence clustering based on sequence similarity using MMseqs2