Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0018 1.2 10.6 0.1 21 52 42 73 37 75 0.87

2 8 0.34 2.3e+02 3.3 0.0 22 51 71 100 66 101 0.82

3 8 0.068 46 5.5 0.1 21 46 98 123 95 125 0.91

4 8 0.14 98 4.5 0.0 22 45 127 150 124 156 0.90

5 8 5.1 3.5e+03 -0.5 0.0 27 52 160 185 152 186 0.77

6 8 0.011 7.5 8.1 0.2 23 52 184 213 180 215 0.86

7 8 0.72 4.9e+02 2.2 0.0 21 45 210 234 206 243 0.86

8 8 5.1 3.5e+03 -0.5 0.1 21 43 238 260 218 264 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0018	1.2	10.6	0.1	21	52	42	73	37	75	0.87
2	8	0.34	2.3e+02	3.3	0.0	22	51	71	100	66	101	0.82
3	8	0.068	46	5.5	0.1	21	46	98	123	95	125	0.91
4	8	0.14	98	4.5	0.0	22	45	127	150	124	156	0.90
5	8	5.1	3.5e+03	-0.5	0.0	27	52	160	185	152	186	0.77
6	8	0.011	7.5	8.1	0.2	23	52	184	213	180	215	0.86
7	8	0.72	4.9e+02	2.2	0.0	21	45	210	234	206	243	0.86
8	8	5.1	3.5e+03	-0.5	0.1	21	43	238	260	218	264	0.77

Coding Sequence: ATGAGCGACTCCTCGGAACCCGCTGGGAACCACGGGACGGGCCCAAGGGCGTACAGGTGCGTCGAGTGCGACAAAACTTTCAAGCGGAACAGCCACCTGTCGAGGCACATGAGGATCCACACGGGTGAGAAACCGTTCCGGTGCCCCCTGTGCGGCAAAGCGTTCTCGGCCTCCGGTAACATGAGGACGCACGTGAGGGTCCACACCCGCGACAAGCCCTACAGGTGCGTCGAGTGCGGCAAAACGTTTGCGGTTTCCACGAATCTGAAAGAGCACCTGAAGATTCACACGGGTGAGAAGCCGTACGCTTGCGCCGTGTGCGGGACAAGCTTCGTGCAGTACAACCAGTTGAAGACGCACCTCAGGATCCACACGGGCGAGAGACCGTACAAGTGCGGGGAGTGCCGCAAGGCGTTCAGGGATTCGGGTAGCTTGACGAGGCACGCGAAGGTTCACACGGGCGAGAAGCTTTACAGGTGCGCCGAGTGCGGCAAAAATTTTTCCACCTCGTCCAACTTGACGAAGCACATGTGGATCCACACCGGGACGAAGCCCTACAAGTGCGTGGAGTGCGAGGCGAGTTTCACCCAGTGCAGCAACCTGAGGAcgcacatgaggattcacacggGTGAGAAGCCATTCAAGTGCGCCCGGTGCGACAAAGCGTTCACGGTGTCGAGTAATTTGAAAGAGCACGCGAGGACCCACACGGGGGAGAAGCCGTTCGAGTGTGCCGAGTGCGGCAGGACGTTCTCGTCTGCTGGCAGCCTGAGGAAACACTCGGTGACCCACGGCGCCGGTGTGACGGCGGTGATGCGAGAGGCGTGGGACACTTGA
Protein Sequence: MSDSSEPAGNHGTGPRAYRCVECDKTFKRNSHLSRHMRIHTGEKPFRCPLCGKAFSASGNMRTHVRVHTRDKPYRCVECGKTFAVSTNLKEHLKIHTGEKPYACAVCGTSFVQYNQLKTHLRIHTGERPYKCGECRKAFRDSGSLTRHAKVHTGEKLYRCAECGKNFSTSSNLTKHMWIHTGTKPYKCVECEASFTQCSNLRTHMRIHTGEKPFKCARCDKAFTVSSNLKEHARTHTGEKPFECAECGRTFSSAGSLRKHSVTHGAGVTAVMREAWDT

Sequence clustering based on sequence similarity using MMseqs2