Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 2.6 1.7e+03 0.5 0.1 22 48 55 81 46 93 0.81

2 7 1.7 1.2e+03 1.0 0.1 21 45 110 134 102 137 0.88

3 7 0.075 51 5.4 0.1 21 51 138 168 134 170 0.86

4 7 0.35 2.4e+02 3.3 0.0 21 44 166 189 164 193 0.90

5 7 0.00037 0.25 12.8 0.0 21 52 194 225 191 227 0.89

6 7 0.034 23 6.5 0.0 22 51 223 252 220 254 0.87

7 7 0.57 3.8e+02 2.6 0.0 22 46 251 275 248 282 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	2.6	1.7e+03	0.5	0.1	22	48	55	81	46	93	0.81
2	7	1.7	1.2e+03	1.0	0.1	21	45	110	134	102	137	0.88
3	7	0.075	51	5.4	0.1	21	51	138	168	134	170	0.86
4	7	0.35	2.4e+02	3.3	0.0	21	44	166	189	164	193	0.90
5	7	0.00037	0.25	12.8	0.0	21	52	194	225	191	227	0.89
6	7	0.034	23	6.5	0.0	22	51	223	252	220	254	0.87
7	7	0.57	3.8e+02	2.6	0.0	22	46	251	275	248	282	0.85

Coding Sequence: atggatAACGCTGAAGAATGTGGAGGTGATTCCATCAACTCAAAATCTCCCAAACGCCACAAGAAGGGTCACAAGAGTAAAAGGCGTTACGACTGCGTCGAGTGCGAGAAGTCTTTTTCCGCGTTGAGTACTTTACGAAACCACATGACGACTCACAGCGGTAAAAAGCCGTACAAGTGTAGCGAGTGTGACAAATCATTCGCGGTGTCGACTAATTTAAAAACGCACACGAGGATTCACAcgggtgaaaaaccatacaaatgtgtggAATGTCACCAAAAGTTTTCGCATTTGAGcagtttaaaaattcacatgaggattcacactggcgaAAAACCTTACAAATGCTCCGAATGTTTAAAGACATTTGCAGTatcttgtaatttaattacacacatgaggattcacaccggTGAAAGGCCGTTCATATGTGTTGAATGTGACAAGACATTCTCACAgtcgaataatttaattacgcacatgagaattcacaccgGCGAAAAGCCGTACAAGTGTGCAGAGTGTGACGAAGCGTTCTTGCAATCTGGTAACCTCAGTAGTCACATGTGGATTCACAccggtgagaaaccatacaaatgtgacGTGTGCGGTAAAACGTTCACTCAGTCGTATACGCTGAGGAAACACCTGAGGATTCACGCTGGTGAAAAACCGTTCGTTTGCGCCGAATGCGACAAGACGTTCTCGcagtcaaataatttacttacccacatgagaattcacaccgGTGAAAAGCCGTACAAGTGCGTCGAGTGCGGCAGGACATTCTCACAGTCGAGTAAACTGACGAAacacatgagaactcacactggtgaaaaaccatacaaatgcaCTGGTTGTCACAAAGCGTATTCAACGTTAACTACCATAAAAaatcacatgaggattcacacagcTGAAAAGTTGTGCAATACCGTAAAACATTCGTACAGCCACGCACATTCAGAAGAAACACAATGA
Protein Sequence: MDNAEECGGDSINSKSPKRHKKGHKSKRRYDCVECEKSFSALSTLRNHMTTHSGKKPYKCSECDKSFAVSTNLKTHTRIHTGEKPYKCVECHQKFSHLSSLKIHMRIHTGEKPYKCSECLKTFAVSCNLITHMRIHTGERPFICVECDKTFSQSNNLITHMRIHTGEKPYKCAECDEAFLQSGNLSSHMWIHTGEKPYKCDVCGKTFTQSYTLRKHLRIHAGEKPFVCAECDKTFSQSNNLLTHMRIHTGEKPYKCVECGRTFSQSSKLTKHMRTHTGEKPYKCTGCHKAYSTLTTIKNHMRIHTAEKLCNTVKHSYSHAHSEETQ

Sequence clustering based on sequence similarity using MMseqs2