Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 5.5 3.7e+03 -0.6 0.1 23 44 9 30 5 38 0.72

2 8 0.17 1.2e+02 4.2 0.0 21 47 35 61 31 68 0.84

3 8 1.3 8.7e+02 1.4 0.2 21 41 63 83 59 90 0.76

4 8 0.055 38 5.8 0.0 14 46 83 116 77 119 0.81

5 8 0.077 52 5.4 0.2 21 52 119 150 115 165 0.89

6 8 0.0056 3.8 9.0 0.2 21 46 175 200 157 207 0.87

7 8 0.027 19 6.8 0.2 21 45 231 255 220 264 0.88

8 8 0.0078 5.3 8.5 0.1 21 48 287 313 276 317 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	5.5	3.7e+03	-0.6	0.1	23	44	9	30	5	38	0.72
2	8	0.17	1.2e+02	4.2	0.0	21	47	35	61	31	68	0.84
3	8	1.3	8.7e+02	1.4	0.2	21	41	63	83	59	90	0.76
4	8	0.055	38	5.8	0.0	14	46	83	116	77	119	0.81
5	8	0.077	52	5.4	0.2	21	52	119	150	115	165	0.89
6	8	0.0056	3.8	9.0	0.2	21	46	175	200	157	207	0.87
7	8	0.027	19	6.8	0.2	21	45	231	255	220	264	0.88
8	8	0.0078	5.3	8.5	0.1	21	48	287	313	276	317	0.87

Coding Sequence: ATGTTCAGCCCAGACACTGTTGCAAAACCGCATACGTGTTTTCAGTGTTTCAAATCCTTCAAAATTCGGAGTAAACTGATTgtgcacatgaggattcacacaggtgaaaaaccatacacgTGTGCCGAGTGTGGTAAAAATTTCCGAGTATCGGGGCAATTAACAAaccacatgaggactcacacagGCGAGAAACCGTACATATGTGCTGtgtgttttaaaatgttctcaGTTCCAAGTAAATTGAAAGTACACTCAAGGATTCACACGGGcgagaagccatacaaatgtgtcgagtgtgacgCTACATTTACTCAGTCTGGCCAGTTAGGAAACCACATGAGAATCCACTCTGGGGAGCAACCGTTCAGTTGTGTAGAGTGTGATGCATCGTACACGCATTATACTACCCTAAGAAATCACATGAGAATACACACTGGTGataaaccatttaaatgtgATCTGTGTGAAAGATCATTTGCACAGCCTGGTCTGCTAGCGATTCACATGAGGGTACATACTGGGGAAAAACCTTACACATGTGAAGTGTGTTTCAAAAGATTTTCTCAATCTAGCCCATTAGCAATACACATGAGGATACATTCCGGTGAAAGGCCATTTAATTGCCTTcagtgtaataaaacattttcgcTTTTAAGTACTTTAAAAGACCATttgaggattcacacaggtgaaaagccatacacaTGTGCCGCGTGCCAGAAATCATTCCGGGTATCAAGCCAGTTGACAAaccacatgaggactcacaccgGCGAGAGACCGTACAAATGCTTTGAGTGTTTGAAGTCATTTGCAGAATTAGGTTCCCTTAGAAAGCACATTCGGACCCATACTGGAGAAAAGCCTTACATATGTGTCATCTGCAAAAAGACATTCTCGCAATCTGGACAATTGGCTCAACATATCAAGGTCCATTTCATCAAcaccatttaa
Protein Sequence: MFSPDTVAKPHTCFQCFKSFKIRSKLIVHMRIHTGEKPYTCAECGKNFRVSGQLTNHMRTHTGEKPYICAVCFKMFSVPSKLKVHSRIHTGEKPYKCVECDATFTQSGQLGNHMRIHSGEQPFSCVECDASYTHYTTLRNHMRIHTGDKPFKCDLCERSFAQPGLLAIHMRVHTGEKPYTCEVCFKRFSQSSPLAIHMRIHSGERPFNCLQCNKTFSLLSTLKDHLRIHTGEKPYTCAACQKSFRVSSQLTNHMRTHTGERPYKCFECLKSFAELGSLRKHIRTHTGEKPYICVICKKTFSQSGQLAQHIKVHFINTI

Sequence clustering based on sequence similarity using MMseqs2