Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0072 4.9 8.7 0.1 21 44 34 57 29 61 0.90

2 8 0.0013 0.85 11.1 0.2 21 52 62 93 58 95 0.91

3 8 0.73 4.9e+02 2.2 0.0 23 46 92 115 86 117 0.88

4 8 7.1 4.8e+03 -0.9 0.0 26 52 123 149 115 150 0.81

5 8 0.74 5e+02 2.2 0.1 21 46 146 171 129 178 0.85

6 8 2.8 1.9e+03 0.3 0.2 21 45 174 198 166 201 0.85

7 8 0.00087 0.59 11.6 0.1 21 47 202 228 194 233 0.85

8 8 0.31 2.1e+02 3.4 0.1 21 43 230 252 228 259 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0072	4.9	8.7	0.1	21	44	34	57	29	61	0.90
2	8	0.0013	0.85	11.1	0.2	21	52	62	93	58	95	0.91
3	8	0.73	4.9e+02	2.2	0.0	23	46	92	115	86	117	0.88
4	8	7.1	4.8e+03	-0.9	0.0	26	52	123	149	115	150	0.81
5	8	0.74	5e+02	2.2	0.1	21	46	146	171	129	178	0.85
6	8	2.8	1.9e+03	0.3	0.2	21	45	174	198	166	201	0.85
7	8	0.00087	0.59	11.6	0.1	21	47	202	228	194	233	0.85
8	8	0.31	2.1e+02	3.4	0.1	21	43	230	252	228	259	0.90

Coding Sequence: ATGAGGGTTCATTCCGGTATAGAGCCGTACAAATGTCGCGAGTGTGGCGCAACATTCTCTCGATTGTCTGGGCTAGCGTGCCACAAGAAAATACACTCTGGTGAAAAACCCTACGTGTGTGCCGTTTGTCAGCAAGCATTTGTTCAATCTGGTAATCTTACGTCTCACATGAGGACccatactggtgaaaaaccatacaaatgtgcagTGTGCGGCAAATGtttttcagtttcaaataatttaagatcTCACATTAGAACCCACACAGGCgcaaagccatacaaatgtctTGAATGCGACGCGACGTTCTCCAAATCGTCTCAACTGAAATATCATCTAAGGATTCACTCGGGCGAAGACATACACAAATGCTCCGAGTGTGATGCCAGGTTCCCACACTCGTCCTTTTTGACGAACCACATGAGACTTCACACCGCTGAAAAACCGTTCAAATGCGCTGACTGCGACGCGACGTTCACCAGATCATCTGCGTTGACCTATCACAAGAGAATCCActctggtgaaaaaccatataaGTGTAACGAGTGTGGTAAGTGTTTTACGCGTTCAAATCTTTTGAAATGTCACCTCAGGACCCACACGGGAGAAAAGCCGTACAACTGCCCTGAATGCGACGCAAAGTTCTCAGACTCGTCCAACTTGAGGATTCACAAAAGAATTCACACTGGCGAGAAGCCGTACGGATGTCTGGAGTGTGCTGCAAGATTCTCGCAATCGTCAGCACTAAAACATCACTCGAGAACTCACGGCGTTAAAAATGTATCCCAATGTTCTCGACACCGACTAATCGCACGGCAATTCCCAGTGGCGTAA
Protein Sequence: MRVHSGIEPYKCRECGATFSRLSGLACHKKIHSGEKPYVCAVCQQAFVQSGNLTSHMRTHTGEKPYKCAVCGKCFSVSNNLRSHIRTHTGAKPYKCLECDATFSKSSQLKYHLRIHSGEDIHKCSECDARFPHSSFLTNHMRLHTAEKPFKCADCDATFTRSSALTYHKRIHSGEKPYKCNECGKCFTRSNLLKCHLRTHTGEKPYNCPECDAKFSDSSNLRIHKRIHTGEKPYGCLECAARFSQSSALKHHSRTHGVKNVSQCSRHRLIARQFPVA

Sequence clustering based on sequence similarity using MMseqs2