Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.17 1.2e+02 4.3 0.0 21 52 6 37 2 39 0.87

2 9 0.61 4.2e+02 2.5 0.0 21 51 34 64 30 66 0.86

3 9 0.81 5.5e+02 2.1 0.1 21 46 62 87 58 92 0.90

4 9 2.6 1.8e+03 0.5 0.0 25 44 94 113 86 116 0.85

5 9 0.02 14 7.2 0.0 18 52 114 149 108 151 0.82

6 9 1.6 1.1e+03 1.1 0.0 22 44 147 169 144 174 0.89

7 9 0.062 42 5.7 0.0 21 49 202 230 195 233 0.87

8 9 0.0025 1.7 10.2 0.2 21 51 230 260 226 262 0.86

9 9 1.5 1e+03 1.2 0.0 22 50 284 312 278 314 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.17	1.2e+02	4.3	0.0	21	52	6	37	2	39	0.87
2	9	0.61	4.2e+02	2.5	0.0	21	51	34	64	30	66	0.86
3	9	0.81	5.5e+02	2.1	0.1	21	46	62	87	58	92	0.90
4	9	2.6	1.8e+03	0.5	0.0	25	44	94	113	86	116	0.85
5	9	0.02	14	7.2	0.0	18	52	114	149	108	151	0.82
6	9	1.6	1.1e+03	1.1	0.0	22	44	147	169	144	174	0.89
7	9	0.062	42	5.7	0.0	21	49	202	230	195	233	0.87
8	9	0.0025	1.7	10.2	0.2	21	51	230	260	226	262	0.86
9	9	1.5	1e+03	1.2	0.0	22	50	284	312	278	314	0.85

Coding Sequence: atgaggactcacacagGTGAGAAGCCATACAAGTGTAccgagtgtgataaaacattctcccAATCAGGACACTTAACAAGTCActtgaggattcacactggtgagaaaccattcaGATGTGTGGAGTGTGATAAGACATTCTCACAATCTACGAGCTTAACAagccacatgaggattcacactggtgagaagcctTACAGATGTGTCCAATGTGTTAAGACATTCTCAACTTCTACAGAATTAACAAAACACTTGAgggttcacactggtgagaagctattaaaatgtatagtttgtgataaaacattctcaactTCCTCGGACTTAAGAAAACACACAAGgtctcacactggtgaaaaaccttacaaatgtgttgagtgtgatacaaGTTTCGCACAATCCTCAGGCTTTAGAaagcacatgaggattcacacaggtgaaaaaccatacaaatgcaTTGATTGTGACAAAACATTCTCAGAATCCTCTTACTTAAAACGTCATGTgtggattcacactggtgataaaTCATTCAAATGTGTAGCATGTGATAAAGCATTTACAACTTCCACACACTTAACAaatcacatgaggattcacactggtgagaaaccatacaaatgtgttgagtgttatAAATCATTCTCAACTTCCACACATTTAACAAACCActtgaggattcacactggtgagaaaccatacaaatgtgttgtgtGTGATAGATCATTTTCAGATTCTTCAAGCTTAAGAAGACACTTGAGGACTCACTCTAGTaagaaaccatataaatgtgatGAAACTTTCTCAGAGTTTTCAAGCTTAACAAGTCACAAGAGGATGTACACTGGTGATAAACCATACATATGTAttgagtgtgataaatcattctcaCAATCTTCCAGATTAACAAGCCACATGAAGATACACATTTTTGAGGGACCATAA
Protein Sequence: MRTHTGEKPYKCTECDKTFSQSGHLTSHLRIHTGEKPFRCVECDKTFSQSTSLTSHMRIHTGEKPYRCVQCVKTFSTSTELTKHLRVHTGEKLLKCIVCDKTFSTSSDLRKHTRSHTGEKPYKCVECDTSFAQSSGFRKHMRIHTGEKPYKCIDCDKTFSESSYLKRHVWIHTGDKSFKCVACDKAFTTSTHLTNHMRIHTGEKPYKCVECYKSFSTSTHLTNHLRIHTGEKPYKCVVCDRSFSDSSSLRRHLRTHSSKKPYKCDETFSEFSSLTSHKRMYTGDKPYICIECDKSFSQSSRLTSHMKIHIFEGP

Sequence clustering based on sequence similarity using MMseqs2