Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.65 4.4e+02 2.4 0.0 21 52 6 37 3 38 0.86

2 9 0.094 64 5.1 0.1 22 47 35 60 30 66 0.84

3 9 0.51 3.5e+02 2.7 0.1 21 46 62 87 58 94 0.85

4 9 6.2 4.2e+03 -0.7 0.1 22 48 91 117 88 123 0.63

5 9 0.52 3.5e+02 2.7 0.0 14 45 139 170 132 173 0.80

6 9 0.0019 1.3 10.5 0.1 21 45 174 198 163 205 0.86

7 9 0.34 2.3e+02 3.3 0.0 21 51 202 232 197 234 0.84

8 9 0.96 6.5e+02 1.9 0.0 21 46 230 255 227 257 0.89

9 9 0.00077 0.52 11.8 0.2 21 46 258 283 256 287 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.65	4.4e+02	2.4	0.0	21	52	6	37	3	38	0.86
2	9	0.094	64	5.1	0.1	22	47	35	60	30	66	0.84
3	9	0.51	3.5e+02	2.7	0.1	21	46	62	87	58	94	0.85
4	9	6.2	4.2e+03	-0.7	0.1	22	48	91	117	88	123	0.63
5	9	0.52	3.5e+02	2.7	0.0	14	45	139	170	132	173	0.80
6	9	0.0019	1.3	10.5	0.1	21	45	174	198	163	205	0.86
7	9	0.34	2.3e+02	3.3	0.0	21	51	202	232	197	234	0.84
8	9	0.96	6.5e+02	1.9	0.0	21	46	230	255	227	257	0.89
9	9	0.00077	0.52	11.8	0.2	21	46	258	283	256	287	0.91

Coding Sequence: ATGAGagttcacactggtgagaagccatacgTATGTTCTGGGTGCGATGCAAGGTTCTCCGACTCTTCCGCGTTAACGatgcacatgaggattcacactggccaaaaaccatacaaatgtgccgAGTGTGACGAAGCATTTTGTCAGTCATCTAATCTGACAAGTCACTTAAGAACACACAGCGGCGAaaagccattcaaatgtgttgagtgtggagCAGCGTTCTCGCGTTCATCTTCCTTAACGAATCACATGAGAATACACACTGGTGAAaggccatacaaatgtgttgagtgtgatgtACAGTTTGCGATATTAGCCAGTTTAAAAAGGCACATGAGagttcacactggtgaaaagccatataGATGTGTTGATTGTGATATAAAATTCTCTGATTCAGGCAGTTTGAAAAAACACAGGAGAATCCATTccggtgaaaagccatacaaatgtacagagtgttttataaagttttcgTTATCAGGTAGTTTAAAATCTCACATGAGagttcacactggtgaaaaaccgtATAAATGTCCGCAGTGTAATGATGTATTTTCTCAATCATCTCATCTAACAACTCACATACGAACTCATAGTGGTGAGAGGCCGTACAAATGTGCTGCATGTGATTCAGGTTTCTCAAACTCGTCCACCTTAAAAaatcacatgaggattcacacaggggaaaagccatacaaatgctCCGAGTGTGATGCAGAGTTTTCTGAATTAGGTAGTTTAAAAAGACATATGaagattcacactggtgaaaagccacaCACGTGTCCCGAGTGTGAGACACGGTTCTCTGAATCAAGTAGCTTAAAACGGCATATGAGGGTTCACAATGGTAAAAATTGA
Protein Sequence: MRVHTGEKPYVCSGCDARFSDSSALTMHMRIHTGQKPYKCAECDEAFCQSSNLTSHLRTHSGEKPFKCVECGAAFSRSSSLTNHMRIHTGERPYKCVECDVQFAILASLKRHMRVHTGEKPYRCVDCDIKFSDSGSLKKHRRIHSGEKPYKCTECFIKFSLSGSLKSHMRVHTGEKPYKCPQCNDVFSQSSHLTTHIRTHSGERPYKCAACDSGFSNSSTLKNHMRIHTGEKPYKCSECDAEFSELGSLKRHMKIHTGEKPHTCPECETRFSESSSLKRHMRVHNGKN

Sequence clustering based on sequence similarity using MMseqs2