Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 2.7 1.8e+03 0.4 0.1 21 47 6 32 2 39 0.83

2 10 0.059 40 5.7 0.0 17 47 57 88 47 95 0.81

3 10 1.1 7.3e+02 1.7 0.0 21 48 90 117 86 121 0.84

4 10 0.0012 0.81 11.2 0.1 21 52 118 149 105 150 0.88

5 10 0.028 19 6.8 0.0 24 52 149 177 146 179 0.86

6 10 0.82 5.5e+02 2.1 0.0 22 44 175 197 172 201 0.90

7 10 0.036 25 6.4 0.1 21 45 202 226 197 232 0.88

8 10 0.0013 0.9 11.0 0.2 22 44 231 253 226 257 0.88

9 10 0.26 1.8e+02 3.7 0.0 21 46 258 283 254 291 0.84

10 10 1.6 1.1e+03 1.1 0.0 21 44 286 309 282 313 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	2.7	1.8e+03	0.4	0.1	21	47	6	32	2	39	0.83
2	10	0.059	40	5.7	0.0	17	47	57	88	47	95	0.81
3	10	1.1	7.3e+02	1.7	0.0	21	48	90	117	86	121	0.84
4	10	0.0012	0.81	11.2	0.1	21	52	118	149	105	150	0.88
5	10	0.028	19	6.8	0.0	24	52	149	177	146	179	0.86
6	10	0.82	5.5e+02	2.1	0.0	22	44	175	197	172	201	0.90
7	10	0.036	25	6.4	0.1	21	45	202	226	197	232	0.88
8	10	0.0013	0.9	11.0	0.2	22	44	231	253	226	257	0.88
9	10	0.26	1.8e+02	3.7	0.0	21	46	258	283	254	291	0.84
10	10	1.6	1.1e+03	1.1	0.0	21	44	286	309	282	313	0.88

Coding Sequence: ATGAGGAATCACACTGGTGAAAGACCTTACAAATGTGTTGCATGTGGTAAACAATTTCACCGATCCTCGCACTTAACAAGTCActtgaggactcacactggtgagaaaccatacaaatgtgtagagtgtggTAAACAATTCCATCGGTCCTCACACTTAACCAGTCACTctaggactcacactggtgagaaaccatacaaatgtgttgagtgtggtaAAGAATTCTCAGATTCTTCAGCATTAAGAAGGCACATGAgtactcacactggtgagaagccatacaaatgtgtagagtgtgagGTAGCATTCACTCACTCTACAAGCTTAACAaaacacatgagaattcacactggtgaaaaaccatacaaatgtgtagagtgtgagGTAGTATTCACACTTTCTGCAAACTTAAGaaaacacatgaggattcacactggtgtaaaaccatacaaatgtattgAGTGTGGTAAAGTATTCTCAGATTCCTCATTATTAAGAAGGCAcctgaggattcacactggggagaagccatacaaatgtgttgaatgtgataaaaatttctCACAATTCAGAGACTTAAAAAATCatatgaggactcacactggtgaaagaCCATATAAATGTTTTGAGTGTGGTAAGGAATTCTCTGATTCCTGTAACTTAAGAAGGCACATGAGGAcgcacactggtgaaaagcaaTACACATGTGTTGAGTGTAAAAATGTATTCTCACAATTGTCAAATTTAAGGAggcacatgaggactcacactggtgagaatccatacaaatgtgttgagtgtggtaAAGGATTCTCAGATTCCTGTAACCTAACTAggcacatgaggactcacactggtgagaagccatataaatgtgttgaatgtgttaAAGAATTTTCAGATTCCTCAACTTTAAGAAATCACATGAGGACACACACTGGTGAGAAGACTTaa
Protein Sequence: MRNHTGERPYKCVACGKQFHRSSHLTSHLRTHTGEKPYKCVECGKQFHRSSHLTSHSRTHTGEKPYKCVECGKEFSDSSALRRHMSTHTGEKPYKCVECEVAFTHSTSLTKHMRIHTGEKPYKCVECEVVFTLSANLRKHMRIHTGVKPYKCIECGKVFSDSSLLRRHLRIHTGEKPYKCVECDKNFSQFRDLKNHMRTHTGERPYKCFECGKEFSDSCNLRRHMRTHTGEKQYTCVECKNVFSQLSNLRRHMRTHTGENPYKCVECGKGFSDSCNLTRHMRTHTGEKPYKCVECVKEFSDSSTLRNHMRTHTGEKT

Sequence clustering based on sequence similarity using MMseqs2