Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 5 3.4e+03 -0.5 0.0 27 44 11 28 3 32 0.82

2 9 0.0015 1 10.8 0.1 21 51 33 63 27 66 0.86

3 9 5.2 3.5e+03 -0.5 0.0 22 46 62 86 59 92 0.85

4 9 1.3 8.8e+02 1.4 0.0 26 48 94 116 85 121 0.79

5 9 1.8 1.2e+03 1.0 0.0 21 52 117 148 113 149 0.87

6 9 0.018 12 7.4 0.2 21 48 145 172 139 176 0.86

7 9 0.11 72 4.9 0.0 22 45 174 197 171 200 0.87

8 9 0.0061 4.1 8.9 0.0 21 44 201 224 197 228 0.90

9 9 0.0087 5.9 8.4 0.0 21 47 229 255 225 262 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	5	3.4e+03	-0.5	0.0	27	44	11	28	3	32	0.82
2	9	0.0015	1	10.8	0.1	21	51	33	63	27	66	0.86
3	9	5.2	3.5e+03	-0.5	0.0	22	46	62	86	59	92	0.85
4	9	1.3	8.8e+02	1.4	0.0	26	48	94	116	85	121	0.79
5	9	1.8	1.2e+03	1.0	0.0	21	52	117	148	113	149	0.87
6	9	0.018	12	7.4	0.2	21	48	145	172	139	176	0.86
7	9	0.11	72	4.9	0.0	22	45	174	197	171	200	0.87
8	9	0.0061	4.1	8.9	0.0	21	44	201	224	197	228	0.90
9	9	0.0087	5.9	8.4	0.0	21	47	229	255	225	262	0.85

Coding Sequence: ATGAGTCAACCAGGGGAGAAGCTATACCCCTGCGTCGAGTGCGGTAAAGCATTCAAACGTTCGAATAACTTGAAAATACATATGCGGAATCACACTGGTGAAAGGCCGTTCAAATGTGCCGTTTGTGATTCGACATTCTCGCAGTCGGCTCACCTGACGAGGCACATGatgattcacactggtgagaaaccatacaaatgtcaCCAGTGCGATAAAACTTTTTCCGAATCCTTTCAACTGAAAGGACACAttaggattcacactggtgaaaaactgTTCATgtgtgtcgagtgtgataagGCTTTCCTACAATCAAGTCACCTAACAAGACACATGatgattcacactggtgaaaaacctttCAAGTGTCTCGAGTGTGGGAAAGCGTTTGCTGAATCGAGTCAACTAAAAGGTCACATTAGGCTTCACacgggtgaaaagccatttaagtgCGCTGCGTGTGATAAAGCATTTTCACAGTCGTGCCACCTGACGAGGCACATGATGATCCACACTGGTCAAAAGCCTTACAATTGCCCCATGTGTGACAAGACGTTTGCTCGATCCAGCCACCTTAAGGATCACATCAGCGTCCACACCGGCGAAAACCCGTACAGATGCGTCGTGTGCGGTAAAGCGTTCAAAGTTTCACGAAATTTGAAAGTGCACATGAGGAATCACACCGGCGAGAAGCCGTTCAAGTGTACCGAGTGCGATTCGATATTCGCCCAGTCGGGGCACCTGAAGAGACACAAGATGATTCACACCGGCGAGAAACCACACCGGTGTCTCGAGTGCGGCAAAACGTTTGCCGGGTCCAATCAACTTAAGGGCCACGTTAGGATTCACGCTGCCGAGAGGCCTTACTGA
Protein Sequence: MSQPGEKLYPCVECGKAFKRSNNLKIHMRNHTGERPFKCAVCDSTFSQSAHLTRHMMIHTGEKPYKCHQCDKTFSESFQLKGHIRIHTGEKLFMCVECDKAFLQSSHLTRHMMIHTGEKPFKCLECGKAFAESSQLKGHIRLHTGEKPFKCAACDKAFSQSCHLTRHMMIHTGQKPYNCPMCDKTFARSSHLKDHISVHTGENPYRCVVCGKAFKVSRNLKVHMRNHTGEKPFKCTECDSIFAQSGHLKRHKMIHTGEKPHRCLECGKTFAGSNQLKGHVRIHAAERPY

Sequence clustering based on sequence similarity using MMseqs2