Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 6.9 4.7e+03 -0.9 0.0 22 52 8 38 4 39 0.75

2 8 0.042 28 6.2 0.0 23 52 37 66 30 67 0.86

3 8 0.0025 1.7 10.1 0.0 21 52 63 94 60 95 0.91

4 8 0.067 46 5.6 0.0 27 52 122 147 119 148 0.85

5 8 0.49 3.3e+02 2.8 0.0 21 52 144 175 142 177 0.86

6 8 0.1 70 5.0 0.0 21 48 200 227 192 231 0.85

7 8 0.036 25 6.4 0.0 21 52 228 259 224 261 0.88

8 8 0.61 4.2e+02 2.5 0.0 22 46 257 281 253 283 0.89

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	6.9	4.7e+03	-0.9	22	52	8	38	4	39	0.75
2	8	0.042	28	6.2	23	52	37	66	30	67	0.86
3	8	0.0025	1.7	10.1	21	52	63	94	60	95	0.91
4	8	0.067	46	5.6	27	52	122	147	119	148	0.85
5	8	0.49	3.3e+02	2.8	21	52	144	175	142	177	0.86
6	8	0.1	70	5.0	21	48	200	227	192	231	0.85
7	8	0.036	25	6.4	21	52	228	259	224	261	0.88
8	8	0.61	4.2e+02	2.5	22	46	257	281	253	283	0.89

Coding Sequence: ATGTTTGATTCAGCCTCTGATAAAAAGCCATACAATTGTGTTGTGTGCCCAGAATCATTCGCAGGTGCAAGTGAATTAAAAGTGCATATGCGAATTCACAATGGAGTCAAACCTTAcaagtgtgttgagtgtgaaCAAATATTCTCCAAATCATTTAACCTAACAAGACACATGAAAATTcatactggtgagaaaccatacaaatgtgttttaTGTGGCAAAACATTTAGCCAATCAGGTAACCTTACAAACCACATGAGGCTTCACAAAGGTGataagccatacaaatgtgttgagacTTTTGGAGCAttaatagttccaagtgaattAAATGTGCATATGGGGATACACACAGGATACAGGTGTGTTGAGTGTGAACAAGTATTCTCAAAATCATTTAACCTAACAAGACACATGAatattcacactggtgaaaaaccatacaaatgtgccaACTGTGGTAAATCATTTTCACAATCTAGTGGCCTAACAAAtcatatgaggattcacactggtgataaaccataccagtgtgttgagtgtgaccaaacattttcagtatcAAGTTCCTTAAAAAAGCATATAAGGACacatacaggtgaaaaaccatttaaatgtgttttatgtGGCAAAACATTCTCAGAATCAAGTTCCCTTAAAaagcacatgaggattcatacaggtgaaaaaccataccaGTGTGTTGAATGTGACACTGTGTTCTCACAATCAAGTCACCTAATAACACACATGAAAATTCACACTGGTGacaagccatacaaatgtgttgaatgttttaaaacattctctGTATCAAGCCACCTAACCAGACACATGaagattcacactggtgaaaaccTAAACAAATGTACTGAGATGTTCTCAGAATCTGCTTAA
Protein Sequence: MFDSASDKKPYNCVVCPESFAGASELKVHMRIHNGVKPYKCVECEQIFSKSFNLTRHMKIHTGEKPYKCVLCGKTFSQSGNLTNHMRLHKGDKPYKCVETFGALIVPSELNVHMGIHTGYRCVECEQVFSKSFNLTRHMNIHTGEKPYKCANCGKSFSQSSGLTNHMRIHTGDKPYQCVECDQTFSVSSSLKKHIRTHTGEKPFKCVLCGKTFSESSSLKKHMRIHTGEKPYQCVECDTVFSQSSHLITHMKIHTGDKPYKCVECFKTFSVSSHLTRHMKIHTGENLNKCTEMFSESA

Sequence clustering based on sequence similarity using MMseqs2