Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0029 2 9.9 0.1 21 46 47 72 37 78 0.90

2 7 0.0023 1.5 10.3 0.1 21 51 103 133 95 136 0.85

3 7 5.1 3.5e+03 -0.5 0.0 21 51 159 189 142 191 0.79

4 7 0.086 58 5.2 0.1 23 48 189 212 177 219 0.83

5 7 2.7 1.8e+03 0.4 0.0 21 52 215 246 212 247 0.84

6 7 0.73 4.9e+02 2.2 0.0 21 45 243 267 240 271 0.90

7 7 0.0002 0.13 13.7 0.1 21 46 271 296 267 298 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0029	2	9.9	0.1	21	46	47	72	37	78	0.90
2	7	0.0023	1.5	10.3	0.1	21	51	103	133	95	136	0.85
3	7	5.1	3.5e+03	-0.5	0.0	21	51	159	189	142	191	0.79
4	7	0.086	58	5.2	0.1	23	48	189	212	177	219	0.83
5	7	2.7	1.8e+03	0.4	0.0	21	52	215	246	212	247	0.84
6	7	0.73	4.9e+02	2.2	0.0	21	45	243	267	240	271	0.90
7	7	0.0002	0.13	13.7	0.1	21	46	271	296	267	298	0.91

Coding Sequence: ATGACTCAATCATTCACACAATCGTCTATACTAACAGAACACATGATTCATAATGGTGAGAAACCATTTAGATGTTCCGAGTGTGGTGAGTCATTGTCAACCGCAAGTAGTTTAACAGAGCATATGCAGGTTCACGACGGTGAAAAGCCTCTTATATGTGTGGAGTGCTTTAAAAGATTTCGCAACTCGAGTAATTTGAATaaacatatgaggattcatactggtgaaaagcgCTTTAAATGTGTAGAGTGTAACAAAACGTTCACACAATCTTCTCACTTAGCAAACCACAAGAGGACACACACTGGAGAAAAGCCATTCAAATGTTCCGAGTGtgatataaaattcaaacaatccTGTGTACTTAGAAGACACATGAtgattcacactggtgataaGCCATTTAGATGTTCCGAGTGTTGTAGGACATTCACAACACCGGGTAACTTAAAATATCACATGTGGATCCACACGGCcgaaaaaccatttaaatgtgtcgAGTGCGATAAAGCATTCACACTATCTTCTACCCTAGCAAATCACATGCGAATTCACAGTGGTGTGAAACCGTTTAGATGTGTTGAGTGTCTTAAGTCATTCAGTGATTCAAGGAATTTGAAAGTGCATATGAGGCatcatactggtgaaaagccatttcagtgtgttgagtgtgatacaaAATTCACAACATCCTCTATACTAAAAAAACACATGTTGATTCATACTTGTGAAAAACCATTCAGATGTTCCGAGTGTGGTAAGACGTTCACATCTTCAGGGAATTTGAAAGATCATATGCGTGTccatactggtgaaaaacctTTCAAATGCTTTCTGTGTTATAAAACATTCACACAATCCTCTACACTGAGAAAACATGCGAGACTTCATTGTGGTGAAATGTGTTAA
Protein Sequence: MTQSFTQSSILTEHMIHNGEKPFRCSECGESLSTASSLTEHMQVHDGEKPLICVECFKRFRNSSNLNKHMRIHTGEKRFKCVECNKTFTQSSHLANHKRTHTGEKPFKCSECDIKFKQSCVLRRHMMIHTGDKPFRCSECCRTFTTPGNLKYHMWIHTAEKPFKCVECDKAFTLSSTLANHMRIHSGVKPFRCVECLKSFSDSRNLKVHMRHHTGEKPFQCVECDTKFTTSSILKKHMLIHTCEKPFRCSECGKTFTSSGNLKDHMRVHTGEKPFKCFLCYKTFTQSSTLRKHARLHCGEMC

Sequence clustering based on sequence similarity using MMseqs2