Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 1.6 1.1e+03 1.2 0.0 20 51 39 70 26 72 0.79

2 8 2.1 1.4e+03 0.8 0.0 21 48 68 95 64 99 0.84

3 8 6.5e-05 0.044 15.2 0.1 21 51 96 126 89 128 0.86

4 8 0.0011 0.72 11.3 0.0 21 48 152 179 144 183 0.85

5 8 0.24 1.6e+02 3.8 0.3 21 51 180 210 176 213 0.86

6 8 0.023 15 7.1 0.1 21 51 236 266 226 268 0.85

7 8 0.059 40 5.7 0.0 21 52 264 295 262 297 0.88

8 8 0.69 4.7e+02 2.3 0.0 21 44 292 315 287 318 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	1.6	1.1e+03	1.2	0.0	20	51	39	70	26	72	0.79
2	8	2.1	1.4e+03	0.8	0.0	21	48	68	95	64	99	0.84
3	8	6.5e-05	0.044	15.2	0.1	21	51	96	126	89	128	0.86
4	8	0.0011	0.72	11.3	0.0	21	48	152	179	144	183	0.85
5	8	0.24	1.6e+02	3.8	0.3	21	51	180	210	176	213	0.86
6	8	0.023	15	7.1	0.1	21	51	236	266	226	268	0.85
7	8	0.059	40	5.7	0.0	21	52	264	295	262	297	0.88
8	8	0.69	4.7e+02	2.3	0.0	21	44	292	315	287	318	0.88

Coding Sequence: ATGACTGATTCAGGTAGTTCCATAACACATACACATAGGCTGACATACAAATCTGTTCAGTATCGTAACAAAAATTCAGACTCAAGTAACACAAATAAGCACATTACATTTCACAATGGAGAGAAGTCTTACAAATGCGTTGAGTGTGATCAAATCTTCTCTCAATCATCTACTTTAATaaaccacatgaggattcacactggtgaaaaaccgtACCAATGTGGTGACTGTGAAAAGACATTTGCGAGGTCAGATCACTTAAGCAAGCACATGAGGATGCAtactggtgagaagccatacaaatgtgttgtcTGTTACAAAACATTCTCTCAATCATCTACTTTAAGAAACCACATGAGAGTTCATACTGGGGAAAAGCCATATAAATGTgatgagtgtgataaaacatattCAGTATTATGTGATTTAACAAAACACAAAagaattcacacaggtgaaaagccttATACATGTCTTGTGTGTCATAAAGCATTCACTGATTCAGGTAATCTAACAcaacacatgaggattcatactggtgaaaagccatacaaatgcgTCCACTGCCACAAAGCATTTACCCAATCAGCTACTTTAATAAACCATAtcaggattcacactggtgaaaaaccataccaTTGTGGAGAATGTGATCAGAAATTTTCAGAATCAGCTCATCTGACTAAACATatgagaactcacactggtgagaggCCATACCAATGTGTCATATGTCATAAAACCTTCTCTGAATCATTTGATTTAAAAAGTCACATAAGGATTCATAccggtgaaaagccatacaaatgtgaaGTGTGTGATAAAACTTTCTCATTATCATCAAATTTAGCAAAACACAGAAGACTACACACGGGTGAAAAGCCACACAAATGTGTAGTATGTGATAAAACGTTCTCTGCATCAAGTACCCTAACAAAACACATGAAAAGTCACACGGATGAGAACACAGAACTAGGCCCTGTTTCATAA
Protein Sequence: MTDSGSSITHTHRLTYKSVQYRNKNSDSSNTNKHITFHNGEKSYKCVECDQIFSQSSTLINHMRIHTGEKPYQCGDCEKTFARSDHLSKHMRMHTGEKPYKCVVCYKTFSQSSTLRNHMRVHTGEKPYKCDECDKTYSVLCDLTKHKRIHTGEKPYTCLVCHKAFTDSGNLTQHMRIHTGEKPYKCVHCHKAFTQSATLINHIRIHTGEKPYHCGECDQKFSESAHLTKHMRTHTGERPYQCVICHKTFSESFDLKSHIRIHTGEKPYKCEVCDKTFSLSSNLAKHRRLHTGEKPHKCVVCDKTFSASSTLTKHMKSHTDENTELGPVS

Sequence clustering based on sequence similarity using MMseqs2