Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 1.5 9.9e+02 1.3 0.0 26 44 8 26 2 30 0.80

2 10 0.024 16 7.0 0.0 21 46 31 56 28 58 0.91

3 10 0.014 9.3 7.8 0.0 21 46 59 84 55 90 0.86

4 10 1.4 9.7e+02 1.3 0.0 21 44 87 110 84 114 0.88

5 10 0.12 80 4.8 0.1 21 52 115 146 110 148 0.88

6 10 1.4 9.7e+02 1.3 0.0 21 44 143 166 140 170 0.86

7 10 0.67 4.5e+02 2.4 0.0 21 46 171 196 160 202 0.85

8 10 0.84 5.7e+02 2.0 0.0 21 48 199 226 196 231 0.85

9 10 1.1 7.6e+02 1.6 0.0 23 44 229 250 225 254 0.87

10 10 0.00017 0.12 13.8 0.2 17 45 250 279 243 286 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	1.5	9.9e+02	1.3	0.0	26	44	8	26	2	30	0.80
2	10	0.024	16	7.0	0.0	21	46	31	56	28	58	0.91
3	10	0.014	9.3	7.8	0.0	21	46	59	84	55	90	0.86
4	10	1.4	9.7e+02	1.3	0.0	21	44	87	110	84	114	0.88
5	10	0.12	80	4.8	0.1	21	52	115	146	110	148	0.88
6	10	1.4	9.7e+02	1.3	0.0	21	44	143	166	140	170	0.86
7	10	0.67	4.5e+02	2.4	0.0	21	46	171	196	160	202	0.85
8	10	0.84	5.7e+02	2.0	0.0	21	48	199	226	196	231	0.85
9	10	1.1	7.6e+02	1.6	0.0	23	44	229	250	225	254	0.87
10	10	0.00017	0.12	13.8	0.2	17	45	250	279	243	286	0.80

Coding Sequence: ATGTCTGAGTCGGAGACGTTTAAATGTGCCGAGTGTGATAAGACATTTACATATTCGAGAGGTTTAAAAAGACATACGCTCGTTCACACCGGTgagaagccatttaaatgtgtcgagtgtttTAAGTCATTCGCAGAGTCGCAACACTTGAAGAGGCATATGAAGATTCATACGGGTGAAAGGCCTTTTAAATGCGTTGAATGTTTCAAGTCATTCAGGGAATCGTTTGATTTAAGAACACACATCCTGATTCACACTGGCGAGAAGCCATATAAATGTTCCGAGTGTTTTAAATCGTTCACGACATCAAGCAGCCTGAAAACGCACACGAGGATTCACACAGGCGAAAGGCCATTCAAATGTGTTCAGTGCGATACATCGTTCCCACAATCGGCTGAACTTACAAAACACGTGCGAATTCACACCGGGGAAAAGCCATATGTATGCGTCGTCTGTGATAAGACGTTCACTAATTCAAGCACTTTAACGCAACATAAGAGGATTCACACCGGGGAAAGGCCATTTAAATGCGTCGAGTGTTTTAAATCGTTCACAACGTCAAGCAGTCTGAAAACACATATGAGGtatcatacaggtgaaaagcctTTTATGTGTTTCGAGTGTTTCAAATCATTCACGACATCAAGCGATTTAAAAGTACATATCATGATTCACACCGGCAAAAAGCCGTTCGAATGTGTCGTGTGTTTCAAATCGTTCTCGATATCGAGtgctttaaaaaaacattcaaggattcatacaggtgagAAGCCTTTCGAGTGTGTCGTGTGTTTCAAATCGTTCACGCAATCGCAACATTTACAAAGACATATGCGGAATCATGCAGGTGTAAAGCCGTTTTAA
Protein Sequence: MSESETFKCAECDKTFTYSRGLKRHTLVHTGEKPFKCVECFKSFAESQHLKRHMKIHTGERPFKCVECFKSFRESFDLRTHILIHTGEKPYKCSECFKSFTTSSSLKTHTRIHTGERPFKCVQCDTSFPQSAELTKHVRIHTGEKPYVCVVCDKTFTNSSTLTQHKRIHTGERPFKCVECFKSFTTSSSLKTHMRYHTGEKPFMCFECFKSFTTSSDLKVHIMIHTGKKPFECVVCFKSFSISSALKKHSRIHTGEKPFECVVCFKSFTQSQHLQRHMRNHAGVKPF

Sequence clustering based on sequence similarity using MMseqs2