Basic Information

Insect: Eucera pruinosa
Gene Symbol: MBD-R2
Assembly: GCA_028830335.1
Location: JAMYCR010000015.1:1189427-1199399[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.4 8.8e+03 -2.8 0.0 45 60 401 416 399 434 0.76

2 2 5.2e-18 3.3e-14 53.0 0.2 6 69 541 604 536 612 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.4	8.8e+03	-2.8	0.0	45	60	401	416	399	434	0.76
2	2	5.2e-18	3.3e-14	53.0	0.2	6	69	541	604	536	612	0.91

Sequence Information

Coding Sequence: ATGATGCGGCGGCATATAGAACGGTCACACGTTAAAAAGATGCCGCCTGTAGGAACAATGAGAATGGCGCGCAAATGTTGCGTGCGTAGCTGTGAGGCCGATGTACAAGATGCACGTTCTAAAGGGTTACCGCTTCATAAATTTCCGAAAGATTCTGGTTTAAAAAACAAATGGTTGGCCAGTGGTGGATTTGAAGCAAACTTTAAGCCTTCACCGGGTCAAGTTGTTTGTCATAGGCATTTTAAACGGGCCGATTATGAAGCCGCTAAAGGACATAAATTACTTTTGCGTAAGGGCAGTGTTCCATCAGTTTTTGCAGATTATGATAATCATCCGGaTCCTGTGATTATGTCGGTGAAATCAACAACTTCTTATGCACAGGAAGATTTAGATCTTATTAATTCTGAAATTTTGAACTTAGAACAGTCTATATCTCCATTGAATTCAGATGACAAAACACTAAAATCGGATAGTTGTGGAGAAACATGTTCTTCTCGACCAGAATCATCAGGTGACTCCTTCAATTTACCAGAGTCAACAGAATTGGTTCGTAATGGATgcaaaaattcaaatgtaaaagaagaaattatgtCTTCGGTgaaacaagaaaatgaaaattcagaAATGGAAGTCAATACCATGGCAGTGCAATTAGGAATTGTAGAATCTGAAATAGCAATAAAACATATACAAAAGGATTTGACtattaaagaagaattaaaaagtaTCAAAATGGAAGATGAAAAAGTATTTGATAAACCAGAAGAACTAAAGCcaaaaatttttaatagatgcGGATTAAAATTTTTTCCTGGAGCTAAATTAGAAGCAAAAGATTTTAATGAGAAATGGTATTCAGTGAAGGTAGTTGAAACTGACTGGGATGAAAGAGAAGTCTTAATACGTTTTGACAAGTGGAGTTCAAGATTTGATGAGTGGATACCTATGGATAGTTCTAGATTACGTGTATTACAAACACAAGCAAATGAACAAACCTGGAACCTGACATCTCCGGAAGCCAAAATGAAAGACTTTTCAGTTGGAGAAAGGATACTCGCTACGTGGGCAGATGGAAGAAAATATCCAGCTAAAGTAAATGCCGTCTTAGGAAATGATAGGTATGATGTACTATTTGATGATGGATACGCAAAGACAATTAAATCATCAAAAATGACCAAAATCGCTACAACATCTACAAAGcAACCTAGTCAAATTGAAGAATATATAGGAAGCAAACAAGAAAGAAGAGACAAAAAAAGGAAGCATACAGTAATGGAGTTGTTTCATACACATTCTAGAAAACGTTCGAAAAATGAAACAGACAAATTAGCAAAAAAAGAAGCAATTACAATtaatgaaaatgaagaatacTTTTCAGAAAGTAAAATTGATTTAGATGGTACTTTGTTTGGACCTTGTTATGATCCAGGCACAGATTTGTTACGAGGATTTGATACTAATGTATCTAAAATAAAAgctttttctaaaaaaaagaaagagactCCTAAAAGTGATGTTGATCAGATAGAAGATGTGGGACCTGAATGGATAGATGGAGAACCTCAAGGAACTGAATCTTATATAGTAGATGGAAATGATGGACCGCGTAGATCAATAATAGTTGCAGATAAAAGGTTGCCACCAGGATGGCAAAAGCATTTTACTCAAAGAAAAGCTGGAACATCCGCTGGAAAATGGGATGTTTTGTTTCTCCATAAATCAACTGGGAAGAAGTTTAGATCAAAAAATGATATTAgagcatttatggaaaatcaagGACAATTTGATTTTGATCctgaaaaatttgatttttgtattcatcggaaaaagaaaaatcaaaaccAGAAAATAAAACTGGATGTTGTTATGGATACCCCCAAAAAGATTAAGACAATATTGCCTAAAACAAAGACAGCTACAGTAACTGATACTTCATTAGTTGTTCCCCCGAGTACACCAGTTACAAGTGTTGTAACTACTTCAACAACGTCTATCACAGATGGTGCTGTTTTTATTGGTGGACTTCGAGTAGAAATGGAGGACAGTGCTTATAAATGTCCAAAACAAGGATGTAGTAAAACATTTAGAAAGGAAAATCTTTTACAAATGCATATAAAGCATTATCATCCAGAGTATTCCAAATTTTTGGGATCTACACCAAATGTAGCAGATCTAGCCTATGCAAGAACGATTGGGGAATCAGTTGAAGATATTATTCCAAAAAAGTCAATTAATCTGTTAGAAAAGTGCAATAAATTTGGAAAAAGAAAGTCTATTCAAGATAGATCAGTATATGTTTCATCACCATCTGTTACGAGTACTGTTCCGCCTGTATCCCCAACAGTAATTGTACCAACAGTTCCAGAAACAGAGGATGATGTGgatcaaatagaaaaatgtaatgATGTACAAATAGAAGATATCAAAATGGACAGAATGTCCCCAACTTCTAGTCACAGTTTAGAGATAGATGATGAAACTGAGAAAAAACAAGAAGATATATGTGCAATGTCACCTGGAACATTATTTGatatgaaaattaaagaagagaaaACACAAAGTGGTATTAAAACTCTTTTCCCAGTAAGACCTGCAGTATCTTCCGAAATGCAGAGAATTGATAGATCAAAGTCTGTAGATGAAGCTATTCATATTGATAAAATGAAGGGTCAAAGAAAACGACAATTATCAGAATATAGTTCAGATATACCAAATAAGGGTAAAAAAAAACATGGTATTCAAGAATTTACAGATGAGTACGGTGATTTAGACGATAGTGGCATGGATACAGAAGGACCAACTGCACTTATGTACAGATATAGTCGTAGAAAATCAGATTCGAGAAGTGACGAAAACAGTCAAAATAgTCAACTAAATTGTGATTCTCGTGTTGAAAAAGATGATTCCTTAAAAGGGGATATTGGTAAAAAAGATACTAATGATGGGGAAGAAAACGAAGGGGTTATGATGATGATTAATGGAGAAATGGTAAAAGTGGAACAACTTCGTagagaagaaataataaattgtacttGTGGATTTATGGAAGAAGATGGTTTGATGATACAATGTGATCTTTGTTTGTGTTGGCAACATGGTCATTGTAATGCaatagaaagagaaaaggaTGTACCTGAAAAATATGTTTGCTTTATTTGTCGGAATCCATATCGGCAACGCCTATCTAAAAAGTATTTTCACGATCAAGATTGGATAAAGGAAGGAAAATTACCAACATTATCTAGTCGAACAAAAAATCAGAACCGAATTAATCAAAGAACAGCTATGTTAAAACGTTCTTATGATTTAGTTGCTGCCCTTTTACACGTACAACAAATTTTACACAGCTTAAGAGTTAAGATTAATGTAGCGCAAAAAAAAGATCATCCAAAATTATACCTTTGGGCCAAGAATtgggaaaaaattgaaataccgaAACCTGCTATGTCACCAGTACCAATCATGGAAGTTATTAAATCAGGAAAAGAATGTATAGATACTGCAAATGAAGGTTCTCGCCGAATCGaagtaaaaatggaaacaaaatacaatttgAAAGATGACCATGATGAAAAATCAATAGCTTCAGATTCTGAATTAATGAAGATATTAGAAGAAGATAATACAGCTCCAGATGAGTCTAAAATTAGCTGTAAAAAAGAAGATTTTACACGTCAAAGTAAGAGTCATATTCTTCTTGATGCCCTTACAAAAAATGATATTCCAGAAGAGAAATACAGAAATTCATTATCGTCGGAAGCGAAAACTGCTGATGCAGATTTATTAACTGATCAAACGAATATATCTGAAAATAATATATCTGCATCAACTACATTAATGAATCATACGCATGAAGAATTAAATGAACATGCAATGTCAGCACCGCTGCAACCTTTTATACCACAACCAGAAGCACCAATTGATCCAGGAGAATGTCGAATGCGATTATTAGAGCATATAGAACATTTTCAAACTCATATAGATgcaaaattaacatttattgaGGCACAAGTTTGTGCGTTAGAAGCCATGGATCCTGAAGATGAACCTACCTCAGATGTTCAGCCTCGAACGAAACAAACCGTACAAATGCTTCTTCGAGATTTGAACACAGTACGAAAATTAGCTGCTTTAtgttaa
Protein Sequence: MMRRHIERSHVKKMPPVGTMRMARKCCVRSCEADVQDARSKGLPLHKFPKDSGLKNKWLASGGFEANFKPSPGQVVCHRHFKRADYEAAKGHKLLLRKGSVPSVFADYDNHPDPVIMSVKSTTSYAQEDLDLINSEILNLEQSISPLNSDDKTLKSDSCGETCSSRPESSGDSFNLPESTELVRNGCKNSNVKEEIMSSVKQENENSEMEVNTMAVQLGIVESEIAIKHIQKDLTIKEELKSIKMEDEKVFDKPEELKPKIFNRCGLKFFPGAKLEAKDFNEKWYSVKVVETDWDEREVLIRFDKWSSRFDEWIPMDSSRLRVLQTQANEQTWNLTSPEAKMKDFSVGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYAKTIKSSKMTKIATTSTKQPSQIEEYIGSKQERRDKKRKHTVMELFHTHSRKRSKNETDKLAKKEAITINENEEYFSESKIDLDGTLFGPCYDPGTDLLRGFDTNVSKIKAFSKKKKETPKSDVDQIEDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSTGKKFRSKNDIRAFMENQGQFDFDPEKFDFCIHRKKKNQNQKIKLDVVMDTPKKIKTILPKTKTATVTDTSLVVPPSTPVTSVVTTSTTSITDGAVFIGGLRVEMEDSAYKCPKQGCSKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSINLLEKCNKFGKRKSIQDRSVYVSSPSVTSTVPPVSPTVIVPTVPETEDDVDQIEKCNDVQIEDIKMDRMSPTSSHSLEIDDETEKKQEDICAMSPGTLFDMKIKEEKTQSGIKTLFPVRPAVSSEMQRIDRSKSVDEAIHIDKMKGQRKRQLSEYSSDIPNKGKKKHGIQEFTDEYGDLDDSGMDTEGPTALMYRYSRRKSDSRSDENSQNSQLNCDSRVEKDDSLKGDIGKKDTNDGEENEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYVCFICRNPYRQRLSKKYFHDQDWIKEGKLPTLSSRTKNQNRINQRTAMLKRSYDLVAALLHVQQILHSLRVKINVAQKKDHPKLYLWAKNWEKIEIPKPAMSPVPIMEVIKSGKECIDTANEGSRRIEVKMETKYNLKDDHDEKSIASDSELMKILEEDNTAPDESKISCKKEDFTRQSKSHILLDALTKNDIPEEKYRNSLSSEAKTADADLLTDQTNISENNISASTTLMNHTHEELNEHAMSAPLQPFIPQPEAPIDPGECRMRLLEHIEHFQTHIDAKLTFIEAQVCALEAMDPEDEPTSDVQPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01539602;
90% Identity: iTF_00676068;
80% Identity: iTF_00676068;