Epru015071.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Eucera pruinosa
Gene Symbol
FOXD3
Assembly
GCA_028830335.1
Location
JAMYCR010000010.1:5478848-5479921[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.2e-40 3e-37 127.4 0.0 2 87 106 190 105 191 0.97

Sequence Information

Coding Sequence
ATGGAACCGCGTGGGATGATGATGTCGAATCTGTCGTGCGACGGCTGCGCGGACAGCGACCGCGATTCCGACAGCAGCAGCATGATCGTGGACCCGGTGAGTTTGGACAAGAACGACCTGTCACCGTCCCAATCGTCGTCCAGCCCGATAATCCCGAGTTCTCCAGTGCCGGCGTCCACCGCGTCGTCACGAAACCGCGGCGGAAGTCGCAGCAAAAAGACTTACTCAATGATGTCGGCTACCAATCAACAGAAGAACAATCCCTCCGGGCAAGCGCCGTCTTACGGCAACGACAAAATGTCCTCGTCCCTAATCAAGCCCCCGTACTCTTACATAGCTCTAATCACAATGGCGATCCTTCAATCGCCCCAAAAGAAGCTCACCCTAAGCGGAATCTGCGAATTTATCATGTCCAGATTCCCTTACTACCACGACAAGTTCCCCGCATGGCAGAACTCCATCAGACACAATCTATCTTTAAACGATTGCTTCATAAAGATACCCAGGGAGCCAGGAAACCCTGGAAAGGGTAATTATTGGACCCTGGATCCTCTAGCCGAGGATATGTTCGACAACGGAAGTTTCTTGCGTCGCAGGAAGAGGTACAAAAGGCCTCCGCCGCATTACGTTCTTCGGGACAGGGCGATAATGGCGACTTTTGCCATTTGCGGCGATCGAGGACCTTGTCCTGGCGGCGGTGGTGGTCATCCGGGTGCTTTGACTTATCCTAGTGCCGCGTATCTCTCTCCGCCGCCCGGTCTACCTTTGCTAGACTTCTCCCCGTCGACGTTGGAAGCTTTGAAGCTCGGCGGTTTCCTGGAACCACCGCCGCCGTTGTACAAACCGGTACCTATCACGGCTCCACCGATCAGACAAATCGATCCTACACCGACGAGGACCACCACGATACCCAGCAGCCATCCGCCGGTTGACAAGAAGAGGAACTTTAGTATCGACGCGTTGATCGGTAAACAGGCAGCCAGCGATCAGAATTGCGGAGGATTGCTGGATCTCAGCCCGTCGGAGCACAGAGAGATCAGGAGTCAGGCGTCTGCTTTCTCTCCTTTGGTTTAG
Protein Sequence
MEPRGMMMSNLSCDGCADSDRDSDSSSMIVDPVSLDKNDLSPSQSSSSPIIPSSPVPASTASSRNRGGSRSKKTYSMMSATNQQKNNPSGQAPSYGNDKMSSSLIKPPYSYIALITMAILQSPQKKLTLSGICEFIMSRFPYYHDKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPLAEDMFDNGSFLRRRKRYKRPPPHYVLRDRAIMATFAICGDRGPCPGGGGGHPGALTYPSAAYLSPPPGLPLLDFSPSTLEALKLGGFLEPPPPLYKPVPITAPPIRQIDPTPTRTTTIPSSHPPVDKKRNFSIDALIGKQAASDQNCGGLLDLSPSEHREIRSQASAFSPLV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00738146; iTF_00769442; iTF_01015618; iTF_01406306; iTF_00773603; iTF_00864452; iTF_00024451; iTF_00865135; iTF_01408868; iTF_00128773; iTF_00126510; iTF_00125718; iTF_00127255; iTF_00127994; iTF_00129536; iTF_01355121; iTF_01099004; iTF_01066053; iTF_01066757; iTF_01068786; iTF_01065364; iTF_01069461; iTF_01070167; iTF_01067421; iTF_01068095; iTF_00867206; iTF_00085095; iTF_00088592; iTF_00084341; iTF_00085977; iTF_00087741; iTF_00086911; iTF_00965863; iTF_00861699; iTF_00183109; iTF_00862379; iTF_00360719; iTF_01070863; iTF_00183764; iTF_00866521; iTF_00360026; iTF_00863771; iTF_00865823; iTF_00760801; iTF_00223686; iTF_00226406; iTF_00216200; iTF_00214217; iTF_00220394; iTF_00218923; iTF_00222348; iTF_00229165; iTF_00232429; iTF_00221070; iTF_00221742; iTF_00227088; iTF_00229842; iTF_00224371; iTF_00233044; iTF_00214837; iTF_00216885; iTF_00218230; iTF_00230519; iTF_00223002; iTF_00225722; iTF_00231130; iTF_00227771; iTF_00219613; iTF_00225053; iTF_00231805; iTF_00217566; iTF_00228478; iTF_00215519; iTF_00763051; iTF_01122894; iTF_01122244; iTF_00684623; iTF_00683981; iTF_00863089; iTF_00860940; iTF_00016506; iTF_00015201; iTF_00762366; iTF_00625311; iTF_01453895; iTF_01476743; iTF_00181129; iTF_00014538; iTF_00182453; iTF_00015862; iTF_00181787; iTF_01475998; iTF_01520039; iTF_01407976; iTF_01523178; iTF_00898571; iTF_01270315; iTF_01269606; iTF_00765351; iTF_01268080; iTF_01266706; iTF_01268826; iTF_01267358; iTF_01271006; iTF_00867950; iTF_00452399; iTF_01087026; iTF_01498006; iTF_00391102; iTF_00733794; iTF_01419458; iTF_01418822; iTF_01420107; iTF_01420748; iTF_01417519; iTF_00983442; iTF_00873620; iTF_00982100; iTF_00982776; iTF_01418176; iTF_00961639; iTF_00962318; iTF_00963001; iTF_00963678; iTF_01168983; iTF_00729872; iTF_01077283; iTF_00109641; iTF_00280464; iTF_00729105; iTF_00730545; iTF_00884866; iTF_00279781; iTF_01245034; iTF_01477386; iTF_00264819; iTF_00264085; iTF_00417371; iTF_01405499; iTF_00385087; iTF_00306065; iTF_01254610; iTF_00142293; iTF_00140398; iTF_00141649; iTF_00141074; iTF_01539413; iTF_00117814; iTF_00756439; iTF_01421368; iTF_01422732; iTF_01423453; iTF_01422046; iTF_01424184; iTF_00633438; iTF_01407039;
90% Identity
iTF_01066053;
80% Identity
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