Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00036 2 9.2 0.0 21 52 66 97 57 99 0.87

2 6 0.14 7.5e+02 1.0 0.0 22 44 95 117 92 121 0.81

3 6 0.0013 7.4 7.4 0.0 21 47 122 148 118 153 0.86

4 6 0.0015 8.2 7.3 0.0 21 45 150 174 148 181 0.86

5 6 0.016 91 3.9 0.0 21 45 178 202 174 205 0.87

6 6 0.0012 6.9 7.5 0.1 21 48 206 233 203 236 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00036	2	9.2	0.0	21	52	66	97	57	99	0.87
2	6	0.14	7.5e+02	1.0	0.0	22	44	95	117	92	121	0.81
3	6	0.0013	7.4	7.4	0.0	21	47	122	148	118	153	0.86
4	6	0.0015	8.2	7.3	0.0	21	45	150	174	148	181	0.86
5	6	0.016	91	3.9	0.0	21	45	178	202	174	205	0.87
6	6	0.0012	6.9	7.5	0.1	21	48	206	233	203	236	0.90

Coding Sequence: ATGGTAGTAGGTGAGAAGAACACCACTGAAGAGGTGGATGATGTAATTGGAGTGATATATCTGGAAGACACTCGAAAAACAACATCGCCTCAACAACTGACAAATAATAATCGACAAACCTCAAATGGACCTAACCAGCTTGGAGATAAAAATCATTCGAACAAAAGTTTGACCAAGAATAACAATATTGACACTGGAGAACGACCCTATGGCTGTGATATATGTGGAAAATATTTTTCATGTTCAAGCAATTTAAAAAAACATTATAGAATACATACCGGAGATAAACCTTATGTGTGTGATATATGTGGAAACTATTTTTCACGTTCGGACCATTTAAATGTACATTATAGAATACATACTGGGGAAAAACCATATGGGTGTGAAATATGTGGAAAATCTTTTATACAATCAAAAACTCTAAAATTACATTATAGAATACACACCGGGGAAAAACCATATGAGTGTAAAATATGTGGAAAATCTTTTAGACTATCGGACAATTTAAATGTACATTATAGAACACATACCGGGGAAAAACCATATGGGTGTAATATATGCGGAAACTATTTTTCATATTCGAGCGTTTTAAAAAAACATTATAGAATACATACTGGGGAAAAACCTTACGAGTGTACTTTGTGTGGAAAATCTTTTACACAATCTTTTAATTGTACAAGACACGTGCAAAATGTACACAACAAAAACGATTTTTAA
Protein Sequence: MVVGEKNTTEEVDDVIGVIYLEDTRKTTSPQQLTNNNRQTSNGPNQLGDKNHSNKSLTKNNNIDTGERPYGCDICGKYFSCSSNLKKHYRIHTGDKPYVCDICGNYFSRSDHLNVHYRIHTGEKPYGCEICGKSFIQSKTLKLHYRIHTGEKPYECKICGKSFRLSDNLNVHYRTHTGEKPYGCNICGNYFSYSSVLKKHYRIHTGEKPYECTLCGKSFTQSFNCTRHVQNVHNKNDF

Sequence clustering based on sequence similarity using MMseqs2