Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.028 4.8e+02 1.9 0.0 15 48 86 119 77 122 0.86

2 6 0.0021 37 5.5 0.0 26 48 126 148 120 153 0.85

3 6 0.00097 17 6.6 0.0 21 52 149 180 147 181 0.88

4 6 0.00017 2.9 9.0 0.1 22 44 178 200 173 208 0.87

5 6 0.025 4.3e+02 2.1 0.0 21 44 205 228 202 231 0.88

6 6 0.0002 3.4 8.8 0.1 21 47 233 259 227 263 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.028	4.8e+02	1.9	0.0	15	48	86	119	77	122	0.86
2	6	0.0021	37	5.5	0.0	26	48	126	148	120	153	0.85
3	6	0.00097	17	6.6	0.0	21	52	149	180	147	181	0.88
4	6	0.00017	2.9	9.0	0.1	22	44	178	200	173	208	0.87
5	6	0.025	4.3e+02	2.1	0.0	21	44	205	228	202	231	0.88
6	6	0.0002	3.4	8.8	0.1	21	47	233	259	227	263	0.90

Coding Sequence: ATGGAAGCTAAAAAACTACCCGATGGTAATCCACATCTAACTAACGAACTATGGATGGAAAACCCTGTTCTCATTATGCCAGAAGTGGTAATGACGGAAGACcttatgaaaaaggaaaaaaacaatccATTGAATGTCACTTTAAATCCTCCTGTAATTTTACAATCGGTGGAATTCATGTATTCATCAATGAAACCACCAGAGTTCGACAAAAACGAGCAAGTTATGAGCCACCATATGATGAACAACGTTCCACCACCCAGTAACAGTAACAGTAACAGTGCCGTAATTTGTACGTGGTGTAAAAATCACTTTAAAGATAAAACTGACTTACTGAATCACATCAAACAAAACCATCCTGTTAATCGTTTGCATACTTGCTCGGAGTGTTCCAAAGTCTTTACccaaaaatctaatttaaaagCACACTACAGAGTACACACAGGCGAGAAGCCATTCAAATGTACCTACTGTCCAAAAATGTTCGCGCAAAAGTCAAATCTGATGAATCACTTGTCAGTGCACACGCGAGATAAACCATTTGGATGTCCTGTGTGTAAACGAGCCTTTTCACAAAGATCGAATCTCAAAAGTCATATATTCACTCATACCGGAGAAAAACCTTACAAGTGCAGTTTGTGCGACAAAGATTTTGTCCAAAAGTCAAACTTGACATGCCATGTGCGTACACATACCGCTGAAAAGCCACACCACTGTAATATATGTGATAAATATTTTAGTCAACGATCAAATTTGGTCAGCCATATGAAACTGCATGCGAAGGTTTCCGTGTAA
Protein Sequence: MEAKKLPDGNPHLTNELWMENPVLIMPEVVMTEDLMKKEKNNPLNVTLNPPVILQSVEFMYSSMKPPEFDKNEQVMSHHMMNNVPPPSNSNSNSAVICTWCKNHFKDKTDLLNHIKQNHPVNRLHTCSECSKVFTQKSNLKAHYRVHTGEKPFKCTYCPKMFAQKSNLMNHLSVHTRDKPFGCPVCKRAFSQRSNLKSHIFTHTGEKPYKCSLCDKDFVQKSNLTCHVRTHTAEKPHHCNICDKYFSQRSNLVSHMKLHAKVSV*

Sequence clustering based on sequence similarity using MMseqs2