Basic Information

Gene Symbol
-
Assembly
GCA_029851415.1
Location
CM056743.1:62994693-62995664[+]

Transcription Factor Domain

TF Family
HMGA
Domain
HMGA domain
PFAM
AnimalTFDB
TF Group
Unclassified Structure
Description
This entry represents the HMGA family, whose members contain DNA-binding domains, also known as AT hooks due to their ability to interact with the narrow minor groove of AT-rich DNA sequences. They play an important role in chromatin organisation [1]. The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [2].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.3 4.3e+03 -0.8 1.4 12 15 247 250 240 254 0.82
2 2 2.3e-08 7.7e-05 24.0 5.6 8 21 289 302 284 303 0.87

Sequence Information

Coding Sequence
ATGACAATACCACCTTACGCCGCCCATTGCAATCCAGCGGAACGATACATAAGAACAATCAAGACGTCCATTATCGCATATTTAGAGgaaaaacatagtcgctgggacgaaCATGTGACGGAACTTCAGTTCGCTTACAATACAAGCGTCCAGCACTCGACTCACCTCAGtccagcttttatgaactatggacgtaatccagttccacctaaaaatttcaaacgtcaacaagaaCTCACGTATGCTGAAAAAGAGCTGGTGCAAGCAGTAAATGATTGGCAAGCACATATGCTCAAACTGCCTGACTTGCACATGGTCGCAGCGACCAATTCAcaaaaagctcacgagcatcaagctcaatatTACAACAAAAAGCGACGTGATGTCCAATATGCAGTAGGAGATGCTGTCTGGAAGCGTAACAGAGTCTTATCATCACAGGCTCAGGGTATCACAGGCAAACTTGCGCCTAAATTCGATGGCAAATTTACCATCCTAGCTCGACTCGGTtcaaatgtttacgaactggccgatgaatcgggCCAAAGCATCGGGAAAGCGCATGTTCAAGACCTGAAACCCTACATCGATGGTGAAGAGCCCCTAAACGAACCAGAAATTGAACGGTCAATAATCGGTCCGTCAGACGACAACTCGTTCAATCAAGGACCATGTCGAGTGCTCAGACCAGCTAAAAACGTTGCGTCGAAGGCAAACACTCCAAAAATTACCAAGAAAAGAGGCCGACCAAGGAAAACCAAAATCGTGGTAACCAAAAAACGCGTCAGTTTCGTGCCCTCGATTCGTCATAAACGAGACAATGATACGGTCGACATAGCTCCGGCGCAGACGACCGAAACCATACCGAAACGACCGCGTGGTCGACCAAAAGGATCCACTAagaagaagatcttgaatgcgtcaaaCTTATCCCCTATGCGCACTAGATCTAGTAGTCGCTTGGCAAAATAG
Protein Sequence
MTIPPYAAHCNPAERYIRTIKTSIIAYLEEKHSRWDEHVTELQFAYNTSVQHSTHLSPAFMNYGRNPVPPKNFKRQQELTYAEKELVQAVNDWQAHMLKLPDLHMVAATNSQKAHEHQAQYYNKKRRDVQYAVGDAVWKRNRVLSSQAQGITGKLAPKFDGKFTILARLGSNVYELADESGQSIGKAHVQDLKPYIDGEEPLNEPEIERSIIGPSDDNSFNQGPCRVLRPAKNVASKANTPKITKKRGRPRKTKIVVTKKRVSFVPSIRHKRDNDTVDIAPAQTTETIPKRPRGRPKGSTKKKILNASNLSPMRTRSSSRLAK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00668437;
90% Identity
iTF_00668437;
80% Identity
-