Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 8.7e-05 5.4 7.9 0.1 44 78 8 43 5 63 0.75

2 4 1 6.1e+04 -8.2 32.1 459 493 65 99 37 111 0.69

3 4 1 6.1e+04 -8.5 22.1 442 484 138 178 131 185 0.70

4 4 4.6e-10 2.8e-05 25.3 2.4 324 382 196 255 185 273 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	8.7e-05	5.4	7.9	0.1	44	78	8	43	5	63	0.75
2	4	1	6.1e+04	-8.2	32.1	459	493	65	99	37	111	0.69
3	4	1	6.1e+04	-8.5	22.1	442	484	138	178	131	185	0.70
4	4	4.6e-10	2.8e-05	25.3	2.4	324	382	196	255	185	273	0.87

Coding Sequence: ATGGTAAACCCAGACGCGCACGACCGGACGACGCAGCAGATCCAGTCGAAGCTCGGTAACTACTCGCTGGTGAAGCACCTCCTCGACGAGCCGAAGCGACTTATCGGCATCGAGGGGGTGCCCGCAAGCCCTGCCCCCGGTGTCAATCCCAATCCCATCACATCCGCCATCACAGCGCCAAATAGTGGTGGAGGAGGTAATGGAAgctcttcgtcgtcgtcgtcaacgtcatcttcatcgtcgtcgtcgtcgtccagGTCCAGCCAGTCGAGTAGCGAGTTCAAAAAGCCTGGCGGCAATCCACGATCGAGTTCGAGCAGTAGCCAACAGAGGGGTGGTTTTGTCAAGCCCGCTGACGGTAAACCACCATACGGAGGCCGGGGTGGTTACCCTGGCCAGCCGGTCAAACACGCGAGCAGCAATAATGAGCACAGGAGTCATGGTCTTGCCCCAGCTAAGGGGCCACCTTCgtcttcatcgtcgtcgtcacaGCAATCGGGTGTATCGAATTCgacgtcatcgtcgtcgtcgtcgtccggactgCTGGGAGGCAACAGCGCGAGCTTGCACGGCAGATTGCACACGGCCAGCGTTCGGCTACCCAAGCTGCCCATCGATGCCAGCTCGAGCTCAAGGCATCTCAGCGCCGACAGTACCGCAGAGGTGGAGACAATTCTTAAGgaAATGACAAAGCCGCCAACGCCTCTGACTGCAATTGCTCAAACGCCAAGGAAGGAATTAGAGTCGAAATTTACTTTTAATCCGGATCTAGCTAAGCTGACTGAAATAACGCCTCCGGAAACAAAGCCACGTGAGTACCTCCATATGAACTCATTCACCTATATAGTACCCCAAAAAATTCACACCCCATCAACTGGAACGAGTCGGCCGGATTTTAATCCCTCCTTGACATTCTCACCCACAGCAATTGCTATATCATGA
Protein Sequence: MVNPDAHDRTTQQIQSKLGNYSLVKHLLDEPKRLIGIEGVPASPAPGVNPNPITSAITAPNSGGGGNGSSSSSSSTSSSSSSSSSRSSQSSSEFKKPGGNPRSSSSSSQQRGGFVKPADGKPPYGGRGGYPGQPVKHASSNNEHRSHGLAPAKGPPSSSSSSSQQSGVSNSTSSSSSSSGLLGGNSASLHGRLHTASVRLPKLPIDASSSSRHLSADSTAEVETILKEMTKPPTPLTAIAQTPRKELESKFTFNPDLAKLTEITPPETKPREYLHMNSFTYIVPQKIHTPSTGTSRPDFNPSLTFSPTAIAIS

Sequence clustering based on sequence similarity using MMseqs2