Basic Information

Gene Symbol
E2f8
Assembly
GCA_029851415.1
Location
CM056742.1:38658454-38661205[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.2e-25 3.4e-21 76.5 0.0 1 65 100 168 100 168 0.94
2 2 3.1e-19 4.8e-15 56.8 0.2 3 58 238 319 236 326 0.88

Sequence Information

Coding Sequence
ATGTCAGGACAAGGTACTCCGGAGCGTAGAATCCTGGGCGAGTTGGGCAATAACCCGGACTCGCCCACGGCGAATTTGAGATTGCTCACCGCCCTCGCGTCCAGTTTGAAGCAGAGTAGTCCCACGACTAATAATACGGATTCGACCCCGACGACGACGTGCCCGAATATTAGCTCGATCGCATCCTCGAGTACTGATTCAATTCTACAAGTATCGAGTGTTTCAAGTACTCCGGAGCAGCAGCTGCTCGGAGTCAGTCCTGCCCGGGAGTCGGCCAACGGAAAACTTGTCCCACGCAAGGAGAAATCCCTTGGCCTTCTGTGCAATAGATTCTTGAACTTGTTCCCCTTGACTATTCAAGAAAATGCTCCAAAAGAAATATCACTCAACTCCACTGCTCAAACTCTTGGTACAGAAAAGCGTAGAATATATGACATTATCAATGTCTTGGAGAGTTTGGAGATGGCATCAAAAGCTGGGAAAAACCAATATTACTGGCACGGACAATCGCGATTGCCAGCGACCTTAGCCAAGCTAAAGATGTCAGCCATGGAATTGGGATTAGAGAAACATATACAGGAAATACAAAAAGTCAACCGAGCATTTATTGAAGATACTTGTCAGTCAAAGAACAATTCTTCTGCATCGCTTATGGTTCCTCAAAGTCCAGTCGTTAATTATTGTTTTCCTGATGCTTGTGACAGAGAAGTTAAGAGCTTAGGTGTGATGTGCCGTAGATTTGTGATGCTCTTTCTTGTATCCATGGAGAATGGTGTTATAAATCTAGACATTGCAGCAAAAGTTTTAATCAATGAGTATGACATGATTGACGCTAAAAGTAGTGCAGTCCAATCGCGATTCAAAACAAAAGTGAGAAGACTTTATGACATTGCCAATGTCTTATCAGCTATTGGATTGATAGAAAAAGTTGATTTGTATAATTGTGCTATTAGGAAACCAATTTTTAAATATACAGGTCCCAAAGTCGACTGTCTAAATTTGAATCCTGATTCTCCTCTTACCGAAAATGGAAACAAATCTCTAATTGAAATGACTACACCGAACAAGAAATCTTCAGACACTCGGCGCTTCCGGACtttgagcagaatttcaagacTGTGTTCGAGTACTCCATCAGGGACCAAACGTGAACCAAAAAAACGGAAGCTTTTCGACTCAGAAACGAAATTTCAGCGCACTCAGAGTTCGCCTTGTCTTAGCACAGCTAAAGGCCGCATGTCAGATATGTTGGATGATTCAATTCTCCAAGTAGTTGAAATGGAACTTGAGCGAATGAAGTCAAGTGAGCTTAAACCAAGAGTTTGTACTAAACTTTTTCCGAGGCACAACTCAGATTCCTGTATACTACCTTCGAGTGCATACACCGACATTTCGACTGCAAGTGAAAATTCAGAATCTAACGCAGATGCGTCAACTTCGAGTGGGCATCTGAGTGACAGCCCGATTGCTCTTCCAGTAGTCAGTAAAGAGAATCTAGTCAACCAATCAACTGAGGTGGTCACTCCGGCTCGTACTTTACGAATCAACGTACCCGTAGAGCTCAAAATAACCCCGGTTACAGTACAGCAATGTTCCACTCCTAAATTTGTGAGACTCACCAATTTGGACCTCAAAAAATTGGTGCCTATTTCAAAAGAGAGTATACAATTGAAGATGCCCACAACGAAGCCTGCATCTGCTCAGACGAATCCAAAGTCGAATATAGCTATTCTGACCCAGATTCCTagtagaaaaatttctcctggGGATACTTTCAAAGCTATCAAAGTCGGCAATACCTTCCAATTAGTTCCCTTTGAAAGCAAAAGTGATAGCAAAGAGAAATAG
Protein Sequence
MSGQGTPERRILGELGNNPDSPTANLRLLTALASSLKQSSPTTNNTDSTPTTTCPNISSIASSSTDSILQVSSVSSTPEQQLLGVSPARESANGKLVPRKEKSLGLLCNRFLNLFPLTIQENAPKEISLNSTAQTLGTEKRRIYDIINVLESLEMASKAGKNQYYWHGQSRLPATLAKLKMSAMELGLEKHIQEIQKVNRAFIEDTCQSKNNSSASLMVPQSPVVNYCFPDACDREVKSLGVMCRRFVMLFLVSMENGVINLDIAAKVLINEYDMIDAKSSAVQSRFKTKVRRLYDIANVLSAIGLIEKVDLYNCAIRKPIFKYTGPKVDCLNLNPDSPLTENGNKSLIEMTTPNKKSSDTRRFRTLSRISRLCSSTPSGTKREPKKRKLFDSETKFQRTQSSPCLSTAKGRMSDMLDDSILQVVEMELERMKSSELKPRVCTKLFPRHNSDSCILPSSAYTDISTASENSESNADASTSSGHLSDSPIALPVVSKENLVNQSTEVVTPARTLRINVPVELKITPVTVQQCSTPKFVRLTNLDLKKLVPISKESIQLKMPTTKPASAQTNPKSNIAILTQIPSRKISPGDTFKAIKVGNTFQLVPFESKSDSKEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-