Eoch009488.1
Basic Information
- Insect
- Eremobia ochroleuca
- Gene Symbol
- -
- Assembly
- GCA_949629135.1
- Location
- OX451389.1:17757370-17757870[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.2e-07 0.0001 23.2 0.4 25 76 10 60 3 116 0.87
Sequence Information
- Coding Sequence
- atgagTGATAAAGCGATAAGGGCCGGTAAACTTATAGCCCTACTTGAAGAAGGTTGTTCGCAAACTTACGTGTCTCAGCGGCTAAATGTGAGTCGTTCAACTGTCCAGAGGACTTGGCAACGGTATCAAGAAACCGGTTCGGTCAAAAGAAGACCTGGTTCGGGAAGAAAACGATGCACAGAACCAAGAGATGACCGCTTTTTGGTGAGTCAGGCGTTGCGGAATCGTAAGGCGTCAAGTGTGGACCTGAAGAAGAGCCTTGAAGAAGTAAGAGGAGTAGAAGTTAGCTTGTGGACGGTCAGGAGGAGGCTTTTGGCTGCCAATATCAGGAGTTACCGCCCAGCTCGGGGCCCTAAATTACTCCGTGAGCACCGTGTTGCTCGACTTCAGTTTGCTCGAAACTGTGCTTCATGGACTCTGGAGGACTGGAATAAAGTATTGTTTTCTGATGAAGCTAGAATCTCTTTGTGTGGAGAGGGCCGACGCCGGCGAGTGCTGTGA
- Protein Sequence
- MSDKAIRAGKLIALLEEGCSQTYVSQRLNVSRSTVQRTWQRYQETGSVKRRPGSGRKRCTEPRDDRFLVSQALRNRKASSVDLKKSLEEVRGVEVSLWTVRRRLLAANIRSYRPARGPKLLREHRVARLQFARNCASWTLEDWNKVLFSDEARISLCGEGRRRRVL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00374081; iTF_00924641; iTF_00072130; iTF_00374088; iTF_01209238; iTF_01332648; iTF_01332682; iTF_01332643; iTF_00374092; iTF_01332642; iTF_00072132; iTF_00673476; iTF_01332644; iTF_01332645; iTF_01332646; iTF_00043463; iTF_00039785; iTF_00177098; iTF_01332654; iTF_01090740; iTF_00374072; iTF_01280251; iTF_01280252; iTF_01332639; iTF_01030185; iTF_00374093; iTF_01030193; iTF_01531989; iTF_01030198; iTF_00177096; iTF_00446106; iTF_00758139; iTF_01208159; iTF_00177088; iTF_00177089; iTF_00039786;
- 90% Identity
- iTF_00667457; iTF_00924641; iTF_00072132; iTF_01030185; iTF_00043475; iTF_01090740; iTF_00374070; iTF_00040791; iTF_00758136; iTF_00177087; iTF_00673476; iTF_01332645; iTF_01332644; iTF_01332646; iTF_00043463; iTF_01332682; iTF_01332643; iTF_01332654; iTF_01030193; iTF_01090737; iTF_01531989; iTF_01534805; iTF_01030198; iTF_00177096; iTF_00374072; iTF_00446106; iTF_00667451; iTF_00758139; iTF_01280251; iTF_00177098; iTF_01280252; iTF_00446109; iTF_00039786; iTF_00177089; iTF_00072130; iTF_00177090; iTF_01332642; iTF_00177091; iTF_01332648; iTF_00039785; iTF_00177085; iTF_00177088; iTF_00375187; iTF_01280254; iTF_01332673; iTF_01332672; iTF_01208159;
- 80% Identity
- -