Eoch033647.1
Basic Information
- Insect
- Eremobia ochroleuca
- Gene Symbol
- -
- Assembly
- GCA_949629135.1
- Location
- OX451414.1:6194594-6213328[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 0.016 13 6.7 0.1 18 62 293 337 287 378 0.84 2 3 0.00025 0.22 12.5 0.0 17 86 405 474 394 496 0.84 3 3 0.008 6.8 7.7 0.0 18 65 525 572 518 603 0.86
Sequence Information
- Coding Sequence
- ATGGCTCCTGTTACCCAGGATGAATTAAAGgtgtgCAGAGTTTGTCTAGCTTTAGATGTCAACATGTACAATATGAAAGATTTTAAATTGAGTGATATGTTCCAAAATATCACAGGAATAACGGCTACCGATAAAAGAGGCAATATACTACAGCGGATTTGTTGGGAGTGCGCTGCGCGCCTAACAGCAGCTGCAGCGTTCAGAGAAAAAGCGCTGCTCAGCGATGCATTGCTGAAAGACCAAGTACACATGAATGAAAGTGACATtgcattattaaaacaaaatcacaGTTCTCTAAAATCacctctatctattaaaacagcaGTTACTTCATACGATATTGAATGCGAACAAACTAcctctgaaaataaaaaaataaaaatattacgcaATGATGAGACAGATATGAAAGACAGAAAACATGAATTAAGAGTTGTtattgaagaagaaaaagagATGCAATTCGAACAGTACGAGGCTTGGATAGATGTTCCTGTGAAAACTGAGATAGAATCTGACCCTATAGCCGATAATAATATGCGATTTCAAGATCGAAACAGCGATATATTTTCGGAACAAACACATTTCAATGATGCGTCTCGCACAGAAGATAGAGAAGATGAAATGACAAATACTGAAGTACAAAAGAATTTGTGGCAATATATCCCAAAACAATTCCCGTACATAAATAACGATGGAAACATCGTTTTAGTggataaagagaaaaaaattaagCCTGATGTAATCGGTAACATTGTGGACGAGGCCTCGAGTGATGAAGACGTACTAAGTACAGCAGTATCTAGTAATGACTGTAAGCAAACGATGACCAGTGAGGTTGGGGATTCgaataaaaaagtaaaGCGGAAGTACGTGCTTAACGAGAGgattaaagaaaaaattattGAGATGAAGAATAACGGTCTCTCAGTCTCCGCAATATCTAAAGAAACTGGATGTACGatatcaTCTATAAACTGTTGGTGGAGACGCTACCGTAAAAGCGGTAACGGATATCAAAGATCTATTTATCCAGGATACCAGTACGCTTCAAAACAGTATTACTGTCACAACATTGCAGAACCTGGAAAAGAGATGGAGCCTTGTCCTGAAATAGTGAAGCAGAGATTGTGTGAAGCTGGGCTTGTACACATACTCATGAAGAAACCTGAAAGAACTGTGAATACGGGAATGAAAACTAGtACGCGTCAAGCGCTTCATGAAGATTTAAAACAGCGAATTGTTGCACTGAAGCAAGAAGGGATGTCTAACAGCCGGATAGCTTACCTGTTAAATACCGCACGAAACACAGTTCAAAAGTGGTGGAATCGCTGGTGCAATGAAGGGCACATGCAAAACTACAAGCAGCCCGGAAGGAAGAGAAAAACAACGCCTCAAGAAGACCAACTTTTAATAGAGCGGGTGACTCAGGAACAAACTGTGCATACGCCGTCCCTGGCTAAGGAATTTGGCATTTCTTTGaaGTGTCTGACAAATAGACTAAAGGAGGCAGGATTTAAAAACAAGACAAGAGAAGCTTACGTACCCTTGAAAGCGGGCCGGAGTCATAAAGTCGATGAGGAGATCAAACAACATATAATATCGATGAAACTGAATGGCGTTTCAGTCACCGACATCGCTAACCAATTTCGAGTGCCGcgtaCCACAATATACCAATGGTGGCAGCGCTGGTGTAAGGAAAACAACATAAAAGTAACAAGCAATACTACCACTACAGCTGAACAAGACATGAGTTTAGCAGAACAAACTACCGTCGAGAGGATTGTTCAAACGCCATCAGTAATGTCCTCACAGAAGTCGTTGTGGCAGAAAGCGCCCgatgtataa
- Protein Sequence
- MAPVTQDELKVCRVCLALDVNMYNMKDFKLSDMFQNITGITATDKRGNILQRICWECAARLTAAAAFREKALLSDALLKDQVHMNESDIALLKQNHSSLKSPLSIKTAVTSYDIECEQTTSENKKIKILRNDETDMKDRKHELRVVIEEEKEMQFEQYEAWIDVPVKTEIESDPIADNNMRFQDRNSDIFSEQTHFNDASRTEDREDEMTNTEVQKNLWQYIPKQFPYINNDGNIVLVDKEKKIKPDVIGNIVDEASSDEDVLSTAVSSNDCKQTMTSEVGDSNKKVKRKYVLNERIKEKIIEMKNNGLSVSAISKETGCTISSINCWWRRYRKSGNGYQRSIYPGYQYASKQYYCHNIAEPGKEMEPCPEIVKQRLCEAGLVHILMKKPERTVNTGMKTSTRQALHEDLKQRIVALKQEGMSNSRIAYLLNTARNTVQKWWNRWCNEGHMQNYKQPGRKRKTTPQEDQLLIERVTQEQTVHTPSLAKEFGISLKCLTNRLKEAGFKNKTREAYVPLKAGRSHKVDEEIKQHIISMKLNGVSVTDIANQFRVPRTTIYQWWQRWCKENNIKVTSNTTTTAEQDMSLAEQTTVERIVQTPSVMSSQKSLWQKAPDV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00924639;
- 90% Identity
- -
- 80% Identity
- -