Basic Information

Insect: Episyrphus balteatus
Gene Symbol: MBD-R2_1
Assembly: GCA_026256485.1
Location: JAGTYB010000040.1:1470089-1476779[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 8.8e-20 5.6e-16 58.7 0.0 3 76 397 468 395 469 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	8.8e-20	5.6e-16	58.7	0.0	3	76	397	468	395	469	0.93

Sequence Information

Coding Sequence: ATGGTCCGCCGATGTGTTATCGAAGGTTGCGAGTCCAAATCCTCGGTGCCTGAACACAAAGGTGTTACTTTTCATTCCTTTCCCTTTGATTCAAAAACAAGAGAAGTTTGGATTGAAAATTGTCACATCCCCGCCGACAAAAATATTACCAAGAATATTTTGGTCTGCTCCCGCCACTTCCGTCGTGCCGACTTTCAGCCCATCAAAAATGGAAAGTTTTTACTCAAAAGTGGCTCCATACCTACTGTATTTTCTTGGAAAAAGAATGATTCCAGCTCCAGCAGTATAGCCTCCGCTCCTGTCAGTCGAGTTAATAGTGAAGTGGCCGATGAAGCAGCAACAACTTCGACTGTTGAAGCCACTATAGCATCAATAATGGCGGAAACAGACAAACTTAACCGTGCTGCTGGTATCTCAACCAAAGACTTCAAACGTAAATCATCGCGATCCGACGAATCTCCAATGGCAAGTCCTCAACGTATAGCTACTCCGGTGAAAATTGATGTGCCGCTTGTTTTCACTCCTGGAGTGCGTTTAGAAGTTCAAGAGATAAATGGCCAGTGGCACTCTGGTAAGGTCGTTGAAGTGGACAACGATGATCGTGAGGTTCTGATAAAATTCGAAAAATCTGGTAAATCTAAACGTGCCGAATCCGAGGAGTGGATTCCAATGAACAGTCCGCGCTTAAGGCAAAAGGCATCAGCCAAACCTCCACCACTTTTTGTTACTGATGAGAAATGCTTCGCTCGTTGGACTGGATCACGCAAGTTTCCAGCAACTGTACAAAAGGTTCTTGGAGACGATTTATATGAAGTTCTATTCGAAGATGGATTCGTTAAGACGGTCAGAGGCAATCATATGGGAAAAATAAAAAGCGTGCCTGTGAAAGTGAGCACGCCTGCTCCTGTTGGCACTAAGATCGCCAAATCTCCAAAGTCCACTGCTAAACCTGAAAAAGCAGCTTTAGTAGAAGCAGCTGTTGCAAATGCAGAGGGTAGTAGTACAAAGACCACAAAGCCGAAGAAGTCACCCCGGAAAGACTGGCCACTCATTTCTATGGAGACATTAGATTTACCTTCATTGAATCTACCAGAAGTTCCACAAGATGGCGAATGGACTTGCCACTGGGTTAACGATCAACCTATTGGTCGAGAAGGTTTTCTCCTTATTGGAGAACATAAAAAACCTACAGTTATCGTTGATGATTGGCGACTTCCTCCAGACTGGGTCAAACATATGTATCAACGTTCGAATGTGCTCGGTAAATGGGATGTAATTCTAGTTAATCCAGCTGGCAAAAGATTTCGTTCTAAAGCTGATCTGAAACAAGCATTAGAAGATGCCGGTCAAGTGTATAATCCGGATATATATGACTTTAGTATTCACAGAAGACGTGCAAAAGATATCAATGCGTACGTTTACACTCCGGATTATAAACCACCACCTAAACCGGTGGCTGCTTCCTTAGCAAGTCCAACACCCAGCAGCACCGTCGAAATTCCAAGAACTTCGGTAATTGAAACTCCAATTGCTACTCCTATGCCTCCAATGGAGCTGATGACACCACCTCCAGCACCTAAACCAACTGAAGTTGTTTTGAAAGAAGAAGAAATCAAACTGGAATGCACAACACCAGAAAAGGTTCCTCTGCCAGAGCCTTTGGAAGATGGATTCGCATACATTGGGGGTCTTAAGGTGGAAATCATAGATAATCTTTTCCGTTGCCCTCAAACGGGGTGCTTTAAAAATTTCAGAAAAGAAAATCATTTGCAAATTCACGTCAAACACTATCACCAAGATTTAATCAAACTTTTAGGTGAGTGTCCAAATATGCAAGATCTAGCCCTAAAGAGAACTATTGGACACCCTGAAGCAGAACCGCAGCCCAAGAATCAAATTCCCAATCAGCAATTTTTCGCCAAGATGCATCAGATTGATCTTCAGTCACGTTCCCATCGTAAATCAAGTGCGAACACTGCACTGACTTTGTCTGCAATGACCTCACCAATCCATCAAACAGTAGCAGATGATATTCCATCAGCCCCAACATCGGCTGACGAATCAATAAATTTAAATTCTACTCAAGCAAACTCAACTTTAGATTCTTCGGTTTTAGGATCAGATGTCTCTTTAGTCACAGGCGATACTATTGTCAAAATGGAAGAACCCGATGCTGAAGTGTTACCGGTTGTTACACCTGTAATTGAAACTGTCACGGCCCCAGAACCAGTTCCTGATGTTCCGATCTTGCCACCAGCACCGAAAAAGTCTAAAATGTCAGTAATTAAGTCAGTTGCTAAATCAGTTAGCAAGAAAGTATCTAATCCTGGAGCGAGGAAGAGCAATCGCCAGAGGACTACAAAGAAATATCTCACTTCAACTCCTGCTGCAGCTGTTGTTTCTCACCCTACACCACCAATATTGGCATCTTCTTTTGATTCTAGCTTTGGAGGAACTGATTTTGAAGATTCTCGCCATTCGCTCAATGGTACTCCAGATAAGCCTGCAACTGTTCCAACAACAATTCAAACAACTACAGCGAAGAAGCCAAAACCAACTCCAGTTGTAACAAATGAGGCAATAACCACCGTTGAAGGTAGCTTGAGTGGTCTTGTAGACTCTGTTGAAACACCACAGTATATCAAGGAGAACGGAGAGCTTATCAAGATTGTTCGAATGAGGCAAGAAGAGATTATTAACTGTTTGTGCAATTACGGCGAAGAGGATGGCCTTATGATTCAATGCGAACTCTGTCTTTGCTGGCAACATGGAACATGCAATGGAATAGAGAAAGAAAGCGATGTTCCTGATAAATACGTTTGCGTCATCTGTAGTAATCCGCAATGTGGCCGAGAGAGTCGTAAGTATGTACACGATCAGGATTGGATGTATGAAGGAAAGCTGCCGGCGGCCAATTACCATGAGGAGAATCCAATGCATCCTGAGCGTTTTGAAATCCTTAAGAAAAGTCACACTCTCGCCGGGAATCTAGTCGAGCTAAAAAGATTCTTGCACAGCCTTCAGGTTAAGATAAATATAGCAGGGAATAAGGATCATCCAAAAATGTATCTTTGGGAGAAGCGCTGGGATCCCATACCCAAAGATGTTGTCAAGGTAGAGAATGATACTATTAAATTAGAAGATGGCGATACCGATATGAAGGATGTTAAGGCGCCTATTGACCCCGTCGAGTGTCAACACCGTTTACTAGAGCACATAAAAGTCCAACAAAACCTAGTTTTGAGTAGATTAGATGATATTGAAGCGCAAGTTAATGAACTCGAAGCAGCAGATAATTTACCTGACATGAAATCTGCCGACATAGAAGAAACAAAGGATGTATTAGCAACCTTTATAAAAGAACTAGAGATAATGAAGTCCATTGCAAAAATAAATGCGATGGTGCACAAAAAAAAGCAGCAAATGGTGCTGAATTAG
Protein Sequence: MVRRCVIEGCESKSSVPEHKGVTFHSFPFDSKTREVWIENCHIPADKNITKNILVCSRHFRRADFQPIKNGKFLLKSGSIPTVFSWKKNDSSSSSIASAPVSRVNSEVADEAATTSTVEATIASIMAETDKLNRAAGISTKDFKRKSSRSDESPMASPQRIATPVKIDVPLVFTPGVRLEVQEINGQWHSGKVVEVDNDDREVLIKFEKSGKSKRAESEEWIPMNSPRLRQKASAKPPPLFVTDEKCFARWTGSRKFPATVQKVLGDDLYEVLFEDGFVKTVRGNHMGKIKSVPVKVSTPAPVGTKIAKSPKSTAKPEKAALVEAAVANAEGSSTKTTKPKKSPRKDWPLISMETLDLPSLNLPEVPQDGEWTCHWVNDQPIGREGFLLIGEHKKPTVIVDDWRLPPDWVKHMYQRSNVLGKWDVILVNPAGKRFRSKADLKQALEDAGQVYNPDIYDFSIHRRRAKDINAYVYTPDYKPPPKPVAASLASPTPSSTVEIPRTSVIETPIATPMPPMELMTPPPAPKPTEVVLKEEEIKLECTTPEKVPLPEPLEDGFAYIGGLKVEIIDNLFRCPQTGCFKNFRKENHLQIHVKHYHQDLIKLLGECPNMQDLALKRTIGHPEAEPQPKNQIPNQQFFAKMHQIDLQSRSHRKSSANTALTLSAMTSPIHQTVADDIPSAPTSADESINLNSTQANSTLDSSVLGSDVSLVTGDTIVKMEEPDAEVLPVVTPVIETVTAPEPVPDVPILPPAPKKSKMSVIKSVAKSVSKKVSNPGARKSNRQRTTKKYLTSTPAAAVVSHPTPPILASSFDSSFGGTDFEDSRHSLNGTPDKPATVPTTIQTTTAKKPKPTPVVTNEAITTVEGSLSGLVDSVETPQYIKENGELIKIVRMRQEEIINCLCNYGEEDGLMIQCELCLCWQHGTCNGIEKESDVPDKYVCVICSNPQCGRESRKYVHDQDWMYEGKLPAANYHEENPMHPERFEILKKSHTLAGNLVELKRFLHSLQVKINIAGNKDHPKMYLWEKRWDPIPKDVVKVENDTIKLEDGDTDMKDVKAPIDPVECQHRLLEHIKVQQNLVLSRLDDIEAQVNELEAADNLPDMKSADIEETKDVLATFIKELEIMKSIAKINAMVHKKKQQMVLN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00426378;
90% Identity: iTF_00665679;
80% Identity: iTF_00665679;