Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.1e-39 2.4e-36 124.2 0.1 1 88 12 98 12 98 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.1e-39	2.4e-36	124.2	0.1	1	88	12	98	12	98	0.97

Coding Sequence: atgccGCGACCATCACGCGAATCTTACGGAGATCAAAAGCCGCCATATTCGTACATATCGCTAACTGCAATGGCAATTTGGAGCTCGCCGGAAAAAATGCTCCCACTGAgtgacatttataaatttatcacGGATCGGTTTCCGTATTATCGAAAAAACACCCAACGATGGCAGAATTCACTGCGACATAATTTAAGCTTTAACGACTGTTTTATCAAAGTTCCTCGAAGACCCGACCGACCGGGCAAAGGTGCCTATTGGGCGCTACATCCTCAAGCCTTTGACATGTTTGAAAATGGAAGTCTTTTGCGACGGAGGAAGCGTTTTAAGCTTCATAAAAATGACAAAGATTTGCTAAATGAAGAGTTGGCAGCATTGGCGAATTTAAATCGGTTCTTCTTTACAACCAATAATGCGCCAGCTCCGATGTGCCCACCACCCATGGCAGCAGATCCAACTATGTACATGCAACGCCTGCCGCCAATTGTGAATTCCTCACCTGTCCGACCGATTTCACCGTTGCAAACAACGACGCTAATTCATGATCGACCGAAAAGGTCATTCACGATTGAAAGCCTCATCACACCCGACAAGGATTCAATAATATCAGTCGATGATATTACGGTAGACGATCGGCCTGAGGAAGACGAAAGATTTTCACAGCGACACGTGCCCCTGCCACCATTGCACACGATAAACGCTGGCAATCTACCATTCCTGCATTATCCTTCACCAAATCCTGCTACCCTGGGATATGACCTACCAATGCATCCACTGCTTATGATAACAACTCCTCTGGGTGGATTTAATCCAGCGGCGTACTATCCAACCAACATCGGAATGCCGCATCATGCAGCTGAGCTGAATCATCGAATAAATGCTGGTCTAAGAACTGTGTAG
Protein Sequence: MPRPSRESYGDQKPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYRKNTQRWQNSLRHNLSFNDCFIKVPRRPDRPGKGAYWALHPQAFDMFENGSLLRRRKRFKLHKNDKDLLNEELAALANLNRFFFTTNNAPAPMCPPPMAADPTMYMQRLPPIVNSSPVRPISPLQTTTLIHDRPKRSFTIESLITPDKDSIISVDDITVDDRPEEDERFSQRHVPLPPLHTINAGNLPFLHYPSPNPATLGYDLPMHPLLMITTPLGGFNPAAYYPTNIGMPHHAAELNHRINAGLRTV

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01395639;
90% Identity: iTF_00665441; iTF_00974449; iTF_00664665; iTF_01211709; iTF_01356670; iTF_00984037; iTF_00893671; iTF_00976265; iTF_01396299; iTF_00426160; iTF_00426926; iTF_00187861; iTF_01318037; iTF_00693594; iTF_00694405; iTF_00334780;
80% Identity: -