Basic Information

Gene Symbol
ZEB2
Assembly
GCA_951394285.1
Location
OX596150.1:10733307-10734695[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.00065 0.044 14.7 0.2 3 23 152 172 151 172 0.98
2 11 1.5e-05 0.00098 19.9 0.9 1 23 178 201 178 201 0.97
3 11 1.1e-06 7.4e-05 23.4 0.3 1 23 209 231 209 231 0.98
4 11 0.00048 0.033 15.1 2.6 1 23 237 259 237 259 0.98
5 11 0.00093 0.062 14.2 1.8 1 23 265 287 265 287 0.97
6 11 9.2e-07 6.2e-05 23.7 0.4 1 23 293 315 293 315 0.98
7 11 3.1e-06 0.00021 22.0 2.4 1 23 321 344 321 344 0.97
8 11 9.5 6.3e+02 1.6 0.5 6 20 351 365 349 368 0.88
9 11 0.068 4.6 8.4 0.3 2 23 375 397 374 397 0.93
10 11 0.047 3.2 8.9 0.3 1 23 403 428 403 428 0.96
11 11 0.00066 0.044 14.7 0.9 1 23 434 457 434 457 0.92

Sequence Information

Coding Sequence
ATGAATTACGAACTATGCCGGCTTTGCTACGAAAAGGAGGCAAACTCAAGCATTTTTCTAAATGAAGAAGACAGTCGCACCTTTACCAAAATTGTGTACTGTTGCAAATCTATAAGTTTGCAAGAAAATGATGGTCTCCCGGATAAAATATGCAGCAGCTGCGACCGAGAGCTTGAACTTAGCTACCAATTCCTGCTCAAGTGTGAGGAGTCTGATAGGAAGCTCAGATCAATACTTACAGAAACACTTGTCTCGACTGCTGATATCCCAAAAACTGAGGTCAAAAGTGAAGATATTGATGATGGCCATCAACACACTGATGACTTGTTCTTATTCACTGACTTTAAATCAGATTCACCACTATCTGAAAAGGAGGCAGCACATACTGAAGACAACGTCAGCATTCAAAGAAGGCACAAAAAGAGGGTGAGGTTCAAAAAGGAAAATCGTGATTGCTCAGTGTGCGCTAGGAAATGTCCGAGCGCCTCCGCACTCGCCGTACACATGCGTATCCACACGAATGAAAAGCCATACCAGTGCCCATCCTGTGTCAAAAAGTATAAGGATAGCGGGACATTGAAACGCCATATTGAGAGAAATCACTTGCAGCACCGAGAGAGGCGTTTCATTTGTGAGAACTGCGGAAAAGGATTCTACTCCAAAAGTGATATAACAATCCATATGAGGGTGCATACAGGAGAAACCCCATATTCTTGTTCCGTTTGTTTCACAAGATTCACACAGCTGAGTGCAATGCTGAGACATAAGAAACGCCACACCGGAGCAAAGACCCACGTCTGTTCCACTTGCGGCAAGCTGTTCTGGACCAAAGAAGAGCTGAAGAAACACTACAGTGTCCACAACGATGTTAGGAACTTTGAATGCCCGATTTGCAATGTGCAGTTTAAGCAGAAGAGTAATATAAAGAAGCACATGGCTATCCACGCTGACCCTAACAGATATGTGTGCAACCACTGCGGACAAACATTCAACTTGAAAGGGAACCTTAAATCACACATCAGCAGGAAACATTCAGAGAAATCTGGCTCTTGTAGCATATGTTGCAAAAACGTGTCAAACATAGAAATTCACATGTGGAGGCATACAGGACAGAGGCCTCTGAAGTGTGAATTCTGCCCGAGCAGCTTCTATGAATTGAAGGCTTTGGCCCTTCATATAAACTTCAAGCACAAGAAGACAGACAGGTTCAAATGTACCATGGAAGGTTGCACCCAGGGTTTCCCTTCCAAGCCTATGATGATGTACCACATAGCGAGGTTCCATGACATGCAGACTCCATACCCTTGTGACAGGTGCTCACGAGGCTTCTACAGGAAGAATGACCTCTCCAGACATAAAATAGGCACTCATAAGGAAAGACTGCtctag
Protein Sequence
MNYELCRLCYEKEANSSIFLNEEDSRTFTKIVYCCKSISLQENDGLPDKICSSCDRELELSYQFLLKCEESDRKLRSILTETLVSTADIPKTEVKSEDIDDGHQHTDDLFLFTDFKSDSPLSEKEAAHTEDNVSIQRRHKKRVRFKKENRDCSVCARKCPSASALAVHMRIHTNEKPYQCPSCVKKYKDSGTLKRHIERNHLQHRERRFICENCGKGFYSKSDITIHMRVHTGETPYSCSVCFTRFTQLSAMLRHKKRHTGAKTHVCSTCGKLFWTKEELKKHYSVHNDVRNFECPICNVQFKQKSNIKKHMAIHADPNRYVCNHCGQTFNLKGNLKSHISRKHSEKSGSCSICCKNVSNIEIHMWRHTGQRPLKCEFCPSSFYELKALALHINFKHKKTDRFKCTMEGCTQGFPSKPMMMYHIARFHDMQTPYPCDRCSRGFYRKNDLSRHKIGTHKERLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00661578;
90% Identity
iTF_00661578;
80% Identity
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