Eram029123.1
Basic Information
- Insect
- Epinotia ramella
- Gene Symbol
- PAX1
- Assembly
- GCA_947578815.1
- Location
- OX388218.1:552265-561737[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 6 1.8e-14 5.3e-11 43.5 0.1 3 38 29 64 27 78 0.90 2 6 1.1e-13 3.1e-10 41.0 0.1 4 34 151 181 148 210 0.94 3 6 4.6e-14 1.4e-10 42.2 0.0 3 36 247 280 245 296 0.89 4 6 3.8e-14 1.1e-10 42.4 0.1 3 38 368 403 366 417 0.89 5 6 4.6e-14 1.4e-10 42.2 0.0 3 36 489 522 487 538 0.89 6 6 5.3e-68 1.6e-64 216.4 0.2 3 125 610 732 608 732 0.99
Sequence Information
- Coding Sequence
- ATGTTCACGGAAAGCAGTTCATGTAGTTGGCGAAATCCAAGTGGGGGTTCACTGGGTGGAGGCGTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACCGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACTGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACTGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGGAGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACTGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACTGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACTGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGGAGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGATGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACGGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGAGGCGTGTTCGTCAACGGGCGGCCGCTGCCCAACGCCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGCCCTGCGACATCAGCCGGCAGCTGCGCGTGTCGCACGGCTGCGTGTCCAAGATCCTGGCGCGCTACCACGAGACCGGCTCCATCCTGCCCGGCGCCATCGGCGGCTCCAAGCCGCGCGTCACCACGCCTAAAGTTGTGTCATACATAAAGCAACTAAAAGCGAAGGACCCCGGCATCTTCGCGTGGGAAATCCGCGACCGGCTGCTGGCGGACGGCGTGTGCGATAAGTACAACGTGCCCTCGGTGTCGTCCATCAGCCGCATCCTGCGCAACAAGCTGGGCGGCGCGCTGTACCCCGTGCCGCCGCTCTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGCCCTACGACTACTATGTTTATCTACAGATACTAACCGGAGTTGAAGCGAACATCGCGCCTCCCGGAATCAGGTGA
- Protein Sequence
- MFTESSSCSWRNPSGGSLGGGVGGSQQYGEVNQLGGVFVNGRPLPNAVRLRIVELAQLGISSGACSSTGGRCPTPCGCGSWSWRSWGSGEASTTNTGRLAAVRRGEPARGRVRQRAAAAQRRAAADRGAGAAGDQVRRALLTRGGSQQYREVNQLGGVFVNGRPLPNAVRLRIVELAQLGISWGSGEASTTNTGRLAAVLRGEPARGRVRQRAAAAQRRAAADRGAGAAGDQVRRALLTRGGSQQYCEVNQLGGVFVNGRPLPNAVRLRIVELAQLGISSEACSSTGGRCPTPCGCGSWSWRSWGSGEASTTNTGRLAAVLRGEPARGRVRQRAAAAQRRAAADRGAGAAGDQVRRALLTRGGSQQYCEVNQLGGVFVNGRPLPNAVRLRIVELAQLGISSGACSSTGGRCPTPCGCGSWSWRSWGSGEASTTNTGRLAAVRRGEPARGRVRQRAAAAQRRAAADRGAGAAGDQVRRALLTRGGSQQYCEVNQLGGVFVNGRPLPNAVRLRIVELAQLGISSEACSSTGGRCPTPCGCGSWSWRSWGSDEASTTNTGRLAAVRRGEPARGRVRQRAAAAQRRAAADRGAGAAGDQVRRALLTRGGSQQYGEVNQLGGVFVNGRPLPNAVRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVSYIKQLKAKDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKLGGALYPVPPLYPVPPQRCWPLHQPYDYYVYLQILTGVEANIAPPGIR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -