Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.025 1.8e+02 2.9 0.0 38 56 19 37 10 43 0.87

2 5 0.015 1.1e+02 3.6 0.0 38 56 82 100 58 106 0.87

3 5 0.014 1e+02 3.7 0.0 38 56 145 163 121 169 0.86

4 5 0.014 97 3.7 0.0 38 56 208 226 184 233 0.86

5 5 0.0059 41 4.9 0.0 36 57 269 290 246 296 0.82

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.025	1.8e+02	2.9	38	56	19	37	10	43	0.87
2	5	0.015	1.1e+02	3.6	38	56	82	100	58	106	0.87
3	5	0.014	1e+02	3.7	38	56	145	163	121	169	0.86
4	5	0.014	97	3.7	38	56	208	226	184	233	0.86
5	5	0.0059	41	4.9	36	57	269	290	246	296	0.82

Coding Sequence: ATGCACTTGTTGGTAACGTCTCGCACATCTCCGGAGCTGAGGCGGTACTTGTGGCGCAGGCTGCAGGACATGGCGAGCGTGTTCAGCAGCTCGAACAACGTCGTGAAATACACGAGCCCGAGCAGAGTTAGTAAGGAGCCAAGTTTCGCTGTGACCCCAGACAGCTGGTCTATTACGTATCCTGTGGTAACTCACTTGTTGGTAATATACCGGACATCTCCGGAGCTGAGGCGGTACTTGTGGCGCAGGCTGCAGGACATGGCGAGCGTGTTCAGCAGCTCGAACAGCGTCGTGAAATACACGAGCCCGAGCAGAGTTAGTAAGGAGCCAAGTTTCGCTGTGACCCCAGACAGCTGGTCTATTACGTATCCTGTGGTAACTCACTTGTTGGTAATATCCCGGACATCTCCGGAGCTGAGGCGGTACTTGTGGCGCAGGCTGCAGGACATGGCGAGCGTGTTCAGCAGCTCGAACAGCGTCGTGAAATACACGAGCCCGAGCAGAGTTAGTAAGGAGCCAAGTTTCGCTGTGACCCCAGACAGCTGGTCTATTACGTATCCTGTGGTAACTCACTTGTTGGTAATATCCCGGACATCTCCGGAGCTGAGGCGGTACTTGTGGCGCAGGCTGCAGGACATGGCGAGCGTGTTCAGCAGCTCGAACAGCGTCGTGAAATACACGAGCCCGAGCAGAGTTAGTAAGGAGCCAAGTTTCGCTGTGACCCCAGACAGCTGGTCTATTACGTATCCTGTGGTAACTCACTTGTTGGTAATATCCCGGACATCTCCGGAGCTGAGGCGGTACTTGTGCCGCAGGCTGCAGGACATGGCGAGCGTGTTCAGCAGCTCGAACAGCGTCGTGAAATACACGAACCCGAGCAGGGTTATTAACGAGCCGCGTTTCACTGTGATCCTGAAAGATACAGCTAAGTTTAAGTAA
Protein Sequence: MHLLVTSRTSPELRRYLWRRLQDMASVFSSSNNVVKYTSPSRVSKEPSFAVTPDSWSITYPVVTHLLVIYRTSPELRRYLWRRLQDMASVFSSSNSVVKYTSPSRVSKEPSFAVTPDSWSITYPVVTHLLVISRTSPELRRYLWRRLQDMASVFSSSNSVVKYTSPSRVSKEPSFAVTPDSWSITYPVVTHLLVISRTSPELRRYLWRRLQDMASVFSSSNSVVKYTSPSRVSKEPSFAVTPDSWSITYPVVTHLLVISRTSPELRRYLCRRLQDMASVFSSSNSVVKYTNPSRVINEPRFTVILKDTAKFK

Sequence clustering based on sequence similarity using MMseqs2