Basic Information

Gene Symbol
MBD3
Assembly
GCA_932294385.1
Location
CAKOAM010000011.1:3067687-3076651[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1.5e-27 4.7e-24 84.3 0.1 1 72 5 71 5 75 0.95
2 3 0.0014 4.5 7.4 0.0 29 73 93 145 79 148 0.84
3 3 1.7 5.2e+03 -2.4 0.1 7 23 295 311 292 315 0.81

Sequence Information

Coding Sequence
ATGAATATTTCAATCGAAAAGAAACGTTCAGAGTGTCCTGCACTGCCTAAAGGCTGGCAAAGAGAAGAAGTTCTTAGAAAAACTGGGTTATCGGCAGGGAAGGTTGATGTTTATTACTATAGCCCAACAGGTAAAAAGTTTCGCAGTAAGCCTGAGCTAGTGCGTTATCTGGGTGATAGTATGGACCTATCGTGTTTCGACTTCCATCAGGGTCAGATAAACACAATGTTGCTGTGCAAGGCCAAGAAAGCGCGAGCGCAGTTTGATTACAGAGGTGTTCGTTCAGACGCATCGCTGGTGCCGCCAATCCGACAAACGGCTTCGATATTCAAACAACCGGTGACGGTGTATAAGACTCAGGAGAGTATGGTGAAGACGGATCTGAAGCACGGCACCACGGAGAAACCCAAGCAGCTGTTCTGGGAGAAGAGGTTGGAGGGTTTAACCGCCTGCGACGCCAACGGAGTGATCGGCACGACGTCGCTGCCCAAGTACATCAAGCCCCTAGGCCCGTACAATTCGGACGCCACCACAATCCAGTCGCTCGCCACTGCGCTGCACGTTTCATCGCAGTCCATTACTGGCCAGACCGGTTCCAAACACGCGATTCTGGAGAATCCGGGCGTTTTTTTAAACCCTGAGCAGCCGCTGATCGCGGCCGTGACCATTAGCAAGGAGGACGTGCGCCGCCAGGAGGACCGCGTGAAGCGAGCGCGCGCGCGTTTGCAGGTGGGTTCACAACGATACCTGCGCAAGTGGTGGGTGCGAGGCGCTAGCGGCGGCGTAGCGCGGCGCCGGCGCGGCCGCGCCCGCGCCCCCCGCAGCCCCCGGCCCGGCCTCGCCCGCCGCCGCGGCGCCCGACCAGTCGCACCACGCCGCGCCCGCCTCCAGCCCGCACCACCCGGAGGCCGGCGTGCACTCTACCACCGACTAGGCATGCCCCGCCCGCGCCCCCCGCAGCCCCCGGCCCGGCCTCGCCCGCCGCCGCGGCGCCCGACCAGTCGCACCACGCCGCGCCCGCCTCCAGCCCGCACCACCCGGAGGCCGGCGTGCACTCTACCACCGACTAGGCATGCCCCGCCCGCGCCCCCCGCAGCCCCCGGCCCGGCCTCGCCCGCCGCCGCGGCGCCCGACCAGTCGCACCACGCCGCGCCCGCCTCCAGCCCGCACCACCCGGAGGCCGGCGTGCACTCTACCACCGACTAG
Protein Sequence
MNISIEKKRSECPALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKFRSKPELVRYLGDSMDLSCFDFHQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESMVKTDLKHGTTEKPKQLFWEKRLEGLTACDANGVIGTTSLPKYIKPLGPYNSDATTIQSLATALHVSSQSITGQTGSKHAILENPGVFLNPEQPLIAAVTISKEDVRRQEDRVKRARARLQVGSQRYLRKWWVRGASGGVARRRRGRARAPRSPRPGLARRRGARPVAPRRARLQPAPPGGRRALYHRLGMPRPRPPQPPARPRPPPRRPTSRTTPRPPPARTTRRPACTLPPTRHAPPAPPAAPGPASPAAAAPDQSHHAAPASSPHHPEAGVHSTTD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-