Enis020830.1
Basic Information
- Insect
- Epinotia nisella
- Gene Symbol
- PAX1
- Assembly
- GCA_932294385.1
- Location
- CAKOAM010000125.1:646608-664684[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 12 1.7 3.5e+03 -1.6 0.1 19 72 17 72 13 76 0.75 2 12 1.7e-14 3.6e-11 43.6 0.1 3 39 124 160 122 175 0.88 3 12 5.3e-10 1.1e-06 29.0 0.1 3 29 245 271 243 276 0.89 4 12 1.7e-14 3.6e-11 43.6 0.1 3 39 278 314 274 329 0.88 5 12 4.5e-14 9.3e-11 42.2 0.1 3 35 399 431 397 435 0.93 6 12 4.2e-14 8.9e-11 42.3 0.1 3 35 436 468 432 472 0.93 7 12 4.3e-14 9.1e-11 42.2 0.1 3 35 473 505 470 509 0.93 8 12 4.5e-14 9.3e-11 42.2 0.1 3 35 510 542 508 546 0.93 9 12 1.7e-14 3.6e-11 43.5 0.1 3 39 547 583 544 598 0.88 10 12 4.4e-14 9.3e-11 42.2 0.1 3 35 668 700 666 704 0.93 11 12 5.1e-10 1.1e-06 29.1 0.1 3 29 705 731 703 737 0.89 12 12 6.1e-68 1.3e-64 216.2 0.2 3 125 738 860 734 860 0.99
Sequence Information
- Coding Sequence
- ATGGCGGCAAACACCGCCCCCCGCCCCGCCCCGCCCCGCCGCGTCGCCCCCGCGGCTACCGGCGCCCGCGCAGCCTCGAGTGCTGCTCAAGAGGTAGTACCACTCCAAGTGGCCGTGCGCATACGCATCGCTCCCGTATGTTTGCGGGCGCGGTGGCTGTTTGCGCGCGGCGCGATTGTCGGCGGCCTGTCGCCGCGGGCGGTCCACGCAAACAAACGGCACTCTAAGCTCTTCATAGAAGGAGTGGACTCGGGCTGGACCAAAAAACTCTGGAAATCCAGCAGGAAGCAACTCAGAATTATATCTGGGGTGTTCACAGATCCAAGTGGAGGTTCACTGGGCGGCGGCGTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGAGGCGAGCACTACTAACACTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGGTGAGGCGAGCACTACTAACACTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCGCAGCTGGGGATCAGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGAGGCGAGCACTACTAACACTGGGCGGCTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGGGGCGTGTTCGTCAACGGCCGGCCGCTGCCCAACACCGTGCGGCTGCGGATCGTGGAGCTGGCCCAGCTGGGGATCAGGCCCTGCGACATCAGCCGGCAGCTACGCGTGTCGCACGGCTGCGTGTCCAAGATCCTGGCGCGCTACCACGAGACCGGCTCCATCCTGCCCGGCGCCATCGGGGGCTCCAAGCCGCGTGTCACCACACCCAAGGTGGTGTCATACATAAAGCAGCTAAAAGCGAAAGATCCCGGCATTTTCGCGTGGGAGATCCGCGACCGGCTGCTGGCGGACGGCGTCTGCGACAAGTACAACGTGCCCTCCGTGTCGTCCATCAGCCGTATCCTGCGCAACAAGTTGGGCGGCGCACTCTACCCCGTGCCGCCGCTCTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCATCAGCCCTATGACTACTATGTTTATCTACAGGGCCGGCAGCACGCGGGCGGCGCGGCGCACGCGCACGCGCTGCACCCGCACCAGCAGCCGGCGCCGCCGCACCACGCGCACGCGCTCTGA
- Protein Sequence
- MAANTAPRPAPPRRVAPAATGARAASSAAQEVVPLQVAVRIRIAPVCLRARWLFARGAIVGGLSPRAVHANKRHSKLFIEGVDSGWTKKLWKSSRKQLRIISGVFTDPSGGSLGGGVGGSQQYGEVNQLGGVFVNGRPLPNTVRLRIVELAQLGISSGACSSTAGRCPTPCGCGSWSWRSWGSGEASTTNTGRLAAVRRGEPARGRVRQRPAAAQHRAAADRGAGAAGDQVRRALLTLGGSQQYGEVNQLGGVFVNGRPLPNTVRRALLTLGGSQQYGEVNQLGGVFVNGRPLPNTVRLRIVELAQLGISSGACSSTAGRCPTPCGCGSWSWRSWGSGEASTTNTGRLAAVRRGEPARGRVRQRPAAAQHRAAADRGAGAAGDQVRRALLTLGGSQQYGEVNQLGGVFVNGRPLPNTVRLRIVELAQLGISSQQYGEVNQLGGVFVNGRPLPNTVRLRIVELAQLGISSQQYGEVNQLGGVFVNGRPLPNTVRLRIVELAQLGISSQQYGEVNQLGGVFVNGRPLPNTVRLRIVELAQLGISSQQYGEVNQLGGVFVNGRPLPNTVRLRIVELAQLGISSGACSSTAGRCPTPCGCGSWSWRSWGSGEASTTNTGRLAAVRRGEPARGRVRQRPAAAQHRAAADRGAGAAGDQVRRALLTLGGSQQYGEVNQLGGVFVNGRPLPNTVRLRIVELAQLGISSQQYGEVNQLGGVFVNGRPLPNTVRRALLTLGGSQQYGEVNQLGGVFVNGRPLPNTVRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVSYIKQLKAKDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKLGGALYPVPPLYPVPPQRCWPLHQPYDYYVYLQGRQHAGGAAHAHALHPHQQPAPPHHAHAL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -