Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4e-39 4.6e-36 123.3 0.2 2 84 59 140 58 144 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4e-39	4.6e-36	123.3	0.2	2	84	59	140	58	144	0.96

Coding Sequence: ATGAGCGACTCGCCCGGGGTGGAATGGCTGCCGGCGTACAGCCCCGGGCCGCCGCGGCACAGCCCGCTGGGCCCGATCCCGCGCTTCCTGTTCGAGGGCGTGCAGCCGCTGGGGCTGCTGGAGAACAACAACAAGGAGGCTGATCAGAAGGAGAACGCCAAGATCAAGCACGCTAAACCCGCCTACAGCTATGCCAGCATGATCCGACTGGCCATCAGCAGCTCACCCAACGGCAAGATGACACTAAACGAAATCTACACATACATCTGTAATGCTTTTCCTTACTATAGGGAGGCTGGCAAGGGATGGATGAACTCTATCCGACACAACTTGTCACTTAACAAATGCTTCATGAAAGTGGCCCGGAGCAAAGATGACCCGGGCAAGGGCTCATACTGGGCCATGGACAGCAGCTACAAATTGTCCGAGGTTACGCCGCGCCGACGCCGCTCATTGCGGATGGCGCCGTACAGCCCGGAGTGCAGTTCCAACAGCAGCGGCGAGGCGGCCGGCCTGGCGCCCGACGCGGCGCCCACGCCGCCCGCCACGCCCACCGACCGCGCGCCCGAGCCCGCGCCCTGCGACGCCCCGGCACAGGACACGAGGACGCCAGAATCAAAACACACAGACGACGCGCTGACGGCGCTTATGAACGAGGAGCTCATAGCAGACGTGGACATCGGTGAAGAGCGGTCCCGGTGCTCCGGGCGGCGGCACGTGTGCTGCACGCTGCTGACGGCGCTCACGGACGACTACGGCAACTTCGTGGTGAGCGACGACTGCGACTGCCCCCCCGCCGACCCCGCGCCCGCCACGCCCCCGCCGCCCGCGCCGCTCTACTGGCCCGCCGACTTATAA
Protein Sequence: MSDSPGVEWLPAYSPGPPRHSPLGPIPRFLFEGVQPLGLLENNNKEADQKENAKIKHAKPAYSYASMIRLAISSSPNGKMTLNEIYTYICNAFPYYREAGKGWMNSIRHNLSLNKCFMKVARSKDDPGKGSYWAMDSSYKLSEVTPRRRRSLRMAPYSPECSSNSSGEAAGLAPDAAPTPPATPTDRAPEPAPCDAPAQDTRTPESKHTDDALTALMNEELIADVDIGEERSRCSGRRHVCCTLLTALTDDYGNFVVSDDCDCPPADPAPATPPPPAPLYWPADL

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00655908; iTF_00660122; iTF_00656957; iTF_00411234; iTF_00148300; iTF_00289441; iTF_01072263; iTF_00871112; iTF_00412335; iTF_00409101;
90% Identity: iTF_01072263; iTF_00656957; iTF_00655908; iTF_00660122;
80% Identity: -