Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0013 8.4 8.1 2.7 26 54 16 46 11 49 0.65

2 5 0.0013 8.4 8.1 2.7 26 54 68 98 63 101 0.65

3 5 0.00012 0.76 11.4 4.2 26 60 120 156 115 168 0.75

4 5 0.00014 0.9 11.2 4.6 25 60 173 210 162 218 0.76

5 5 0.0002 1.3 10.7 0.4 24 56 226 260 220 272 0.66

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0013	8.4	8.1	2.7	26	54	16	46	11	49	0.65
2	5	0.0013	8.4	8.1	2.7	26	54	68	98	63	101	0.65
3	5	0.00012	0.76	11.4	4.2	26	60	120	156	115	168	0.75
4	5	0.00014	0.9	11.2	4.6	25	60	173	210	162	218	0.76
5	5	0.0002	1.3	10.7	0.4	24	56	226	260	220	272	0.66

Coding Sequence: ATGGGTCGCGGCGGTGGCGTGCAGAGCGGGCGCCCGCCCTCGCAGGCGGCGTACTTCGTGGCGCTCGCTGTCATAGCGCTGCTGCTGCTCATGCTGTGCTGCTACTTCCTCTACTTCTGCGTCAAGAAGATTAACGACAGATGGTGTGAGGGGAGCAAAATAGTTCGCGGTGGCGTGCCGAGCGGGCGCCCGCCCTCGCAGGCGGCGTACTTCGTGGCGCTCGCTGTCATAGCGCTGCTGCTGCTTATGCTGTGCTGCTACTTCCTCTACTTCTGCGTCAAGAAGATTAACGACAGATGGTGTGAGGGGAGCAAAATAGTTCGCGGTGGCGTGCCGAGCGGGCGCCCGCCCTCGCAGGCGGCGTACTTCGTGGCGCTCGCTGTCATAGCGCTGCTGCTGCTTATGCTGTGCTGCTACTTCCTCTACTTCTGCGTCAAGAAGATTAACGACACAGACAGATGGTGTGAGGGGAGCAAAATAGTTCGCTGTGGCGTGCAGAGCGGGAGCCCGCCCTCGCAGGCGGCGTACTTCGTGGCGCTCGCTGTCATAGCGCTGCTGCTGCTCATGCTGTGCTGCTACTTCCTCTACTTCTGCGTCAAGAAGATTAACGACACAGACAGATGGTGTGAGGGGAGCAAAATAGTTCGCTGTGGCGTGCAGAGCGGGCACCCGCCCTCGCAGGCGGCGTACTTCGTGGCGCTCGCTGTCATAGCGCTGCTGCTGCTCATGCTGTGCTGCTACTTCCTCTACTTCTGCGTCAAGAAGATTAACGAGTTGTCAGAGCGCGAGTCGCTGTGCGGCGCGTCAGCCTCTCGCGCGCAGCCGGCTCCCGCCAGGGACGCCTACCCCGTGCAACCAGTGGTAAGAGAGAGCGCCACAGCAATAGCGAAGATGTGCAAGGAGCTGCCGAGCGGCGCGCGGGGCGTCGTGTTCCCCGCGGCGACGTCGCCGGCCGCGCTGCTCGCCGACACGGGCGCGGGCGGCTCGCTCGCCTCGGGCAGCGACGGTGCCACGCTCAGCGATGACACCGCCACTACGGGTGCCAGCGAGGAAGCCGCGCCTGGGGCACGCAGGTAA
Protein Sequence: MGRGGGVQSGRPPSQAAYFVALAVIALLLLMLCCYFLYFCVKKINDRWCEGSKIVRGGVPSGRPPSQAAYFVALAVIALLLLMLCCYFLYFCVKKINDRWCEGSKIVRGGVPSGRPPSQAAYFVALAVIALLLLMLCCYFLYFCVKKINDTDRWCEGSKIVRCGVQSGSPPSQAAYFVALAVIALLLLMLCCYFLYFCVKKINDTDRWCEGSKIVRCGVQSGHPPSQAAYFVALAVIALLLLMLCCYFLYFCVKKINELSERESLCGASASRAQPAPARDAYPVQPVVRESATAIAKMCKELPSGARGVVFPAATSPAALLADTGAGGSLASGSDGATLSDDTATTGASEEAAPGARR

Sequence clustering based on sequence similarity using MMseqs2