Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.037 2.8e+02 3.2 0.1 21 43 30 52 24 57 0.87

2 9 0.00042 3.1 9.5 0.0 21 46 58 83 53 90 0.86

3 9 0.26 1.9e+03 0.5 0.1 22 47 87 111 84 114 0.78

4 9 0.032 2.3e+02 3.5 0.2 18 43 111 136 103 141 0.86

5 9 0.068 5e+02 2.4 0.1 21 44 142 165 136 173 0.84

6 9 0.00037 2.8 9.6 0.3 20 45 197 222 190 229 0.85

7 9 0.038 2.8e+02 3.2 0.1 21 49 226 254 221 258 0.82

8 9 0.023 1.7e+02 3.9 0.2 22 50 256 284 247 287 0.81

9 9 0.011 81 4.9 0.0 23 44 285 306 279 313 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.037	2.8e+02	3.2	0.1	21	43	30	52	24	57	0.87
2	9	0.00042	3.1	9.5	0.0	21	46	58	83	53	90	0.86
3	9	0.26	1.9e+03	0.5	0.1	22	47	87	111	84	114	0.78
4	9	0.032	2.3e+02	3.5	0.2	18	43	111	136	103	141	0.86
5	9	0.068	5e+02	2.4	0.1	21	44	142	165	136	173	0.84
6	9	0.00037	2.8	9.6	0.3	20	45	197	222	190	229	0.85
7	9	0.038	2.8e+02	3.2	0.1	21	49	226	254	221	258	0.82
8	9	0.023	1.7e+02	3.9	0.2	22	50	256	284	247	287	0.81
9	9	0.011	81	4.9	0.0	23	44	285	306	279	313	0.88

Coding Sequence: ATGGACGAGCCTGCGGGGGAGAGCGAGACCGCGCACGAGGGCGACGAGTCCCAAGAGACAGGAATGGACTCGGCGCCCGCGACCACGGCAGAAAAACCCTACAGCTGCGATGTGTGTCCAAAACATTTCACACTTCTGCACGATTTAAGGCGACATGAGCGAATTCACTCGGGGGAGAAACCGTTCACGTGTGACATCTGCAATAAGACATTTACCCAGTCCGGCGCGGTGAAGCTGCACATGCGCATACACACCGGAGAAAGACCTTACCCCTGCGGCATTTGCGAAAAACGATTCACGCAACTGGGCCAGTTGAAGGTGCACGAGCGCCGGCACACGGGGGAGAAACCGTACGCCTGCAATGTATGCGACAAGCGGTTCACGCGCTCGCATGATCTACAGTCACACGAGCGCACTCACACCGGAGAAAAACCTTATGCGTGTGATTTGTGTGAAAAACAGTTTGCACAATCAAGTGCGCTAGTAATGCACAAACGCAACGTTCACACGAGCGAGACATACCGCTGTAAACTATGCATCAGGAAGTTCACAGAACTAGACGCTTTAAAGGAACACGAGCGGGTGCACACGAGCGAAAAGAGATTCTCCtgtgaaatatgtaaaaaaaacttcaGACAATCGTGCCAGTTGACTAAACACATGCGGAGCCACACGGGGGAGAAACCCTATACCTGTGAGACGTGCGACAAGGAGTTCGCGCGTCTTGACTATTTGAAACGACACGAGCGGATAGTGCACATGGGAGAAAAAAGATACTGTTGCCAGGTCTGTAAGAAAGAGTTCACGGGCTCCGGGAACCTGAGGAAACACGAGCGAATCCATACTGGTGTCAAACCATACTCGTGCGATATCTGTAACAAAGTGTTCGGCGCCTCCGGCAGTCTGAAGAAGCATAAACTAATGCACGCTAAAGAAGCGAACAAGGCGCGGAGCGGGGACGAGTGCACCTAA
Protein Sequence: MDEPAGESETAHEGDESQETGMDSAPATTAEKPYSCDVCPKHFTLLHDLRRHERIHSGEKPFTCDICNKTFTQSGAVKLHMRIHTGERPYPCGICEKRFTQLGQLKVHERRHTGEKPYACNVCDKRFTRSHDLQSHERTHTGEKPYACDLCEKQFAQSSALVMHKRNVHTSETYRCKLCIRKFTELDALKEHERVHTSEKRFSCEICKKNFRQSCQLTKHMRSHTGEKPYTCETCDKEFARLDYLKRHERIVHMGEKRYCCQVCKKEFTGSGNLRKHERIHTGVKPYSCDICNKVFGASGSLKKHKLMHAKEANKARSGDECT

Sequence clustering based on sequence similarity using MMseqs2