Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00022 2.8 10.1 0.1 22 44 12 34 6 40 0.88

2 6 0.034 4.3e+02 3.1 0.4 22 43 40 61 36 70 0.82

3 6 0.23 2.9e+03 0.5 0.1 17 36 63 82 50 98 0.66

4 6 0.021 2.7e+02 3.8 0.2 21 44 95 118 87 127 0.83

5 6 1.2e-06 0.014 17.4 0.1 23 51 125 153 120 155 0.91

6 6 0.51 6.4e+03 -0.6 0.0 26 45 173 192 166 193 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00022	2.8	10.1	0.1	22	44	12	34	6	40	0.88
2	6	0.034	4.3e+02	3.1	0.4	22	43	40	61	36	70	0.82
3	6	0.23	2.9e+03	0.5	0.1	17	36	63	82	50	98	0.66
4	6	0.021	2.7e+02	3.8	0.2	21	44	95	118	87	127	0.83
5	6	1.2e-06	0.014	17.4	0.1	23	51	125	153	120	155	0.91
6	6	0.51	6.4e+03	-0.6	0.0	26	45	173	192	166	193	0.87

Coding Sequence: ATGGCGATGGTGGCTCACCTGCGGAAACACAAGAGGCCGCCAGCGACATGCCACGTGTGTGACAAGACCTTCCAATATGAgcacaatttaaaaaaacatatgatCACACATTCCAAAGAGCGGAGCTTCACATGTAACATTTGCCAGAAAGCGTACAAGCATATGTCTTCGTTGAGAGTTCATAAATGCAATAAAGCGAGCGAGAAACCGTTCAAATGCGAACATTGTCCGAAAAGCTTCTCTTTCAAAGGCCAGTTGCAAACGCACACCAGGTTACACACTGGAGAGAAACCATATAAGTGCAATATATGTTCTAAAGAATTCACGCAGCAGACGTCTTTGAATAACCATGCTTTGAAACATGAAGGCATTAAGCCGCACCGCTGTGAGTTCTGCAAGGAAAAGTTCCGTCAAGTCAGCAATTTGAAGAAGCATTTGGAGATAAAACATTCAGATAAAAAGGTTGAATGTCATCAGAAAACTCGGAAGCTTTTGAGCATTTCCTTAGTGTGGTATTCTTGTAAGAACTGTCGAATTGTGTTCTCAGGGAGTGATAGAATTAAGAAACATTTGAAAACATGTAACTGA
Protein Sequence: MAMVAHLRKHKRPPATCHVCDKTFQYEHNLKKHMITHSKERSFTCNICQKAYKHMSSLRVHKCNKASEKPFKCEHCPKSFSFKGQLQTHTRLHTGEKPYKCNICSKEFTQQTSLNNHALKHEGIKPHRCEFCKEKFRQVSNLKKHLEIKHSDKKVECHQKTRKLLSISLVWYSCKNCRIVFSGSDRIKKHLKTCN

Sequence clustering based on sequence similarity using MMseqs2