Basic Information

Gene Symbol
-
Assembly
GCA_963854355.1
Location
OY977953.1:12381022-12397769[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.00015 0.02 17.3 0.1 3 23 125 145 124 145 0.97
2 18 1.4e-06 0.00018 23.8 1.2 1 23 151 173 151 173 0.99
3 18 8.6e-06 0.0011 21.3 2.7 1 23 179 201 179 201 0.99
4 18 1.3e-06 0.00016 23.9 1.3 1 23 216 238 216 238 0.98
5 18 0.00017 0.022 17.2 0.7 1 23 253 275 253 275 0.98
6 18 7.9e-05 0.01 18.2 3.1 1 23 290 312 290 312 0.98
7 18 9.8e-07 0.00013 24.2 1.5 1 23 327 349 327 349 0.99
8 18 9.4e-05 0.012 18.0 0.0 1 23 356 378 356 378 0.99
9 18 1.7e-05 0.0022 20.3 2.1 1 23 384 406 384 406 0.99
10 18 0.23 30 7.3 1.8 1 23 413 435 413 435 0.98
11 18 9.3e-07 0.00012 24.3 2.3 1 23 441 463 441 463 0.99
12 18 0.064 8.2 9.1 1.8 1 23 470 492 470 492 0.98
13 18 3.8e-06 0.00048 22.4 1.5 1 23 498 520 498 520 0.99
14 18 0.00072 0.092 15.2 0.7 1 23 527 549 527 549 0.99
15 18 4.2e-06 0.00053 22.2 1.9 1 23 555 577 555 577 0.98
16 18 0.0031 0.39 13.2 0.3 1 20 583 602 583 605 0.93
17 18 0.00016 0.02 17.3 0.9 2 23 612 633 611 633 0.96
18 18 5.4e-06 0.00069 21.9 1.4 1 23 639 662 639 662 0.97

Sequence Information

Coding Sequence
ATGTTCGAGCAGCAGATCAAGGCTGAACCTATGAGCTTCTACACATCACACGCCCACGTCCACTCCGCGCCCACGATAGTCCGCTCCGACTCAGCCCACATCATCAACATGAACCAGCATCACCCGGAAGACTCCAAGGACAGCCTCATCATACAGCAACAGGTTCATCAGCAGGATCTGATGGACCACCAGCAGCAGGACTTGCAGCAGGATGATGAGttAAGCTTTAAAGGAATGGATGACGAGGGAGTCGAAATGGATATGGATGGTCGCCAATGCTCTCAGGGCTTGGGCGTCGATATGGGTTCAGTTCAAACAAAAATGGAGATATCAAATGGAGGTCAATCAACACCACGTTCCAAACCGCAGGCCTGTAAGGTTTGCGGTAAGGTACTCTCGTCCGCTTCGTCTTATTACGTCCATATGAAGCTTCATTCCGGAAACAAGCCTTTTCAGTGTACGGTTTGCGACGCAGCATTCTGCCGCAAACCGTATCTGGAAGTCCACATGCGCACGCACACGGGCGAGAGGCCTTTCCAGTGTGACCTCTGCCTCAAACGCTTCACACAGAAGTCCAGTCTCAACACGCACAAGCGCGTTCACACCGATGAGCACATGCGCGCCTTGATGGTGAAGGAGCGGCCCTACAGGTGCGAGCTCTGTGGCGTCCGGTTCACGCAGAGCTCCAGCCTCAACCGCCACAAGAAAATACACACGGAGGAACACAGACGCGCGCTGCTGGCTAAGGAACGCCCCTACCAATGCGGCGTCTGCTATCTGAGATTCACGCAGAAATCGAGTTTGGGCCGGCACGGAAAAATACATACCGAGGAGCACAGACGAGCCCTGTTAGAGAAAGTGCGGCCGTACCAGTGCCACATCTGTTTTATGCGCTTCACTCAGAAGTCCAGCCTGGGCCGACATGGGAAAATACATACTGAGGAGCACATCCAATCGCTGATCAACAAAGTGCGCCCGTATCAGTGCGACGTCTGTGACAAGCGGTTCACGCAGAAGTCGAGCCTGGGCACTCATAAACGTATACACACTGTGCAAGGGCGCCCTTACACGTGCGGGCTTTGCCCGGCGGCCTTCGCCCGCCGCCCCTACCTGGACATTCACAtgcgcacgcacacaggcgaGCGGCCCTATCAGTGCGACGCCTGTCTCAAGCGCTTCACGCAGAAGTCCAGCCTCAATATACATAAGCGGACGCACACAGTCCAGGGCAGACCGTTCCAGTGCCTGTCGTGTCCGGCCGCCTTCACGTGCAAGCAGTACCTGGAGATCCACAACCGCACGCACACGGGCGAGCGGCCTTATCAGTGCGACATCTGCCTCAAGCGGTTCACGCAGAAATCCAGCCTCAACATCCACAAGCGGACGCACTCAGTGCAGGGCCGGCCGTTCCAGTGTCTGCAGTGTCCGGCCGCCTTCACGTGCAAGCAGTACCTGGAGATCCACAACCGCACGCACACGGGCGAGCGGCCGTACCAGTGTGACGTGTGCCTGAAGAGATTCGCGCAAAAGTCCACACTCAACATACACAAACGAACGCACACGGTGCAAGGTCGGCCGTACCAATGCATGGAGTGCCCGGCCGCGTTCACTTGCAAGCCGTACTTGGAGATCCACATGAGGACTCACACCGGCGAGAGGCCGTTTGAGTGCGATGTCTGTTACAAGCGCTTCACGCAGAAATCGACGCTCAACATTCACAAGCGAATTCACAccggggAACGGCCATATGCCTGTGACATATGTCAGAAACGATTCGCTGTGAAGAGCTACGTAACAGCACACAGATGGTCGCACGTGGCCGACAAGCCGCTGAACTGCGACCGCTGCTCGATGACCTTCACGTCCAAGGCGCAGTTCGCGCTGCACATCCGCACGCACACGGCCGGCTCCTGCTACGAGTGCAGCGTGTGCGGACGCACTTTCGTCAGGGACAGCTATCTAATACGACACCACAATCGCGTGCACCGCGAGAACCACAGCAACGTGTCGGCGAACAGCATGGGAACCATAAACAGCGTCGCGACCAACACTAATAATTCGAACAACAGCAACTTTGACTCGCCTGGCGTTTGTGACTTAAGGTACGTGCACTTGTAA
Protein Sequence
MFEQQIKAEPMSFYTSHAHVHSAPTIVRSDSAHIINMNQHHPEDSKDSLIIQQQVHQQDLMDHQQQDLQQDDELSFKGMDDEGVEMDMDGRQCSQGLGVDMGSVQTKMEISNGGQSTPRSKPQACKVCGKVLSSASSYYVHMKLHSGNKPFQCTVCDAAFCRKPYLEVHMRTHTGERPFQCDLCLKRFTQKSSLNTHKRVHTDEHMRALMVKERPYRCELCGVRFTQSSSLNRHKKIHTEEHRRALLAKERPYQCGVCYLRFTQKSSLGRHGKIHTEEHRRALLEKVRPYQCHICFMRFTQKSSLGRHGKIHTEEHIQSLINKVRPYQCDVCDKRFTQKSSLGTHKRIHTVQGRPYTCGLCPAAFARRPYLDIHMRTHTGERPYQCDACLKRFTQKSSLNIHKRTHTVQGRPFQCLSCPAAFTCKQYLEIHNRTHTGERPYQCDICLKRFTQKSSLNIHKRTHSVQGRPFQCLQCPAAFTCKQYLEIHNRTHTGERPYQCDVCLKRFAQKSTLNIHKRTHTVQGRPYQCMECPAAFTCKPYLEIHMRTHTGERPFECDVCYKRFTQKSTLNIHKRIHTGERPYACDICQKRFAVKSYVTAHRWSHVADKPLNCDRCSMTFTSKAQFALHIRTHTAGSCYECSVCGRTFVRDSYLIRHHNRVHRENHSNVSANSMGTINSVATNTNNSNNSNFDSPGVCDLRYVHL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00010401;
90% Identity
iTF_00022996;
80% Identity
-