Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.2 9.7e+03 -1.7 0.0 5 16 32 43 29 45 0.83

2 3 1.1 9.1e+03 -1.6 0.2 13 20 172 179 166 187 0.84

3 3 2.8e-09 2.3e-05 25.9 0.0 32 75 266 307 227 309 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.2	9.7e+03	-1.7	0.0	5	16	32	43	29	45	0.83
2	3	1.1	9.1e+03	-1.6	0.2	13	20	172	179	166	187	0.84
3	3	2.8e-09	2.3e-05	25.9	0.0	32	75	266	307	227	309	0.90

Coding Sequence: ATGACAATCAAGCCCCACAAGATGGCGTCACACACGTGTGGCCCCCGCTGCAAGCGCACCGACGTGCTCGCACTCAAGGACTTGAGGACTTACAACCCACTTACCAAGCCGCTGCTCAGCGGGTGGGAGAGCTTGTCTGCCGATGCTGCTATTATGTGCCTTTGTCGGTTTATCGCCAAAAGAGGGACACCAAGCCAGATATACTCCGATAACGGCCTGCCTACGTCGGTGCAAACAGACAGTTACGCGCACTTTATGATGAAGCCGTCGCTGATTATGCCACTAACAAAGAAATTGAATGGATTTTCATTCCCGCCTCCGCACCTTACATGGGACGAAGTGCTTACCACACTCTTGGCCGAAGCAGAAGCACTCGTAAACGCACGtcccctcacacacgtgtcgCCCGACGCTGCTGACCCTGAGGCCCTTACACCATGTCACCTACTGCTGGGATCTTCCTCTGGTCGCCCGATACCCGCCCAGCTCACGGACTCAGACCTCTGCAGCAGGAGCGGATGGCGCAGAGCTCTGAGGCTTGCAGATCATTTCTGGCGCCGCTGGGTTATTGAATACTTGCCAACCCTTGCCCCGCGCCGTGTCAGAGGCCTCCCGACTCCAACCATTTCGATCGGAGACCCTGTACTCATTGCTGATGGAGACCTACCGAGAGGCACGTGGCCACGAGGCGTAGTTTCGCGTACATTTCCAGGCCGAGATGGAGTGCTTAGAGTGGTCGACATAAGGACGGCCGCAGGGACACAGCAAGTCAAATACCGCATTCCCGCTGTAAAAGCGGTGATGTACCGTGCGCCGTGCGGCCGCCGCATCAGGGACTACAAGGAGCTCCACCAATACCTGCAAGCCATAGACAGCGACATGGGCGTGGACCTGTTCGACTTTAACCCGGCCACGCACTGTCTGGCGGAGTTCCTGCTGAACAAGTGTCTTATTAGCAAGAAGGTCAGTGTCTAA
Protein Sequence: MTIKPHKMASHTCGPRCKRTDVLALKDLRTYNPLTKPLLSGWESLSADAAIMCLCRFIAKRGTPSQIYSDNGLPTSVQTDSYAHFMMKPSLIMPLTKKLNGFSFPPPHLTWDEVLTTLLAEAEALVNARPLTHVSPDAADPEALTPCHLLLGSSSGRPIPAQLTDSDLCSRSGWRRALRLADHFWRRWVIEYLPTLAPRRVRGLPTPTISIGDPVLIADGDLPRGTWPRGVVSRTFPGRDGVLRVVDIRTAAGTQQVKYRIPAVKAVMYRAPCGRRIRDYKELHQYLQAIDSDMGVDLFDFNPATHCLAEFLLNKCLISKKVSV

Sequence clustering based on sequence similarity using MMseqs2