Ebru015305.1
Basic Information
- Insect
- Epinotia brunnichana
- Gene Symbol
- Poxn
- Assembly
- GCA_963854355.1
- Location
- OY977937.1:42850585-42856717[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 6 5.1e-43 2.4e-39 136.1 0.4 1 78 7 84 7 94 0.96 2 6 7.3e-18 3.4e-14 54.8 0.1 39 80 126 167 105 177 0.81 3 6 1.5e-21 7.1e-18 66.7 0.0 33 80 201 248 185 259 0.86 4 6 1.6e-21 7.3e-18 66.7 0.1 33 80 282 329 263 339 0.85 5 6 2.3e-20 1.1e-16 62.9 0.0 35 80 365 410 349 423 0.86 6 6 5e-21 2.3e-17 65.1 0.1 35 77 446 488 431 497 0.92
Sequence Information
- Coding Sequence
- ATGCGCGGAGTTCCTCAAGGGCAAGCTGGCGTGAACCAACTGGGCGGCGTGTTCGTGAACGGACGGCCGCTGCCCGACGTGGTGCGCAAGCGCATCGTGGAGCTCGCTATCATGGGCGTGCGCCCATGCGACATCAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCACACGCTTCTACGAGACGGGCAGCATCCGCCCTGGCTCCATCGGCGGCAGCAAGACCAAGGTGAGCTCCAGAATGTTCTGGCGCCGTGCGACATCAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCGCTCGCTTCTACGAGACGGGCAGCATCCGCCCTGGCTCCATCGGCGGCAGCAAGACCAAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCACACGCTTCTACGAGACGGGCAGCATCCGCCCCGGCTCCATCGGCGGCAGCAAGACCAAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCACACGCTTCTACGAGACGGGCAGCATCCGCCCTGGCTCCATCGGCGGCAGCAAGACCAAGGTGAGCTCCAGAATGTTCTGGCGCCGTGCGACATCAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCACACGCTTCTACGAGACGGGCAGCATCCGCCCTGGCTCCATCGGCGGCAGCAAGACCAAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCGCTCGCTTCTACGAGACGGGCAGCATCCGCCCCGGCTCCATCGGCGGCAGCAAGACCAAGGTGAGCTCCAGAATGTTCTGGCGCCGTGCGACATCAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCACACGCTTCTACGAGACGGGCAGCATCCGCCCTGGCTCCATCGGCGGCAGCAAGACCAAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCACACGCTTCTACGAGACGGGCAGCATCCGCCCTGGCTCCATCGGCGGCAGCAAGACCAAGGTGAGCTCCAGAATGTTCTGGCGCTGTGCGACATCAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCGCTCGCTTCTACGAGACGGGCAGCATCCGCCCCGGCTCCATCGGCGGCAGCAAGACCAAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCGCTCGCTTCAACGACACGGGCAGCATCCGCCCTGGCTCCATCGGCGGCAGCAAGACCAAGGTGAGCTCCAGAATGTTCTGGCGCTGTGCGACATCAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCGCTCGCTTCTACGAGACGGGCAGCATCCGCCCCGGCTCCATCGGCGGCAGCAAGACCAAGGTGAGCTCCAGAATGTTCTGGCGCTGTGCGACATCAGCCGCCAGCTGCTCGTGTCACACGGCTGCGTATCCAAGATCCTCGCTCGCTTCTACGAGACGGGCAGCATCCGCCCTGGCTCCATCGGCGACAGCAAGACCAAGGTGA
- Protein Sequence
- MRGVPQGQAGVNQLGGVFVNGRPLPDVVRKRIVELAIMGVRPCDISRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKVSSRMFWRRATSAASCSCHTAAYPRSSLASTRRAASALAPSAAARPSRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKPPAARVTRLRIQDPHTLLRDGQHPPWLHRRQQDQGELQNVLAPCDISRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKPPAARVTRLRIQDPRSLLRDGQHPPRLHRRQQDQGELQNVLAPCDISRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKPPAARVTRLRIQDPHTLLRDGQHPPWLHRRQQDQGELQNVLALCDISRQLLVSHGCVSKILARFYETGSIRPGSIGGSKTKPPAARVTRLRIQDPRSLQRHGQHPPWLHRRQQDQGELQNVLALCDISRQLLVSHGCVSKILARFYETGSIRPGSIGGSKTKVSSRMFWRCATSAASCSCHTAAYPRSSLASTRRAASALAPSATARPR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -