Basic Information

Gene Symbol
zfy1
Assembly
GCA_947049265.1
Location
CAMRIQ010000200.1:397507-400236[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.00049 0.039 15.5 3.7 1 23 13 35 13 36 0.96
2 9 0.074 6 8.6 0.1 6 23 50 67 49 67 0.98
3 9 0.00085 0.069 14.7 1.3 1 23 72 95 72 95 0.95
4 9 0.0029 0.23 13.1 0.1 2 23 111 131 110 131 0.96
5 9 5.5e-05 0.0044 18.5 0.5 1 20 137 156 137 159 0.92
6 9 0.0002 0.016 16.7 0.8 1 23 167 189 167 189 0.98
7 9 0.0045 0.36 12.5 6.4 1 23 195 217 195 217 0.98
8 9 1.4e-06 0.00012 23.5 1.4 1 23 223 247 223 247 0.98
9 9 0.023 1.9 10.2 2.1 1 23 253 275 253 276 0.95

Sequence Information

Coding Sequence
ATGGATCACCACAACACGCACACGGGCCGCGCGCCCTACAAGTGCACCGTCTGCGACGACACCTTCCGCAGATACTCCAACATGGTGCAGCACAGGGACCGGCACCACCTGCACAAGAAGCGCGTGGTGCGCGACCTGGtgtgcgcgtgcggcgcggtGTTCCACTCGCGCGCCAAGCTGCGCTGGCACGCGGAGACGCACGCGGCGCGCCCGCACGCGTGCCTGACGTGCGGCGACAAGTTCGTGCACGCGGCCAGCCTCACGCGGCACGTGCGGCGCGCGCACGACCCCGCCTACACCgacgcgcggcgcccgcgccagCCCAACGTGCCCTGTCCCGTCTGCAAGCAGTTGTACCTGCGGTCGAACCTGCGCGCGCACATGCTGACGCACAGCGGCAAGCGGCCGTTCGTGTGCGTGGTGTGCAGCAAGGCCTTCACCACCAAGTGGAACCTCAAGCTGCACCGCTGGACGCACGCGTCGCGCTCCGCGAAGCCCTACAAGTGCACGCTGTGCAAGGGCGCCTTCATCCGCCACTCCGAGTACGTCGCGCACATGAACGCGCACAAGGCCGTGCGCCCGTACACCTGCAACTACTGCGGCTGCCAGTTCATCCGCAAGTACAACTGCCAGCTCCACGTGCGCGAGCACGAGACCGCCAAGAAGTACGTGTGCAAGGTGGCCGAGTGCGGCAAGTCCTTCCACCGCTCCTACTACCTGTCCGAGCACATGAAGGTGCACAGCGGCGCGAGGCCCTTCGCGTGCGGCGTCTGCGGCAAGCTGTCCGGCAACAAGTCCAACCATAACAAGCACGTGCGCATCCACCACGCGCGCGAGCCCGTCGCCAGCGAGGCCTAG
Protein Sequence
MDHHNTHTGRAPYKCTVCDDTFRRYSNMVQHRDRHHLHKKRVVRDLVCACGAVFHSRAKLRWHAETHAARPHACLTCGDKFVHAASLTRHVRRAHDPAYTDARRPRQPNVPCPVCKQLYLRSNLRAHMLTHSGKRPFVCVVCSKAFTTKWNLKLHRWTHASRSAKPYKCTLCKGAFIRHSEYVAHMNAHKAVRPYTCNYCGCQFIRKYNCQLHVREHETAKKYVCKVAECGKSFHRSYYLSEHMKVHSGARPFACGVCGKLSGNKSNHNKHVRIHHAREPVASEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00148826;
90% Identity
iTF_00658805;
80% Identity
-