Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00023 0.91 9.8 0.1 17 48 41 72 34 78 0.85

2 6 0.0004 1.5 9.1 0.1 23 45 75 97 71 101 0.89

3 6 0.0045 17 5.7 0.3 20 43 100 123 96 130 0.87

4 6 0.038 1.5e+02 2.7 0.1 21 44 129 152 126 160 0.86

5 6 0.0013 5.1 7.4 0.0 23 45 159 181 156 186 0.91

6 6 2.7 1e+04 -3.2 0.0 22 33 212 225 210 229 0.65

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00023	0.91	9.8	0.1	17	48	41	72	34	78	0.85
2	6	0.0004	1.5	9.1	0.1	23	45	75	97	71	101	0.89
3	6	0.0045	17	5.7	0.3	20	43	100	123	96	130	0.87
4	6	0.038	1.5e+02	2.7	0.1	21	44	129	152	126	160	0.86
5	6	0.0013	5.1	7.4	0.0	23	45	159	181	156	186	0.91
6	6	2.7	1e+04	-3.2	0.0	22	33	212	225	210	229	0.65

Coding Sequence: ATGGCCTCTAGAGAGGAGTTTGAAGATATGCCAGTCAATGTTGCGATGGCAATGTACACTTGCAAAAGATGTAATAAGATATTTCCTTgtaagcgcgaccaattgctgcacaaaaaggaagtgcattcccaaacaaaatcatcttatgagtgcaaaatatgtaataagtatttttgtaatagcggtaatttggaacgtcatatgaaggtgcataatgatgtgagaccatttatttgtcgcatctgtggcaaagccttcgcccaatctgtaaacttaaatcgtcactattctgtgcacaatggcgaacgtccttatccatgtacattttgttcgaaaacatttacccagcagtccaacatgcaacgccaccagctcacacatacaggagagaagccatttcgttgcaaacgttgtggtcgctacttttcgcaacgggttaaccttaaaaagcatataatgggtcacttgaacaccaaaccatacacgtgtaaaatatgtcaaaagtcattcatacaattgggtaatttcaaaaaacatctgcaatcgcatgttaaggaaggcatggaggttgatatgAAAGCCTTAGTGGCCGAAGCCCAAGCAATGGCTAAACAAAGTCTGGAAATGGCCGATGAACAACCTGTTGGCTTCGAATGTGCCGTTTGCCGTTCGATCTTTAATAACTTCACCGATTTTGAAATGCATGAAAGTGAGTGCAATGATAATGCACAGGCGGCCTTGGAACAAAAATACAATCCGGATCAACAACTTCACGAAGTTGTTGTGGAAGAGGTCGAGGACCATATCGAAGAACATATTATTCCACATGAAGGTGGCAGCAGTGTTGAACATTTTGGCAGTTATGCACCATTAAAATTTAGTGTCTCGCAATTGGATACGCATGAAATTATAATCGAGACCAGCCGATAA
Protein Sequence: MASREEFEDMPVNVAMAMYTCKRCNKIFPCKRDQLLHKKEVHSQTKSSYECKICNKYFCNSGNLERHMKVHNDVRPFICRICGKAFAQSVNLNRHYSVHNGERPYPCTFCSKTFTQQSNMQRHQLTHTGEKPFRCKRCGRYFSQRVNLKKHIMGHLNTKPYTCKICQKSFIQLGNFKKHLQSHVKEGMEVDMKALVAEAQAMAKQSLEMADEQPVGFECAVCRSIFNNFTDFEMHESECNDNAQAALEQKYNPDQQLHEVVVEEVEDHIEEHIIPHEGGSSVEHFGSYAPLKFSVSQLDTHEIIIETSR

Sequence clustering based on sequence similarity using MMseqs2