Basic Information

Gene Symbol
-
Assembly
GCA_932527255.1
Location
CAKOBP010000010.1:6582765-6587279[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 6.8 4.4e+02 1.8 1.8 1 23 319 349 319 349 0.75
2 13 0.0012 0.079 13.6 0.5 1 23 355 378 355 378 0.95
3 13 1.5e-05 0.00097 19.6 0.8 1 23 383 406 383 406 0.96
4 13 2.1e-05 0.0013 19.1 4.5 1 23 411 433 411 433 0.97
5 13 0.058 3.8 8.3 5.2 2 23 440 461 439 461 0.95
6 13 0.0013 0.083 13.5 2.8 2 23 469 491 469 491 0.95
7 13 0.013 0.83 10.4 1.2 1 23 497 520 497 520 0.95
8 13 0.0035 0.23 12.1 0.9 2 23 531 553 530 553 0.93
9 13 2.2e-07 1.4e-05 25.4 0.7 1 23 581 603 581 603 0.98
10 13 5.7e-06 0.00037 20.9 2.3 1 23 610 632 610 632 0.96
11 13 0.00014 0.0092 16.5 0.2 2 23 639 660 639 660 0.97
12 13 0.0093 0.61 10.8 1.2 1 23 667 689 667 689 0.98
13 13 0.00026 0.017 15.7 3.3 1 23 695 718 695 718 0.98

Sequence Information

Coding Sequence
atGGAAACTTGTCGTACTTGTGCCAAATGTGATTTTGATAATGAAAGCCAATGGCTGGATTTATTTAATGCCCCTCGTTGGCAACTTGAAACTCAGCGTATACATTTGGAGTTAAGCACTTGGAAAATTAAGATATCATGCAGCGATGGTTTGCCGCAAAAAATTTGTACTGATTGTTTTTCCAAATTTTGCACGGTATCGTCATTTCGTTTGCAATGTTTGGAGGCACAAACGATTTTAAGCAATATATTCGATAAAATCGATACACAAAGTATACACGAAGGTGAAGAAGACGAACAAATGTTCGAGGGTTCTGCTAATGAGCAGGATAATAGTGGACAAAAAACCGTAACAACTGCAACACACTCGACGGCAGCAGCTGAGGAAGCAGCGACATCAGCAGCAATAACAGTACACTTTAAGTCAAATGCACACACATTCGAAACAGCAACAGAAAAGAGCACAACTAACGATAACAGTAGCAACAATAACAACAACTATAGAAATAATAATAACAATGAAAATTTAAATTTTAGCGAAATTTTAAATTTTAATCCTGACAACAACACCGAGGTTTCATTTGAAAACGTTACAAAATTATCAGACACTGCCCGTTTAAAAAACGAAACTAAAAACCAACATTTTAATAACATTTTCGAACAAGTAGAAGAAGATATAAACAACAACACCAACAATATTAATAGTAATGTTGAAGAAGACACCAGGAACACACCTACTTTTAATAATAATGAAGAACTACGAGATGATACCAACGATTTAGATGAAAATGATCTTATTGAAGAACTTATCGAGGAACTCGATATCATTGAAGAAATCGCTGAAGAACAGGAAAATGAGTATTTCAGTGACGAAAATCAAACCATTGGAAACATTATTTTGTCCCAAGTCACTGACAACGAAGACGAACTTTTCGCCGATAACTTAAAAATAACTTTCGAATGCAAATATTGCTACAAATGGAAGAATAGTAATTCGGAAATTTTTCAAACCCAACAAGAGCTGTTGGCTCACATAACCGGACTACATAGTTCAGAGCAACCGTATAATTGCCCCTATTGCAAGCAAACGTTTATGGATGCAGCTTCTAGAACCACACATTTGAAGGAGGACCACAGCCAAAAGGTGTATGATTGCGCAACCTGTGGTAAAAAGTATGCCGATAAATTTAATTTAAGAAATCACATTGAAAAGTATCACAGTGGCACCGATTTCGACTGCACACTGTGCGATAAGAGTTTTTGTTCGAGGAAAAGTTTAAATTATCACATGAAATGGCATAATCCCAAAGAGCAATTGAAATGTAGCTATTGTGACCGTTTGTTTATCAATCAGAGACACTTGAAGTGTCACGAAGAAACTCACACGGGATTTCGTAGTCAAGAGGTTTGCTCGTTTTGTGGAAAAAATTTTTTCCATTTGAAAACTCTTAGATGGCATATTTATCGCCAGCACGGGGGCGAAAAACCATACAAATGTGCTAGATGTACAGAAGTCTTTACGTCTTACTTCGAAAAACGCATCCACATGCTTGAATATCATTTGGACAATTTGACGCAAATCGAAAAAACTGAATGTATGCTCTGCCACAAACGTTACGAAAACGAACAGGAACTTAAGGATCACATGTTAGATGATCACAAGGAAAATAAGGGGGCTGTCAAAATAGCGAATAACAAAAGAGTTATTATGAATAAAAAGCCAAAAAGTTTTACGGGAATATTTCAATGTGAAAAATGTGATAAGAGATTTAATATGAAGTCTGCCTTGGAAAGACACATGGCGGTACATTCTACGGAGGGAAGGCCTCATGCCTGTCCACAATGTCCCAAGCGTTTCAAGCGCTCTCAAGACATGAAATGGCATTTAAAAACACATTCTTCAGAGAAACCAAATGTCTGTGATGTTTGTGGCAAAGGATTTGCTTTAAAATATGTATTAACTCAACATCGCAGAAGCCACGAAGTTTTAGAAAAGAACTTCACATGCTCCACCTGTGGTAGGTCATATCTTTTTGAGAAGTCTTTGCGCTTGCACGAGCGCATACACAGTGGTAAAACCTTCTATAAATGTGATTTATGCAGTGAAAGTTTTGTTACACACATTAAATTCAAATGGCATATGAAAAAAATGCATGACGAAGAGGAGGTGGCTGCTACAAACTTTAATCTTTATAAAAACAAAACTAACGTTGAGCTGCCATTGGACGATTTGGCCAACATTGTGATAACCTAA
Protein Sequence
METCRTCAKCDFDNESQWLDLFNAPRWQLETQRIHLELSTWKIKISCSDGLPQKICTDCFSKFCTVSSFRLQCLEAQTILSNIFDKIDTQSIHEGEEDEQMFEGSANEQDNSGQKTVTTATHSTAAAEEAATSAAITVHFKSNAHTFETATEKSTTNDNSSNNNNNYRNNNNNENLNFSEILNFNPDNNTEVSFENVTKLSDTARLKNETKNQHFNNIFEQVEEDINNNTNNINSNVEEDTRNTPTFNNNEELRDDTNDLDENDLIEELIEELDIIEEIAEEQENEYFSDENQTIGNIILSQVTDNEDELFADNLKITFECKYCYKWKNSNSEIFQTQQELLAHITGLHSSEQPYNCPYCKQTFMDAASRTTHLKEDHSQKVYDCATCGKKYADKFNLRNHIEKYHSGTDFDCTLCDKSFCSRKSLNYHMKWHNPKEQLKCSYCDRLFINQRHLKCHEETHTGFRSQEVCSFCGKNFFHLKTLRWHIYRQHGGEKPYKCARCTEVFTSYFEKRIHMLEYHLDNLTQIEKTECMLCHKRYENEQELKDHMLDDHKENKGAVKIANNKRVIMNKKPKSFTGIFQCEKCDKRFNMKSALERHMAVHSTEGRPHACPQCPKRFKRSQDMKWHLKTHSSEKPNVCDVCGKGFALKYVLTQHRRSHEVLEKNFTCSTCGRSYLFEKSLRLHERIHSGKTFYKCDLCSESFVTHIKFKWHMKKMHDEEEVAATNFNLYKNKTNVELPLDDLANIVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00435833;
90% Identity
-
80% Identity
-