Esuc016547.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Epicampocera succincta
Gene Symbol
MBD-R2
Assembly
GCA_932527255.1
Location
CAKOBP010000089.1:3181977-3186522[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.7e-22 6.7e-19 67.4 0.1 4 76 421 491 418 492 0.93
2 2 1.8 7e+03 -3.2 0.0 45 63 925 941 924 946 0.79

Sequence Information

Coding Sequence
ATGGGACGCCGGTGTTGTATAGGCGGTTGCACGTCAACTTCACGCTTGCCAGAACATCACGGTGTTACTTACCATTCGTTTCCCGCTGATCAAAATTCGCGCTCTATTTGGATACGAAATACCAAAATAAGTGTAGACCGTCATATTACTAAAAGCGTTTTAGTATGCTCTAGACACTTTCGTCGTGCTGACTTTCAGCCACAACGTAGCGGCAAATATTTGCTAAAACAGAAAGTTTTTCCCACTGTGTTTCCGTGGGGCAAAATCGACGCTGCTCAAATTGAAGAAGACTTAGAATTTTTAAATTCTACCAGTGTGGCACCACCTAGTAATTTGTTGACCACTTCTTCGGCCGTTGATGAAGACACAAAGGCTACTGTTGCGGCCACAGTAGCACAAATAATGGCACAAACAGCGGAATTAAATGCTGCTGCTGGCATAAAAGTAGAAAAGCTTGATGGTAGCTTAGAAGAACCTTTAAATGATAGTGCCAGTGCGAGTACGTCTGTACAGCCAAATGTTAAATTTGAGCCTGTTACTTCCTTCAATCCCGGAGCACGTTTGGAAGCTCAAGACTTTGATGGTGTCTGGCATGCAGCACGTATTGTGGAAGTTGATAACGATGATCGTGAAGTTCTAATTAAATTTGAAAAAAATGCCAAACATAAATCCAATGTTGCTGGTACTGAAGAATGGATTCCTATGAATTCGTCCCGTTTGCGACAACGTATCTCCACCAAACCGATTTTAAATTTCGAACTGGAAGAGAAATGTTTAGCCCGTTGGTCGGGGCCTCGCAAATTTCCCGGCACAGTTAAGAAAATTTTGCCAAATGATGTCTATGAAATTTTGTTTGATGATGGTTATGTCAAAAATGTGCGCGCTATTCATATGAATAAAGTTCAGACAACTGCGGCCGTCAAAACGGAGGTTGTAGACAGAGCAACAGTAAACACATCACCAATTTTGGCCGTTGCTCCGGCAAATAACGATTCAAGTTTAGCTACGCTACCTGTAACACCTTCAAGTTCTGCTGTGAAAAGGCCATCTTCTGGCCAGAATTCTGGGTCTCAACTGAAAAAAAGAGCTCCCAATGGACCGCGAAAGGATTGGCCACTTTTGGATTTATCTAAATTGGATTTCTCTTCCCTTAATTTACCTGAAATTCCTAAAGATGGCGAATGGACTTGTCATTGGGTAAATGATCAGCCTATAGGACGTGAAGGCTATTTGGTTGTGGGAGAACATCGTAAGCCTACTGTTATTGTAGAAGATTGGCGTCTGCCCCCTGGCTGGATCAAGCACATGTATCAGCGTTCTAATGTTTTAGGAAAATGGGATGTGATTCTAGTAACACCGAATGGTAAACGTTTTAGATCTAAAGCTGATCTTAAAACGTATTTGGAGGAGCTGGGACAAGTTTACAATCCTGACATTTACGACTTTAGCATACATCGTCGTAGAGCCAAAGATATCAACTGTTACGTTCATACACCTGACTATGTACCACAACAGCCGGTTAAATCAAAAACTTCCCTAAACACATCATTGGATAGCAGTTTGGAAAACAAGACTTCATCGTTGGTAGAAGCATTGCCGTCAGCTGTCTCCTCGCCCTACATGGATACTCCTATTGCAGAGGCTTTGCCACCTATAGAATTATTAACTTCTTCCAGTAGTTTGGCGGCAGAGGATAAGAGCGTGACCCAAGTAGAGGCTGAAGTACCAAAGCAACTGCTTGAAGCGGCAGAAATTAGTTCTACACCAACTCCCACTTCAACACCTACAGTCGGTCTAAAGGAAGAAGTTGTAGTATCTTCAGATAGTGGAACGCCTACACCCTCAACGACACCAGCAAATAATTTAGAAGAAGCCCAACAAGCTGAGGGGGGTTATGCTTTAATTGGTGGCTTAAAGGTCCAAATCATCGATAATCTATTTCGCTGTCCCCAGGAGGGATGCTCCAAAAACTTCAGGAAGGAAAACCATTTACAAATTCACGTAAAACATTATCATCGAAACTTGGTCAAACTATTAGGGTCCTGTCCCAAAATGTTGGAACTGGCGGAAAAACGCACACATCCTGTTGATAACGAAGCAAATGAACCGGTGCCCAAAAATCAAATTCCCAATCAACAATTCTTTGCCAAATTACACCAACAAGACCTGGAACAAACTAGGGCTCATCGTAGGAGTACTGGACTGCATAAAGGCACTGCTGATACACCTCCGGCAGAGGTAAAAACAGAAGAGACTGACGAAGCCGCTGCTAAAGTTGAGGAAAGCACACAAAATATGGAAAATTCACAAAACGATGCTTCCTTAAATAACACAACTGCTACTTCGAGTGTTCTACTGGAGAATTCGTTTGCCTCCAACAGCGCCGCAGATGACTCGTTAGCAACTGAAGGGGGTTTGACAGAACCTCCAGCCACTAAAAGGTCCAGATTTTCTGTAAACAAGAAAGCATTTGGTTCAAGAAAAAGTAATCGCCAAAGAACTACTAGGAAATATCTGACCGCAGCTCAGGCCACAGCTGGGGTGGTGGCCTCTTCAACCTCCCTACCGGTTGCCGGCGATACAAGCTTCAGTAGTGTGACTGAATTTGAGGAGACGCGCCATTCATTCAATGGTACACCAGACATTAACAAAGATATAAAAAAACGTAAAACTGCTTTATCCTCCAATACTCCTCTCAGCAGCGTTGATTCTCCCATTACAGCCGACTCGGGCTCAAATTCTTTCCAACCACAAAACTCCACAGAAAACGATACGATTAATCAACCTCCCCAATATATCAAAGAAAATGGTGAACTCATTAAAATCGTGCACATGCGTCAGGAGGAAATTATTAATTGCTTGTGCGGCTACTGTGAAGAAGATGGTTTAATGATACAATGTGAGCTTTGTCTCTGCTGGCAGCATGGCCTGTGTAATGGCATCGACAAAGTTTCTCAAGTACCAGACAAGTATGTTTGTTTTATTTGTCGCAATCCCCAGAGAGTACGTGAATCGTTACGTTTTAAACATGATCAGGATTGGTTGTATGAGGGCAAGTTACCCGTGGCCAACTACCACACTTCTAATCCCAGCCAGTTGAATAAAAGATCAGAATACCTCAAAAGGTCTCATATTTTAACTGGCAATCTTTTAGAGTTAAAGAACTACATGCATTCGTTGAGGGTTAAAATCAATATAGCCAACAATAAATGTCACCCCAAGCTCTATCTCTGGGCAAAGAAATGGGATGAGGACATAATCGCTGATGGCAATTTAGCTGTTACGCCTACAAAGAAAATTAAATCCGAACCTACAACACCGGCGAGACTTGTACCAAATATTCCACAACCCGAAGCTCCCATTGACCCCGTGGAATGTCAACAGCGCTTAATGGAACACATTAAAATTCAACAAGATCTGGTCATGGGCCGCTTAGATGATATTGAAGCAGTCATAAATGTTTTGGAAAGCGAAGATGATTTGCCGGACTTGCGTGAAGAAGATTTCGGCAGCACCAAGGATGCTTTAGCTGCCTTTATTAAAGAATTGGATACAGTGAAAAAAATTGCCAAACTCAACAGTTTGGAACATACTAAATTGGCCCATAAAAATCCCACTCCTCCCGTTAAATAG
Protein Sequence
MGRRCCIGGCTSTSRLPEHHGVTYHSFPADQNSRSIWIRNTKISVDRHITKSVLVCSRHFRRADFQPQRSGKYLLKQKVFPTVFPWGKIDAAQIEEDLEFLNSTSVAPPSNLLTTSSAVDEDTKATVAATVAQIMAQTAELNAAAGIKVEKLDGSLEEPLNDSASASTSVQPNVKFEPVTSFNPGARLEAQDFDGVWHAARIVEVDNDDREVLIKFEKNAKHKSNVAGTEEWIPMNSSRLRQRISTKPILNFELEEKCLARWSGPRKFPGTVKKILPNDVYEILFDDGYVKNVRAIHMNKVQTTAAVKTEVVDRATVNTSPILAVAPANNDSSLATLPVTPSSSAVKRPSSGQNSGSQLKKRAPNGPRKDWPLLDLSKLDFSSLNLPEIPKDGEWTCHWVNDQPIGREGYLVVGEHRKPTVIVEDWRLPPGWIKHMYQRSNVLGKWDVILVTPNGKRFRSKADLKTYLEELGQVYNPDIYDFSIHRRRAKDINCYVHTPDYVPQQPVKSKTSLNTSLDSSLENKTSSLVEALPSAVSSPYMDTPIAEALPPIELLTSSSSLAAEDKSVTQVEAEVPKQLLEAAEISSTPTPTSTPTVGLKEEVVVSSDSGTPTPSTTPANNLEEAQQAEGGYALIGGLKVQIIDNLFRCPQEGCSKNFRKENHLQIHVKHYHRNLVKLLGSCPKMLELAEKRTHPVDNEANEPVPKNQIPNQQFFAKLHQQDLEQTRAHRRSTGLHKGTADTPPAEVKTEETDEAAAKVEESTQNMENSQNDASLNNTTATSSVLLENSFASNSAADDSLATEGGLTEPPATKRSRFSVNKKAFGSRKSNRQRTTRKYLTAAQATAGVVASSTSLPVAGDTSFSSVTEFEETRHSFNGTPDINKDIKKRKTALSSNTPLSSVDSPITADSGSNSFQPQNSTENDTINQPPQYIKENGELIKIVHMRQEEIINCLCGYCEEDGLMIQCELCLCWQHGLCNGIDKVSQVPDKYVCFICRNPQRVRESLRFKHDQDWLYEGKLPVANYHTSNPSQLNKRSEYLKRSHILTGNLLELKNYMHSLRVKINIANNKCHPKLYLWAKKWDEDIIADGNLAVTPTKKIKSEPTTPARLVPNIPQPEAPIDPVECQQRLMEHIKIQQDLVMGRLDDIEAVINVLESEDDLPDLREEDFGSTKDALAAFIKELDTVKKIAKLNSLEHTKLAHKNPTPPVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01174299;
90% Identity
iTF_00655357;
80% Identity
iTF_00655357;