Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.1e-07 0.0009 20.0 0.0 29 50 9 30 6 32 0.91

2 2 3.3e-11 1.4e-07 32.2 0.0 7 70 37 98 35 103 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.1e-07	0.0009	20.0	0.0	29	50	9	30	6	32	0.91
2	2	3.3e-11	1.4e-07	32.2	0.0	7	70	37	98	35	103	0.87

Coding Sequence: ATGTACGGTGTGGTGTGGTATGAGCGCAAGGCCGACATATACTACTTAACGCCGCAGGGCAAGAAGCTACGCTCCACTAGGGAGGTGAGTGAGATGTCGTTTCCGCTGCTCCGTGTGCCACTGGAGAGGGGCTGGAAACGCGAGTTGGTGTACCGCGCCGCACTCGACCAGCACTCGCGGCGTAACGCGGACATATACTGCTACACGTCGCAAGGCAAGAAGCTACGCTCCACTATGGAGGTAGCGGAACACCTATCTGGAACCGGATTGTCAATTGAAAACTTTTCGTTCTTCAAAGAACCGTTGGGTGTTGATGACCCTGAAAGAGAAATCATTCGTGACGCGAAGTTGATGCGGCGCGTGGAGTCCCCGGTGGCCCAGACGGCGCCCGCGACTGAGGGCAAGCGCACGCCGAAGCCCAAGCCCCCGAAGGGAGCCAGCCCCGAGCCACAGAGGCCCAAATCTCCGCCCGTCAAGATCAAGGTGAAGTCAATGCCGCCCCGGCTAAACCGCATGCCGGCCGCGACGCCGCCCGCCAAGAAGCCGGCGCAGGACAACAACAACTCGCAAGCCTTCAAGAAGAACAGGTATTTAGGAGCTAAGCACGTAGGCTAcggttaa
Protein Sequence: MYGVVWYERKADIYYLTPQGKKLRSTREVSEMSFPLLRVPLERGWKRELVYRAALDQHSRRNADIYCYTSQGKKLRSTMEVAEHLSGTGLSIENFSFFKEPLGVDDPEREIIRDAKLMRRVESPVAQTAPATEGKRTPKPKPPKGASPEPQRPKSPPVKIKVKSMPPRLNRMPAATPPAKKPAQDNNNSQAFKKNRYLGAKHVGYG

Sequence clustering based on sequence similarity using MMseqs2